Journal article
Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening.
Abstract
Hematopoietic stem and progenitor cell differentiation are blocked in acute myeloid leukemia (AML) resulting in cytopenias and a high risk of death. Most patients with AML become resistant to treatment due to lack of effective cytotoxic and differentiation promoting compounds. High MN1 expression confers poor prognosis to AML patients and induces resistance to cytarabine and alltrans-retinoic acid (ATRA) induced differentiation. Using a …
Authors
Sharma A; Jyotsana N; Lai CK; Chaturvedi A; Gabdoulline R; Görlich K; Murphy C; Blanchard JE; Ganser A; Brown E
Journal
Current Cancer Drug Targets, Vol. 16, No. 9, pp. 818–828
Publisher
Bentham Science Publishers
Publication Date
2016
DOI
10.2174/1568009616666160617103301
ISSN
1568-0096