Journal article
The Human Cationic Peptide LL-37 Induces Activation of the Extracellular Signal-Regulated Kinase and p38 Kinase Pathways in Primary Human Monocytes
Abstract
LL-37 is a cationic peptide that is found in the granules of neutrophils and is secreted by epithelial cells from a variety of tissues. Levels of LL-37 in vivo increase upon infection, and its production and secretion are increased upon stimulation with proinflammatory mediators. It has been postulated that LL-37 modulates the immune response by interacting with the effector cells of innate immunity; however, the mechanism of this interaction …
Authors
Bowdish DME; Davidson DJ; Speert DP; Hancock REW
Journal
The Journal of Immunology, Vol. 172, No. 6, pp. 3758–3765
Publisher
Oxford University Press (OUP)
Publication Date
March 15, 2004
DOI
10.4049/jimmunol.172.6.3758
ISSN
0022-1767
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Antimicrobial Cationic PeptidesCathelicidinsCells, CulturedChemokinesCytotoxicity, ImmunologicDose-Response Relationship, ImmunologicDrug SynergismEnzyme ActivationEpithelial CellsGTP-Binding ProteinsGene Expression RegulationGranulocyte-Macrophage Colony-Stimulating FactorHumansInterleukin-8MAP Kinase Signaling SystemMacrophage ActivationMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesMonocytesReceptor, EphA8Transcription, Geneticp38 Mitogen-Activated Protein Kinases