AMP-Activated Protein Kinases Concept

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• AMPK β1 reduces tumor progression and improves survival in p53 null mice  Journal Articles
• A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease  Journal Articles
• AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5  Journal Articles
• AMP-Activated Protein Kinase-Regulated Activation of the PGC-1α Promoter in Skeletal Muscle Cells  Journal Articles
• AMP-activated protein kinase (AMPK) beyond metabolism  Journal Articles
• AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise  Journal Articles
• AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats  Journal Articles
• AMP-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in Duchenne muscular dystrophy  Journal Articles
• AMP-activated protein kinase — the fat controller of the energy railroadThis paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference.  Journal Articles
• AMP-activated protein kinase, fatty acid metabolism, and insulin sensitivity  Journal Articles
• AMP-activated protein kinase: the current landscape for drug development  Journal Articles
• AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging  Journal Articles
• AMPK and the Endocrine Control of Metabolism  Journal Articles
• AMPK and the endocrine control of energy metabolism  Journal Articles
• AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism  Journal Articles
• AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment  Journal Articles
• AMPK in Health and Disease  Journal Articles
• AMPK is mitochondrial medicine for neuromuscular disorders  Journal Articles
• AMPK mediates energetic stress‐induced liver GDF15  Journal Articles
• AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice  Journal Articles
• AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease  Journal Articles
• AMPK regulates the maintenance and remodelling of the neuromuscular junction.  Journal Articles
• AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity  Journal Articles
• AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis  Journal Articles
• AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation  Journal Articles
• AMPK-Dependent Inhibitory Phosphorylation of ACC Is Not Essential for Maintaining Myocardial Fatty Acid Oxidation  Journal Articles
• AMPK: mediating the metabolic effects of salicylate-based drugs?  Journal Articles
• AMPK‐dependent hormonal regulation of whole‐body energy metabolism  Journal Articles
• AMPK‐independent pathways regulate skeletal muscle fatty acid oxidation  Journal Articles
• AMP‐activated protein kinase is required for exercise‐induced peroxisome proliferator‐activated receptor γ co‐activator 1α translocation to subsarcolemmal mitochondria in skeletal muscle  Journal Articles
• AXIN-AMPK signaling: Implications for healthy aging  Journal Articles
• Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models  Journal Articles
• Acute, next‐generation AMPK activation initiates a disease‐resistant gene expression program in dystrophic skeletal muscle  Journal Articles
• Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats  Journal Articles
• Adiponectin: Starving for Attention  Journal Articles
• Age-related expression of prominent regulatory elements in mouse brain: catastrophic decline of FOXO3a  Journal Articles
• An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice  Journal Articles
• Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?  Journal Articles
• Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis  Journal Articles
• Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK  Journal Articles
• Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle  Journal Articles
• Burn Plus Lipopolysaccharide Augments Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation and Reduces PGC-1α in Liver  Journal Articles
• CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK  Journal Articles
• Carbohydrate feeding during recovery alters the skeletal muscle metabolic response to repeated sessions of high-intensity interval exercise in humans  Journal Articles
• Cellular Energy Sensing and Metabolism—Implications for Treating Diabetes: The 2017 Outstanding Scientific Achievement Award Lecture  Journal Articles
• Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle  Journal Articles
• Chronic AMPK stimulation attenuates adaptive signaling in dystrophic skeletal muscle  Journal Articles
• Cigarette Smoke Exposure Triggers the Autophagic Cascade via Activation of the AMPK Pathway in Mice1  Journal Articles
• Ciliary Neurotrophic Factor Suppresses Hypothalamic AMP-Kinase Signaling in Leptin-Resistant Obese Mice  Journal Articles
• Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress  Journal Articles
• Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle  Journal Articles
• Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent  Journal Articles
• Contraction-related stimuli regulate GLUT4 traffic in C₂C₁₂-GLUT4mycskeletal muscle cells  Journal Articles
• Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise  Journal Articles
• Cytokine Regulation of AMPK signalling  Journal Articles
• Diminished contraction‐induced intracellular signaling towards mitochondrial biogenesis in aged skeletal muscle  Journal Articles
• Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis  Journal Articles
• Editorial: “Presenting” an adaptive role for AMPK  Journal Articles
• Emerging Role of AMPK in Brown and Beige Adipose Tissue (BAT): Implications for Obesity, Insulin Resistance, and Type 2 Diabetes  Journal Articles
• Energy-stress-mediated AMPK activation inhibits ferroptosis  Journal Articles
• Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662  Journal Articles
• Establishing a relationship between prolactin and altered fatty acid β-Oxidation via carnitine palmitoyl transferase 1 in breast cancer cells  Journal Articles
• Evidence for the role of AMPK in regulating PGC‐1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue  Journal Articles
• Exercise-induced Protein Arginine Methyltransferase Expression in Skeletal Muscle  Journal Articles
• Exercise-specific adaptations in human skeletal muscle: Molecular mechanisms of making muscles fit and mighty.  Journal Articles
• Exercise‐stimulated interleukin‐15 is controlled byAMPKand regulates skin metabolism and aging  Journal Articles
• Exercising women throw a wrench in the gears of the AMPK–lipid oxidation link  Journal Articles
• Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men  Journal Articles
• Genomic and Metabolic Preparation of Muscle in Sockeye SalmonOncorhynchus nerkafor Spawning Migration  Journal Articles
• Glutamate increases glucose uptake in L6 myotubes in a concentration- and time-dependent manner that is mediated by AMPK  Journal Articles
• Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity  Journal Articles
• High-Density Lipoprotein Modulates Glucose Metabolism in Patients With Type 2 Diabetes Mellitus  Journal Articles
• Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo  Journal Articles
• IL-6 is not essential for exercise-induced increases in glucose uptake  Journal Articles
• Immunometabolism of AMPK in insulin resistance and atherosclerosis  Journal Articles
• Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation  Journal Articles
• Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release  Journal Articles
• Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators  Journal Articles
• Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells  Journal Articles
• Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase  Journal Articles
• Intermittent and continuous high‐intensity exercise training induce similar acute but different chronic muscle adaptations  Journal Articles
• Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells  Journal Articles
• Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells  Journal Articles
• Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function  Journal Articles
• Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms  Journal Articles
• Low salt concentrations activate AMP-activated protein kinase in mouse macula densa cells  Journal Articles
• Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle  Journal Articles
• Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants  Journal Articles
• Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK  Journal Articles
• Mechanisms of exercise‐induced survival motor neuron expression in the skeletal muscle of spinal muscular atrophy‐like mice  Journal Articles
• Metformin adapts its cellular effects to bioenergetic status in a model of metabolic dysfunction  Journal Articles
• Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity  Journal Articles
• Metformin prevents the pathological browning of subcutaneous white adipose tissue  Journal Articles
• MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis  Journal Articles
• Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy  Journal Articles
• Molecular responses to high-intensity interval exerciseThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.  Journal Articles
• Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate  Journal Articles
• Muscle‐specific AMPK β1β2‐null mice display a myopathy due to loss of capillary density in nonpostural muscles  Journal Articles
• Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site  Journal Articles
• New insights into activation and function of the AMPK  Journal Articles
• Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle  Journal Articles
• PIKfyve: a new fish in the growing pool of AMPK substrates  Journal Articles
• Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARα and UCP2 expression in rats  Journal Articles
• Protein arginine methyltransferase expression, localization, and activity during disuse-induced skeletal muscle plasticity  Journal Articles
• Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise  Journal Articles
• Reduced glycogen availability is associated with increased AMPKα2 activity, nuclear AMPKα2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle  Journal Articles
• Reduced skeletal muscle AMPK and mitochondrial markers do not promote age-induced insulin resistance  Journal Articles
• Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue  Journal Articles
• Regulation of glucose transporter 4 traffic by energy deprivation from mitochondrial compromise  Journal Articles
• Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways  Journal Articles
• Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis  Journal Articles
• Role of the AMP-activated protein kinase in regulating fatty acid metabolism during exerciseThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.  Journal Articles
• SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol  Journal Articles
• Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis  Journal Articles
• Salicylate improves macrophage cholesterol homeostasis via activation of Ampk  Journal Articles
• Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK  Journal Articles
• Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1  Journal Articles
• Salsalate reduces atherosclerosis through AMPKβ1 in mice  Journal Articles
• Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease  Journal Articles
• Sensing of Long-Chain Fatty Acyl-CoA Esters by AMPK.  Journal Articles
• Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells  Journal Articles
• Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin  Journal Articles
• Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling  Journal Articles
• Specific attenuation of protein kinase phosphorylation in muscle with a high mitochondrial content  Journal Articles
• Suppression of neuronal AMPKβ2 isoform impairs recognition memory and synaptic plasticity.  Journal Articles
• Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer  Journal Articles
• The AMP-Activated Protein Kinase: Role in Regulation of Skeletal Muscle Metabolism and Insulin Sensitivity  Journal Articles
• The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase  Journal Articles
• The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels  Journal Articles
• The Role of AMPK in Neuromuscular Biology and Disease  Journal Articles
• The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice  Journal Articles
• The Stimulatory Effect of Globular Adiponectin on Insulin-Stimulated Glucose Uptake and Fatty Acid Oxidation Is Impaired in Skeletal Muscle From Obese Subjects  Journal Articles
• The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs  Journal Articles
• The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK  Journal Articles
• The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway  Journal Articles
• The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids  Journal Articles
• The role of AMP‐activated protein kinase in the expression of the dystrophin‐associated protein complex in skeletal muscle  Journal Articles
• The therapeutic potential of skeletal muscle plasticity in Duchenne muscular dystrophy: phenotypic modifiers as pharmacologic targets  Journal Articles
• Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes  Journal Articles
• To Elucidate the Inhibition of Excessive Autophagy of <i>Rhodiola crenulata</i> on Exhaustive Exercise-Induced Skeletal Muscle Injury by Combined Network Pharmacology and Molecular Docking  Journal Articles
• Transcriptome and translational signaling following endurance exercise in trained skeletal muscle: impact of dietary protein  Journal Articles
• Treatment of nonalcoholic fatty liver disease: role of AMPK  Journal Articles
• Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo  Journal Articles
• Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation  Journal Articles
• Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity  Journal Articles
• β‐adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling  Journal Articles