Infections in pediatric acute promyelocytic leukemia: from the canadian infections in acute myeloid leukemia research group Academic Article uri icon

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abstract

  • BACKGROUND: It is not known whether children with acute promyelocytic leukemia (APL) have an infection risk similar to non- APL acute myeloid leukemia. The objective was to describe infectious risk in children with newly diagnosed APL and to describe factors associated with these infections. METHODS: We conducted a retrospective, population-based cohort study that included children ≤ 18 years of age with de novo APL treated at 15 Canadian centers. Thirty-three children with APL were included; 78.8% were treated with APL -specific protocols. RESULTS: Bacterial sterile site infection occurred in 12 (36.4%) and fungal sterile site infection occurred in 2 (6.1%) children. Of the 127 chemotherapy courses, 101 (79.5%) were classified as intensive and among these, the proportion in which a sterile site microbiologically documented infection occurred was 14/101 (13.9%). There was one infection-related death. CONCLUSIONS: One third of children with APL experienced at least one sterile site bacterial infection throughout treatment and 14% of intensive chemotherapy courses were associated with a microbiologically documented sterile site infection. Infection rates in pediatric APL may be lower compared to non- APL acute myeloid leukemia although these children may still benefit from aggressive supportive care during intensive chemotherapy.

authors

  • Cellot, Sonia
  • Johnston, Donna
  • Dix, David
  • Ethier, Marie-Chantal
  • Gillmeister, Biljana
  • Mitchell, David
  • Yanofsky, Rochelle
  • Lewis, Victor
  • Portwine, Carol
  • Price, Victoria
  • Zelcer, Shayna
  • Silva, Mariana
  • Bowes, Lynette
  • Michon, Bruno
  • Stobart, Kent
  • Brossard, Josee
  • Beyene, Joseph
  • Sung, Lillian

publication date

  • December 2013