Journal article
Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells
Abstract
Selective targeting of cancer stem cells (CSCs) offers promise for a new generation of therapeutics. However, assays for both human CSCs and normal stem cells that are amenable to robust biological screens are limited. Using a discovery platform that reveals differences between neoplastic and normal human pluripotent stem cells (hPSC), we identify small molecules from libraries of known compounds that induce differentiation to overcome …
Authors
Sachlos E; Risueño RM; Laronde S; Shapovalova Z; Lee J-H; Russell J; Malig M; McNicol JD; Fiebig-Comyn A; Graham M
Journal
Cell, Vol. 149, No. 6, pp. 1284–1297
Publisher
Elsevier
Publication Date
June 2012
DOI
10.1016/j.cell.2012.03.049
ISSN
0092-8674