Drug Synergism Concept

subject area of

• 14 Antithrombotic treatment of cerebrovascular disease  Journal Articles
• A Forward Chemical Screen Identifies Antibiotic Adjuvants in Escherichia coli  Journal Articles
• A Review of Drug-Drug Interactions for Biologic Drugs Used in the Treatment of Psoriasis  Journal Articles
• A longitudinal drug study and central amines.  Journal Articles
• A novel synergistic effect of alanosine and guanine on adenine nucleotide synthesis in mammalian cells. Alanosine as a useful probe for investigating purine nucleotide metabolism  Journal Articles
• A phase II study of erlotinib (OSI-774) given in combination with carboplatin in patients with recurrent epithelial ovarian cancer (NCIC CTG IND.149)  Journal Articles
• AUGMENTATION STRATEGIES FOR TREATMENT-RESISTANT ANXIETY DISORDERS: A SYSTEMATIC REVIEW AND META-ANALYSIS  Journal Articles
• Adding aspirin to clopidogrel after TIA and ischemic stroke  Journal Articles
• Adenosine receptor blockade reveals N-methyl-d-aspartate receptor- and voltage-sensitive dendritic spikes in rat hippocampal CA1 pyramidal cells in vitro  Journal Articles
• Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines  Journal Articles
• Alpha 2-antiplasmin supplementation inhibits tissue plasminogen activator-induced fibrinogenolysis and bleeding with little effect on thrombolysis.  Journal Articles
• An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens  Journal Articles
• An anti-inflammatory drug (BW755C) inhibits airway hyperresponsiveness induced by ozone in dogs  Journal Articles
• An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria  Journal Articles
• Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels  Journal Articles
• Anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cell line  Journal Articles
• Antibiotic Adjuvants: Rescuing Antibiotics from Resistance  Journal Articles
• Antiplatelet Therapy for Secondary Prevention of Noncardioembolic Ischemic Stroke  Journal Articles
• Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance  Journal Articles
• Aspirin and Other Platelet-Active Drugs  Journal Articles
• Aspirin and other platelet-active drugs. The relationship between dose, effectiveness, and side effects.  Journal Articles
• Augmentation of bovine airway smooth muscle responsiveness to carbachol, KCl, and histamine by the isoprostane 8-iso-PGE₂  Journal Articles
• BF061, a novel antiplatelet and antithrombotic agent targeting P2Y12 receptor and phosphodiesterase  Journal Articles
• Bicarbonate Alters Bacterial Susceptibility to Antibiotics by Targeting the Proton Motive Force  Journal Articles
• Buspirone augmentation of selective serotonin reuptake inhibitors (SSRIs) in social phobia  Journal Articles
• CNTF is superior to NGF as a survival enhancement factor for adrenal medulla cells in vitro  Journal Articles
• Chapter 11 Modulation of the effects of rewarding drugs by ibogaine  Journal Articles
• Chemical Probes of Escherichia coli Uncovered through Chemical-Chemical Interaction Profiling with Compounds of Known Biological Activity  Journal Articles
• Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane  Journal Articles
• Cholera toxin increases IL-6 synthesis and decreases TNF-alpha production by rat peritoneal mast cells.  Journal Articles
• Cimetidine potentiation of warfarin action.  Journal Articles
• Collapsing the Proton Motive Force to Identify Synergistic Combinations against Staphylococcus aureus  Journal Articles
• Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy  Journal Articles
• Combinatorial strategies for combating invasive fungal infections  Journal Articles
• Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells  Journal Articles
• Combined coagulation phase-directed factor Xa inhibition with heparin compounds and DX-9065a - A direct and selective antagonist  Journal Articles
• Concurrent administration of diethylhexyl phthalate reduces the threshold dose at which bisphenol A disrupts blastocyst implantation and cadherins in mice  Journal Articles
• Conditions Affecting the Responses of Human Platelets to Epinephrine  Journal Articles
• Continuous infusions of atracurium and vecuronium, compared with intermittent boluses of pancuronium: dose requirements and reversal  Journal Articles
• Cooperation in signal transduction of extracellular guanosine 5′ triphosphate and nerve growth factor in neuronal differentiation of PC12 cells  Journal Articles
• Cotreatment with the kappa opioid agonist U69593 enhances locomotor sensitization to the D2/D3 dopamine agonist quinpirole and alters dopamine D2 receptor and prodynorphin mRNA expression in rats  Journal Articles
• Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice  Journal Articles
• Cross‐species discovery of syncretic drug combinations that potentiate the antifungal fluconazole  Journal Articles
• Cyclophosphamide, doxorubicin, and cisplatin in the treatment of non-small cell bronchogenic carcinoma.  Journal Articles
• Deep learning identifies synergistic drug combinations for treating COVID-19  Journal Articles
• Dexamethasone improves the efficacy of granisetron in the first 24 h following high-dose cisplatin chemotherapy  Journal Articles
• Dexamethasone-Induced Abnormalities in Growth and Bone Metabolism in Piglets Are Partially Attenuated by Growth Hormone with No Synergistic Effect of Insulin-Like Growth Factor-I  Journal Articles
• Disruption of blastocyst implantation by triclosan in mice: Impacts of repeated and acute doses and combination with bisphenol-A  Journal Articles
• Dose-Dependent and Synergistic Effects of Proteoglycan 4 on Boundary Lubrication at a Human Cornea–Polydimethylsiloxane Biointerface  Journal Articles
• Drug combinations: a strategy to extend the life of antibiotics in the 21st century  Journal Articles
• Dual Pathway Inhibition for Vascular Protection in Patients with Atherosclerotic Disease: Rationale and Review of the Evidence  Journal Articles
• Duvoglustat HCl Increases Systemic and Tissue Exposure of Active Acid α-Glucosidase in Pompe Patients Co-administered with Alglucosidase α  Journal Articles
• Ecology of Danger‐dependent Cytokine‐boosted Spontaneous Abortion in the CBA × DBA/2 Mouse Model. I. Synergistic Effect of LPS and (TNF‐α + IFN‐γ) on Pregnancy Loss  Journal Articles
• Effect of Nonspecific Binding to Plasma Proteins on the Antithrombin Activities of Unfractionated Heparin, Low-Molecular-Weight Heparin, and Dermatan Sulfate  Journal Articles
• Effect of zoledronic acid on the doxycycline-induced decrease in tumour burden in a bone metastasis model of human breast cancer  Journal Articles
• Effect of α-Lipoic Acid Combined with Creatine Monohydrate on Human Skeletal Muscle Creatine and Phosphagen Concentration  Journal Articles
• Effects of Activators of Different Intracellular Signaling Pathways on Steroid Production by Goldfish Vitellogenic Ovarian Follicles  Journal Articles
• Effects of external Ca2+ and Mg2+ on thrombin-induced changes in Ca2+ and Mg2+ of pig platelets  Other
• Effects of intranasal fluticasone and salmeterol on allergen‐induced nasal responses  Journal Articles
• Effects of salvinorin A on locomotor sensitization to D2/D3 dopamine agonist quinpirole  Journal Articles
• Eicosanoid interactions in the canine proximal colon  Journal Articles
• Emergence of muscle and neural hematopoiesis in humans  Journal Articles
• Ethanol enhances the inhibitory effect of an oral GPIIb/IIIa antagonist on human platelet function  Journal Articles
• Evidence against the role of α₁-adrenoceptor reserve in buffering the inhibitory effect of nifedipine on the contractility of canine vascular smooth muscle  Journal Articles
• Functional Expression of Neurokinin 1 Receptors on Mast Cells Induced by IL-4 and Stem Cell Factor  Journal Articles
• GTP and guanosine synergistically enhance NGF‐induced neurite outgrowth from PC12 cells  Journal Articles
• Genetic risk factors associated with lipid‐lowering drug‐induced myopathies  Journal Articles
• Grapefruit.  Journal Articles
• Growth homone-dependent potentiation of gonadotropin-stimulated steroid production by ovarian follicles of the goldfish  Journal Articles
• Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells  Journal Articles
• Histamine stimulation of canine colonic epithelium: Potentiation by hydroxylamines  Journal Articles
• Homocysteine-dependent Alterations in Mitochondrial Gene Expression, Function and Structure  Journal Articles
• Hospitalization for Hemorrhage Among Warfarin Recipients Prescribed Amiodarone  Journal Articles
• Hp and pH: Implications for the Eradication of Helicobacter pylori  Journal Articles
• IFN-gamma potentiates the accumulation of diacylglycerol in murine macrophages.  Journal Articles
• Impact of the Combination of Daptomycin and Trimethoprim-Sulfamethoxazole on Clinical Outcomes in Methicillin-Resistant Staphylococcus aureus Infections  Journal Articles
• Incorporation of cell-adhesion peptides into collagen scaffolds promotes corneal epithelial stratification  Journal Articles
• Increased dipyridamole plasma concentrations associated with salicylate administration. Relationship to effects on platelet aggregation in vivo  Journal Articles
• Inhibition of factor X and factor V activation by dermatan sulfate and a pentasaccharide with high affinity for antithrombin III in human plasma  Journal Articles
• Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect  Journal Articles
• Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin  Journal Articles
• Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia  Journal Articles
• Inhibition of tyrosine hydroxylase but not dopamine-β-hydroxylase facilitates the action of behaviourally ineffective doses of neuroleptics  Journal Articles
• Insights into the role of thrombin in the pathogenesis of recurrent ischaemia after acute coronary syndrome  Journal Articles
• Insulin as an Amplifier of Gonadotropin Action on Steroid Production: Mechanisms and Sites of Action in Goldfish Prematurational Full-Grown Ovarian Follicles  Journal Articles
• Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells.  Journal Articles
• Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock*  Journal Articles
• Interactions of corneal epithelial cells and surfaces modified with cell adhesion peptide combinations  Journal Articles
• Interactions of doxycycline with chemotherapeutic agents in human breast adenocarcinoma MDA-MB-231 cells  Journal Articles
• Interleukin‐1 in combination with oncostatin M up‐regulates multiple genes in chondrocytes: Implications for cartilage destruction and repair  Journal Articles
• Involvement of phosphoinositide metabolism in potentiation by adrenaline of ADP-induced aggregation of rabbit platelets  Journal Articles
• Is it safe to use long‑acting β‑agonists in asthma and chronic obstructive pulmonary disease? Implications of recent trials and meta‑analyses  Journal Articles
• Kappa-Opioid Agonist U69593 Potentiates Locomotor Sensitization to the D2/D3 Agonist Quinpirole: Pre- and Postsynaptic Mechanisms  Journal Articles
• M-CSF and 1,25 dihydroxy vitamin D3 synergize with 12-O-tetradecanoylphorbol-13-acetate to induce macrophage differentiation in acute promyelocytic leukemia NB4 cells.  Journal Articles
• Mammary Gland Morphology in Sprague-Dawley Rats following Treatment with an Organochlorine Mixture in Utero and Neonatal Genistein  Journal Articles
• Mechanism of catheter thrombosis: comparison of the antithrombotic activities of fondaparinux, enoxaparin, and heparin in vitro and in vivo  Journal Articles
• Melatonin and steroids in human pre-ovulatory follicular fluid: seasonal variations and granulosa cell steroid production  Journal Articles
• Meropenem potentiation of aminoglycoside activity against Pseudomonas aeruginosa: involvement of the MexXY-OprM multidrug efflux system  Journal Articles
• Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity  Journal Articles
• Miconazole Oral Gel Potentiates Warfarin Anticoagulant Activity  Journal Articles
• Misoprostol as an adjunct to oxytocin can reduce postpartum-haemorrhage: a propensity score–matched retrospective chart review in Bamenda-Cameroon, 2015–2016  Journal Articles
• Modulation of Dopamine Receptor Agonist-Induced Rotational Behavior in 6-OHDA-Lesioned Rats by a Peptidomimetic Analogue of Pro-Leu-Gly-NH2 (PLG)  Journal Articles
• Multifactorial Regulation of Prostaglandin Synthesis in Preovulatory Goldfish Ovarian Follicles1  Journal Articles
• Multiple sites and synergism in the binding of inhibitors to microsomal aminopeptidase  Journal Articles
• Neuropeptides accentuate interleukin‐4 induced human immunoglobuline E synthesis in vitro  Journal Articles
• Non-chemotherapeutic agents that potentiate chemotherapy efficacy  Journal Articles
• Norepinephrine Inhibits Macrophage Migration by Decreasing CCR2 Expression  Journal Articles
• Novel approaches to discovery of antibacterial agents  Journal Articles
• Nucleotide excision repair in the human ovarian carcinoma cell line (2008) and its cisplatin-resistant variant (C13*)  Journal Articles
• Olanzapine plus fluoxetine treatment increases Nt-3 protein levels in the rat prefrontal cortex  Journal Articles
• Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: Regulation of the type-II IL-4 receptor chains IL-4Rα and IL-13Rα1  Journal Articles
• Oncostatin M in combination with tumor necrosis factor α induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo  Journal Articles
• PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer  Journal Articles
• Paclitaxel plus hydroxyurea as second line therapy for non-small cell lung cancer  Journal Articles
• Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance  Journal Articles
• Phenotypic differences in cholinergic responses of distal colonic epithelium  Journal Articles
• Photodynamic Treatment: A Novel Method for Sanitation of Food Handling and Food Processing Surfaces  Journal Articles
• Polyphenolic Extract from Maple Syrup Potentiates Antibiotic Susceptibility and Reduces Biofilm Formation of Pathogenic Bacteria  Journal Articles
• Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component System  Journal Articles
• Potentiation of chlorambucil toxicity in B-CLL lymphocytes using the DNA synthesis inhibitors aphidicolin and 1-β-d-arabinofuranosylcytosine  Journal Articles
• Potentiation of long-acting β2-agonist and glucocorticoid responses in human airway epithelial cells by modulation of intracellular cAMP  Journal Articles
• Pre-Diabetes Augments Neuropeptide Y1- and α1-Receptor Control of Basal Hindlimb Vascular Tone in Young ZDF Rats  Journal Articles
• Pretreatment of Human Platelets with Plasmin Inhibits Responses toThrombin, but Potentiates Responses to Low Concentrations of Aggregating Agents, Including the Thrombin Receptor Activating Peptide, SFLLRN  Journal Articles
• Probenecid Inhibits Platelet Responses to Aggregating Agents in Vitro and Has a Synergistic Inhibitory Effect with Penicillin G  Journal Articles
• Probing the "active site" of diamine oxidase: structure-activity relations for histamine potentiation by O-alkylhydroxylamines on colonic epithelium.  Journal Articles
• Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M  Journal Articles
• Role of Secreted Adenosine Diphosphate in the Synergistic Effects of Cathepsin G on Human Platelets  Journal Articles
• STIMULATION OF OSTEOCLAST DIFFERENTIATION IN VITRO BY MOUSE ONCOSTATIN M, LEUKAEMIA INHIBITORY FACTOR, CARDIOTROPHIN-1 AND INTERLEUKIN 6: SYNERGY WITH DEXAMETHASONE  Journal Articles
• Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis  Journal Articles
• Selenium-deposited tripterine phytosomes ameliorate the antiarthritic efficacy of the phytomedicine via a synergistic sensitization  Journal Articles
• Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound  Journal Articles
• Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts  Journal Articles
• Serotonin Syndrome Associated With Nefazodone and Paroxetine  Journal Articles
• Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer  Journal Articles
• Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin  Journal Articles
• Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling  Journal Articles
• Sodium butyrate and a T lymphocyte cell line-derived differentiation factor induce basophilic differentiation of the human promyelocytic leukemia cell line HL-60  Journal Articles
• Stimulation of Nerve Fiber Growth from Cultured Sympathetic Explants  Journal Articles
• Synergism between interleukins 1β and 6 on noradrenergic nerves in rat myenteric plexus  Journal Articles
• Synergism between platelet aggregating agents: The role of the arachidonate pathway  Journal Articles
• Synergistic actions of nitrovasodilators and isoprenaline on rat aortic smooth muscle  Journal Articles
• Synergistic binding of inhibitors to the protease from HIV type 1  Journal Articles
• Synergistic binding of ligands to angiotensin-converting enzyme.  Journal Articles
• Synergistic effect of purine derivatives on the toxicity of pyrazofurin and 6‐azauridine towards cultured mammalian cells  Journal Articles
• Synergistic effects between FSH and 1,1-dichloro-2,2-bis(P-chlorophenyl)ethylene (P,P'-DDE) on human granulosa cell aromatase activity  Journal Articles
• Synergistic effects of nerve growth factor and granulocyte-macrophage colony-stimulating factor on human basophilic cell differentiation  Journal Articles
• Synergistic inhibitory effects of atriopeptin II and isoproterenol on contraction of rat aortic smooth muscle: roles of cGMP and cAMP  Journal Articles
• Synergistic killing of Gram-negative bacilli by cefotaxime, its desacetyl metabolite and human polymorphonuclear neutrophils  Journal Articles
• Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence  Journal Articles
• Temperate phage-antibiotic synergy across antibiotic classes reveals new mechanism for preventing lysogeny  Journal Articles
• Tetrandrine potentiates caffeine-induced contraction but inhibits phenylephrine-induced contraction in perfused rat mesenteric artery  Journal Articles
• The Additive Effect of Topical Dorzolamide and Systemic Acetazolamide in Pediatric Glaucoma  Journal Articles
• The Human Cationic Peptide LL-37 Induces Activation of the Extracellular Signal-Regulated Kinase and p38 Kinase Pathways in Primary Human Monocytes  Journal Articles
• The Therapeutic Pipeline for Pseudomonas aeruginosa Infections  Journal Articles
• The control of testicular androgen production in the goldfish: Effects of activators of different intracellular signalling pathways  Journal Articles
• The effects of chlorhexidine, povidone-iodine and vancomycin on growth and biofilms of pathogens that cause prosthetic joint infections: an in-vitro model  Journal Articles
• The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells  Journal Articles
• Topiramate augmentation in a patient with obsessive–compulsive disorder  Journal Articles
• Topiramate augmentation in treatment-resistant obsessive–compulsive disorder: a retrospective, open-label case series  Journal Articles
• Triclosan exacerbates the presence of 14C-bisphenol A in tissues of female and male mice  Journal Articles
• Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems  Journal Articles