Journal article
Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance
Abstract
Eliminating leukemic stem cells (LSC) is a sought after therapeutic paradigm for the treatment of acute myeloid leukemia (AML). While repression of aryl hydrocarbon receptor (AHR) signaling has been shown to promote short-term maintenance of primitive AML cells in culture, no work to date has examined whether altered AHR signaling plays a pathologic role in human AML or whether it contributes at all to endogenous LSC function. Here, we show AHR …
Authors
Ly M; Rentas S; Vujovic A; Wong N; Moreira S; Xu J; Holzapfel N; Bhatia S; Tran D; Minden MD
Journal
Cancer Research, Vol. 79, No. 22, pp. 5799–5811
Publisher
American Association for Cancer Research (AACR)
Publication Date
November 15, 2019
DOI
10.1158/0008-5472.can-19-0274
ISSN
0008-5472