Journal article
Metformin adapts its cellular effects to bioenergetic status in a model of metabolic dysfunction
Abstract
Thermal injury induces a complex immunometabolic response, characterized by hyperglycemia, extensive inflammation and persistent hypermetabolism. It has been suggested that attenuation of the hypermetabolic response is beneficial for patient wellbeing. To that effect, metformin represents an attractive therapeutic agent, as its effects on glycemia, inflammation and bioenergetics can improve outcomes in burn patients. Therefore, we studied …
Authors
Auger C; Sivayoganathan T; Abdullahi A; Parousis A; Pang BW; Jeschke MG
Journal
Scientific Reports, Vol. 8, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41598-018-24017-7
ISSN
2045-2322