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Diminished AHR Signaling Drives Human Acute...
Journal article

Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance

Abstract

Eliminating leukemic stem cells (LSC) is a sought after therapeutic paradigm for the treatment of acute myeloid leukemia (AML). While repression of aryl hydrocarbon receptor (AHR) signaling has been shown to promote short-term maintenance of primitive AML cells in culture, no work to date has examined whether altered AHR signaling plays a pathologic role in human AML or whether it contributes at all to endogenous LSC function. Here, we show AHR …

Authors

Ly M; Rentas S; Vujovic A; Wong N; Moreira S; Xu J; Holzapfel N; Bhatia S; Tran D; Minden MD

Journal

Cancer Research, Vol. 79, No. 22, pp. 5799–5811

Publisher

American Association for Cancer Research (AACR)

Publication Date

November 15, 2019

DOI

10.1158/0008-5472.can-19-0274

ISSN

0008-5472