Journal article
Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex
Abstract
Pathways defining susceptibility of normal cells to oncogenic transformation may be valuable therapeutic targets. We characterized the cell of origin and its critical pathways in MN1-induced leukemias. Common myeloid (CMP) but not granulocyte-macrophage progenitors (GMP) could be transformed by MN1. Complementation studies of CMP-signature genes in GMPs demonstrated that MN1-leukemogenicity required the MEIS1/AbdB-like HOX-protein complex. …
Authors
Heuser M; Yun H; Berg T; Yung E; Argiropoulos B; Kuchenbauer F; Park G; Hamwi I; Palmqvist L; Lai CK
Journal
Cancer Cell, Vol. 20, No. 1, pp. 39–52
Publisher
Elsevier
Publication Date
July 2011
DOI
10.1016/j.ccr.2011.06.020
ISSN
1535-6108
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCell Transformation, NeoplasticGene Expression ProfilingGene Expression Regulation, LeukemicGenes, DominantGranulocyte-Macrophage Progenitor CellsHomeodomain ProteinsHumansLeukemia, Myeloid, AcuteMiceMice, Inbred C57BLModels, BiologicalMultiprotein ComplexesMyeloid Ecotropic Viral Integration Site 1 ProteinNeoplasm ProteinsPromoter Regions, GeneticProtein BindingTumor Suppressor Proteins