Journal article
Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells
Abstract
The combination of interleukin (IL)-18 and IL-12 (IL-18+IL-12) potently stimulates natural killer (NK) cells, triggering an innate immune response to infections and cancers. Strategies exploiting the effects of IL-18+IL-12 have shown promise for cancer immunotherapy. However, studies have primarily characterized the NK cell response to IL-18+IL-12 in terms of interferon (IFN)-γ production, with little focus on other cytokines produced. IL-8 …
Authors
Poznanski SM; Lee AJ; Nham T; Lusty E; Larché MJ; Lee DA; Ashkar AA
Journal
Journal of Innate Immunity, Vol. 9, No. 5, pp. 511–525
Publisher
Karger Publishers
Publication Date
2017
DOI
10.1159/000477172
ISSN
1662-811X