Journal article
Dose-Dependent and Synergistic Effects of Proteoglycan 4 on Boundary Lubrication at a Human Cornea–Polydimethylsiloxane Biointerface
Abstract
OBJECTIVES: Proteoglycan 4 (PRG4), also known as lubricin, is a boundary lubricating mucin-like glycoprotein present on several tissue surfaces in the body. The objectives of this study were to (1) implement and characterize an in vitro boundary lubrication test at a human cornea-polydimethylsiloxane (PDMS) biointerface and (2) determine the dose-dependent and synergistic effects of PRG4, with hyaluronan (HA), on ocular surface boundary …
Authors
Morrison S; Sullivan DA; Sullivan BD; Sheardown H; Schmidt TA
Journal
Eye & Contact Lens Science & Clinical Practice, Vol. 38, No. 1, pp. 27–35
Publisher
Wolters Kluwer
Publication Date
January 2012
DOI
10.1097/icl.0b013e31823f7041
ISSN
1542-2321