Journal article
Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M
Abstract
BackgroundRegulation of human airway smooth muscle cells (HASMC) by cytokines contributes to chemotactic factor levels and thus to inflammatory cell accumulation in lung diseases. Cytokines such as the gp130 family member Oncostatin M (OSM) can act synergistically with Th2 cytokines (IL-4 and IL-13) to modulate lung cells, however whether IL-17A responses by HASMC can be altered is not known.ObjectiveTo determine the effects of recombinant OSM, …
Authors
Kwofie K; Scott M; Rodrigues R; Guerette J; Radford K; Nair P; Richards CD
Journal
Respiratory Research, Vol. 16, No. 1,
Publisher
Springer Nature
Publication Date
December 2015
DOI
10.1186/s12931-014-0164-4
ISSN
1465-9921
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Cells, CulturedChemokine CCL2Dose-Response Relationship, DrugDrug SynergismEnzyme ActivationGene Expression RegulationHumansInterleukin-17Interleukin-6Myocytes, Smooth MuscleOncostatin MPhosphorylationProtein Kinase InhibitorsProto-Oncogene Proteins c-aktRNA, MessengerRespiratory SystemSTAT3 Transcription FactorSignal Transductionp38 Mitogen-Activated Protein Kinases