Journal article
Perturbation of Pseudomonas aeruginosa peptidoglycan recycling by anti-folates and design of a dual-action inhibitor
Abstract
Peptidoglycan (PG) is an important bacterial macromolecule that confers cell shape and structural integrity, and is a key antibiotic target. Its synthesis and turnover are carefully coordinated with other cellular processes and pathways. Despite established connections between the biosynthesis of PG and the outer membrane, or PG and DNA replication, links between PG and folate metabolism remain comparatively unexplored. Folate is an essential …
Authors
Yaeger LN; Sychantha D; Luong P; Shekarriz S; Goncalves O; Dobrin A; Ranieri MR; Lamers RP; Harvey H; diCenzo GC
Journal
mBio, Vol. 16, No. 3, pp. e02984–e02924
Publisher
American Society for Microbiology
Publication Date
March 12, 2025
DOI
10.1128/mbio.02984-24
ISSN
2161-2129