Drug Synergism Concept

subject area of

• 14 Antithrombotic treatment of cerebrovascular disease  Academic Article
• A Forward Chemical Screen Identifies Antibiotic Adjuvants in Escherichia coli  Academic Article
• A Review of Drug-Drug Interactions for Biologic Drugs Used in the Treatment of Psoriasis  Academic Article
• A novel synergistic effect of alanosine and guanine on adenine nucleotide synthesis in mammalian cells. Alanosine as a useful probe for investigating purine nucleotide metabolism  Academic Article
• AUGMENTATION STRATEGIES FOR TREATMENT-RESISTANT ANXIETY DISORDERS: A SYSTEMATIC REVIEW AND META-ANALYSIS  Academic Article
• Adding aspirin to clopidogrel after TIA and ischemic stroke: Benefits do not match risks  Academic Article
• Adenosine receptor blockade reveals N-methyl-d-aspartate receptor- and voltage-sensitive dendritic spikes in rat hippocampal CA1 pyramidal cells in vitro  Academic Article
• Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines  Academic Article
• Alpha 2-antiplasmin supplementation inhibits tissue plasminogen activator-induced fibrinogenolysis and bleeding with little effect on thrombolysis.  Academic Article
• An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens  Academic Article
• An alternative pathway for expression of p56lck from type I promoter transcripts in colon carcinoma  Academic Article
• An anti-inflammatory drug (BW755C) inhibits airway hyperresponsiveness induced by ozone in dogs  Academic Article
• An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria  Academic Article
• Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels  Academic Article
• Anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cell line  Academic Article
• Antibiotic Adjuvants: Rescuing Antibiotics from Resistance  Academic Article
• Antiplatelet Therapy for Secondary Prevention of Noncardioembolic Ischemic Stroke  Academic Article
• Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance  Academic Article
• Aspirin and fibrinolysis in acute myocardial infarction: Meta-analytic evidence for synergy  Academic Article
• Aspirin and other platelet-active drugs. The relationship between dose, effectiveness, and side effects.  Academic Article
• Augmentation of bovine airway smooth muscle responsiveness to carbachol, KCl, and histamine by the isoprostane 8-iso-PGE₂  Academic Article
• BF061, a novel antiplatelet and antithrombotic agent targeting P2Y12 receptor and phosphodiesterase  Academic Article
• Bicarbonate Alters Bacterial Susceptibility to Antibiotics by Targeting the Proton Motive Force  Academic Article
• Buspirone augmentation of selective serotonin reuptake inhibitors (SSRIs) in social phobia  Academic Article
• CNTF is superior to NGF as a survival enhancement factor for adrenal medulla cells in vitro  Academic Article
• Chemical Probes of Escherichia coli Uncovered through Chemical-Chemical Interaction Profiling with Compounds of Known Biological Activity  Academic Article
• Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane  Academic Article
• Cholera toxin increases IL-6 synthesis and decreases TNF-alpha production by rat peritoneal mast cells.  Academic Article
• Cimetidine potentiation of warfarin action.  Academic Article
• Clinical application of the concept of methotrexate plus 5-FU sequence-dependent "synergy": how good is the evidence?  Academic Article
• Collapsing the Proton Motive Force to Identify Synergistic Combinations against Staphylococcus aureus  Academic Article
• Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy  Academic Article
• Combinatorial strategies for combating invasive fungal infections  Academic Article
• Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells  Academic Article
• Combined coagulation phase-directed factor Xa inhibition with heparin compounds and DX-9065a - A direct and selective antagonist  Academic Article
• Concurrent administration of diethylhexyl phthalate reduces the threshold dose at which bisphenol A disrupts blastocyst implantation and cadherins in mice  Academic Article
• Continuous infusions of atracurium and vecuronium, compared with intermittent boluses of pancuronium: dose requirements and reversal  Academic Article
• Cooperation in signal transduction of extracellular guanosine 5′ triphosphate and nerve growth factor in neuronal differentiation of PC12 cells  Academic Article
• Cotreatment with the kappa opioid agonist U69593 enhances locomotor sensitization to the D2/D3 dopamine agonist quinpirole and alters dopamine D2 receptor and prodynorphin mRNA expression in rats  Academic Article
• Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice  Academic Article
• Cross‐species discovery of syncretic drug combinations that potentiate the antifungal fluconazole  Academic Article
• Cyclophosphamide, doxorubicin, and cisplatin in the treatment of non-small cell bronchogenic carcinoma.  Academic Article
• Deep learning identifies synergistic drug combinations for treating COVID-19  Academic Article
• Dexamethasone improves the efficacy of granisetron in the first 24 h following high-dose cisplatin chemotherapy  Academic Article
• Dexamethasone-Induced Abnormalities in Growth and Bone Metabolism in Piglets Are Partially Attenuated by Growth Hormone with No Synergistic Effect of Insulin-Like Growth Factor-I  Academic Article
• Disruption of blastocyst implantation by triclosan in mice: Impacts of repeated and acute doses and combination with bisphenol-A  Academic Article
• Dose-Dependent and Synergistic Effects of Proteoglycan 4 on Boundary Lubrication at a Human Cornea–Polydimethylsiloxane Biointerface  Academic Article
• Drug combinations: a strategy to extend the life of antibiotics in the 21st century  Academic Article
• Dual Pathway Inhibition for Vascular Protection in Patients with Atherosclerotic Disease: Rationale and Review of the Evidence  Academic Article
• Duvoglustat HCl Increases Systemic and Tissue Exposure of Active Acid α-Glucosidase in Pompe Patients Co-administered with Alglucosidase α  Academic Article
• Ecology of Danger-dependent Cytokine-boosted Spontaneous Abortion in the CBA × DBA/2 Mouse Model. I. Synergistic Effect of LPS and (TNF-α + IFN-γ) on Pregnancy Loss  Academic Article
• Effect of Nonspecific Binding to Plasma Proteins on the Antithrombin Activities of Unfractionated Heparin, Low-Molecular-Weight Heparin, and Dermatan Sulfate  Academic Article
• Effect of zoledronic acid on the doxycycline-induced decrease in tumour burden in a bone metastasis model of human breast cancer  Academic Article
• Effect of α-Lipoic Acid Combined with Creatine Monohydrate on Human Skeletal Muscle Creatine and Phosphagen Concentration  Academic Article
• Effects of Activators of Different Intracellular Signaling Pathways on Steroid Production by Goldfish Vitellogenic Ovarian Follicles  Academic Article
• Effects of external Ca2+ and Mg2+ on thrombin-induced changes in Ca2+ and Mg2+ of pig platelets  Article
• Effects of intranasal fluticasone and salmeterol on allergen-induced nasal responses  Academic Article
• Effects of salvinorin A on locomotor sensitization to D2/D3 dopamine agonist quinpirole  Academic Article
• Eicosanoid interactions in the canine proximal colon  Academic Article
• Emergence of muscle and neural hematopoiesis in humans  Academic Article
• Ethanol enhances the inhibitory effect of an oral GPIIb/IIIa antagonist on human platelet function  Academic Article
• Evidence against the role of α₁-adrenoceptor reserve in buffering the inhibitory effect of nifedipine on the contractility of canine vascular smooth muscle  Academic Article
• Fatty acids enhance membrane permeabilization by pro-apoptotic Bax  Academic Article
• Functional Expression of Neurokinin 1 Receptors on Mast Cells Induced by IL-4 and Stem Cell Factor  Academic Article
• GTP and guanosine synergistically enhance NGF-induced neurite outgrowth from PC12 cells  Academic Article
• Genetic risk factors associated with lipid-lowering drug-induced myopathies  Academic Article
• Grapefruit.  Academic Article
• Growth homone-dependent potentiation of gonadotropin-stimulated steroid production by ovarian follicles of the goldfish  Academic Article
• Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells  Academic Article
• Histamine stimulation of canine colonic epithelium: Potentiation by hydroxylamines  Academic Article
• Homocysteine-dependent Alterations in Mitochondrial Gene Expression, Function and Structure  Academic Article
• Hospitalization for Hemorrhage Among Warfarin Recipients Prescribed Amiodarone  Academic Article
• Hp and pH: Implications for the Eradication of Helicobacter pylori  Academic Article
• Hypertensive Pulmonary Vascular Disease Associated with Papain Emphysema in Rats  Academic Article
• IFN-gamma potentiates the accumulation of diacylglycerol in murine macrophages.  Academic Article
• Impact of the Combination of Daptomycin and Trimethoprim-Sulfamethoxazole on Clinical Outcomes in Methicillin-Resistant Staphylococcus aureus Infections  Academic Article
• Incorporation of cell-adhesion peptides into collagen scaffolds promotes corneal epithelial stratification  Academic Article
• Increased dipyridamole plasma concentrations associated with salicylate administration. Relationship to effects on platelet aggregation in vivo  Academic Article
• Inhibition of factor X and factor V activation by dermatan sulfate and a pentasaccharide with high affinity for antithrombin III in human plasma  Academic Article
• Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect  Academic Article
• Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin  Academic Article
• Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia  Academic Article
• Inhibition of tyrosine hydroxylase but not dopamine-β-hydroxylase facilitates the action of behaviourally ineffective doses of neuroleptics  Academic Article
• Insights into the role of thrombin in the pathogenesis of recurrent ischaemia after acute coronary syndrome  Academic Article
• Insulin as an Amplifier of Gonadotropin Action on Steroid Production: Mechanisms and Sites of Action in Goldfish Prematurational Full-Grown Ovarian Follicles  Academic Article
• Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells.  Academic Article
• Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock*  Academic Article
• Interactions of corneal epithelial cells and surfaces modified with cell adhesion peptide combinations  Academic Article
• Interactions of doxycycline with chemotherapeutic agents in human breast adenocarcinoma MDA-MB-231 cells  Academic Article
• Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: Implications for cartilage destruction and repair  Academic Article
• Involvement of phosphoinositide metabolism in potentiation by adrenaline of ADP-induced aggregation of rabbit platelets  Academic Article
• Is it safe to use long‑acting β‑agonists in asthma and chronic obstructive pulmonary disease? Implications of recent trials and meta‑analyses  Academic Article
• Kappa-Opioid Agonist U69593 Potentiates Locomotor Sensitization to the D2/D3 Agonist Quinpirole: Pre- and Postsynaptic Mechanisms  Academic Article
• M-CSF and 1,25 dihydroxy vitamin D3 synergize with 12-O-tetradecanoylphorbol-13-acetate to induce macrophage differentiation in acute promyelocytic leukemia NB4 cells.  Academic Article
• Mammary Gland Morphology in Sprague-Dawley Rats following Treatment with an Organochlorine Mixture in Utero and Neonatal Genistein  Academic Article
• Mechanism of catheter thrombosis: comparison of the antithrombotic activities of fondaparinux, enoxaparin, and heparin in vitro and in vivo  Academic Article
• Melatonin and steroids in human pre-ovulatory follicular fluid: seasonal variations and granulosa cell steroid production  Academic Article
• Meropenem potentiation of aminoglycoside activity against Pseudomonas aeruginosa: involvement of the MexXY-OprM multidrug efflux system  Academic Article
• Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity  Academic Article
• Miconazole Oral Gel Potentiates Warfarin Anticoagulant Activity  Academic Article
• Misoprostol as an adjunct to oxytocin can reduce postpartum-haemorrhage: a propensity score–matched retrospective chart review in Bamenda-Cameroon, 2015–2016  Academic Article
• Modulation of Dopamine Receptor Agonist-Induced Rotational Behavior in 6-OHDA-Lesioned Rats by a Peptidomimetic Analogue of Pro-Leu-Gly-NH2 (PLG)  Academic Article
• Multifactorial Regulation of Prostaglandin Synthesis in Preovulatory Goldfish Ovarian Follicles1  Academic Article
• Multiple sites and synergism in the binding of inhibitors to microsomal aminopeptidase  Academic Article
• Neuropeptides accentuate interleukin-4 induced human immunoglobuline E synthesis in vitro  Academic Article
• Novel approaches to discovery of antibacterial agents  Academic Article
• Nucleotide excision repair in the human ovarian carcinoma cell line (2008) and its cisplatin-resistant variant (C13*)  Academic Article
• Olanzapine plus fluoxetine treatment increases Nt-3 protein levels in the rat prefrontal cortex  Academic Article
• Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: Regulation of the type-II IL-4 receptor chains IL-4Rα and IL-13Rα1  Academic Article
• Oncostatin M in combination with tumor necrosis factor ? induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo  Academic Article
• PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer  Academic Article
• Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance  Academic Article
• Phenotypic differences in cholinergic responses of distal colonic epithelium  Academic Article
• Photodynamic Treatment: A Novel Method for Sanitation of Food Handling and Food Processing Surfaces  Academic Article
• Polyphenolic Extract from Maple Syrup Potentiates Antibiotic Susceptibility and Reduces Biofilm Formation of Pathogenic Bacteria  Academic Article
• Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component System  Academic Article
• Potentiation of chlorambucil toxicity in B-CLL lymphocytes using the DNA synthesis inhibitors aphidicolin and 1-β-d-arabinofuranosylcytosine  Academic Article
• Potentiation of long-acting β2-agonist and glucocorticoid responses in human airway epithelial cells by modulation of intracellular cAMP  Academic Article
• Pre-Diabetes Augments Neuropeptide Y1- and α1-Receptor Control of Basal Hindlimb Vascular Tone in Young ZDF Rats  Academic Article
• Probing the "active site" of diamine oxidase: structure-activity relations for histamine potentiation by O-alkylhydroxylamines on colonic epithelium.  Academic Article
• Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M  Academic Article
• Role of Secreted Adenosine Diphosphate in the Synergistic Effects of Cathepsin G on Human Platelets  Academic Article
• STIMULATION OF OSTEOCLAST DIFFERENTIATION IN VITRO BY MOUSE ONCOSTATIN M, LEUKAEMIA INHIBITORY FACTOR, CARDIOTROPHIN-1 AND INTERLEUKIN 6: SYNERGY WITH DEXAMETHASONE  Academic Article
• Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis  Academic Article
• Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound  Academic Article
• Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts  Academic Article
• Serotonin Syndrome Associated With Nefazodone and Paroxetine  Academic Article
• Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer  Academic Article
• Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin  Academic Article
• Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling  Academic Article
• Sodium butyrate and a T lymphocyte cell line-derived differentiation factor induce basophilic differentiation of the human promyelocytic leukemia cell line HL-60  Academic Article
• State of metabolic control determines role of epinephrine-glucagon interaction in glucoregulation in diabetes  Academic Article
• Stimulation of Nerve Fiber Growth from Cultured Sympathetic Explants  Academic Article
• Synergism between interleukins 1β and 6 on noradrenergic nerves in rat myenteric plexus  Academic Article
• Synergism between platelet aggregating agents: The role of the arachidonate pathway  Academic Article
• Synergistic actions of nitrovasodilators and isoprenaline on rat aortic smooth muscle  Academic Article
• Synergistic binding of inhibitors to the protease from HIV type 1  Academic Article
• Synergistic binding of ligands to angiotensin-converting enzyme.  Academic Article
• Synergistic effect of purine derivatives on the toxicity of pyrazofurin and 6-azauridine towards cultured mammalian cells  Academic Article
• Synergistic effects between FSH and 1,1-dichloro-2,2-bis(P-chlorophenyl)ethylene (P,P'-DDE) on human granulosa cell aromatase activity  Academic Article
• Synergistic effects of nerve growth factor and granulocyte-macrophage colony-stimulating factor on human basophilic cell differentiation  Academic Article
• Synergistic inhibitory effects of atriopeptin II and isoproterenol on contraction of rat aortic smooth muscle: roles of cGMP and cAMP  Academic Article
• Synergistic killing of Gram-negative bacilli by cefotaxime, its desacetyl metabolite and human polymorphonuclear neutrophils  Academic Article
• Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence  Academic Article
• Tetrandrine potentiates caffeine-induced contraction but inhibits phenylephrine-induced contraction in perfused rat mesenteric artery  Academic Article
• The Additive Effect of Topical Dorzolamide and Systemic Acetazolamide in Pediatric Glaucoma  Academic Article
• The Human Cationic Peptide LL-37 Induces Activation of the Extracellular Signal-Regulated Kinase and p38 Kinase Pathways in Primary Human Monocytes  Academic Article
• The Therapeutic Pipeline for Pseudomonas aeruginosa Infections  Academic Article
• The control of testicular androgen production in the goldfish: Effects of activators of different intracellular signalling pathways  Academic Article
• The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells  Academic Article
• The modulatory effects of WE-14 on histamine release from rat peritoneal mast cells.  Academic Article
• Topiramate augmentation in a patient with obsessive–compulsive disorder  Academic Article
• Topiramate augmentation in treatment-resistant obsessive–compulsive disorder: a retrospective, open-label case series  Academic Article
• Triclosan exacerbates the presence of 14C-bisphenol A in tissues of female and male mice  Academic Article
• Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems  Academic Article