Journal article
Cotreatment with the kappa opioid agonist U69593 enhances locomotor sensitization to the D2/D3 dopamine agonist quinpirole and alters dopamine D2 receptor and prodynorphin mRNA expression in rats
Abstract
RationaleThe repeated coadministration of the kappa opioid receptor agonist U69593 with the D2/D3 dopamine (DA) agonist quinpirole (QNP) potentiates locomotor sensitization induced by QNP. Behavioral evidence has implicated both pre- and postsynaptic changes as being involved in this augmentation.ObjectivesThe objectives of this study were to obtain supporting molecular evidence of pre- and/or postsynaptic alterations in the DA system with …
Authors
Perreault ML; Graham D; Scattolon S; Wang Y; Szechtman H; Foster JA
Journal
Psychopharmacology, Vol. 194, No. 4, pp. 485–496
Publisher
Springer Nature
Publication Date
November 2007
DOI
10.1007/s00213-007-0855-3
ISSN
0033-3158
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnalgesicsAnalysis of VarianceAnimalsAutoradiographyBasal GangliaBenzeneacetamidesDopamine AgonistsDopamine AntagonistsDrug SynergismEnkephalinsGene ExpressionIn Situ HybridizationInjectionsMaleMotor ActivityProtein PrecursorsPyrrolidinesQuinpiroleRNA, MessengerRatsRats, Long-EvansReceptors, Dopamine D2Receptors, Opioid, kappaSulfur IsotopesTime Factors