Journal article
Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle
Abstract
The aim of the present study was to test the hypothesis that acute high-intensity interval (HIT) running induces greater activation of signaling pathways associated with mitochondrial biogenesis compared with moderate-intensity continuous (CONT) running matched for work done. In a repeated-measures design, 10 active men performed two running protocols consisting of HIT [6 × 3-min at 90% maximal oxygen consumption (Vo(2max)) interspersed with …
Authors
Bartlett JD; Joo CH; Jeong T-S; Louhelainen J; Cochran AJ; Gibala MJ; Gregson W; Close GL; Drust B; Morton JP
Journal
Journal of Applied Physiology, Vol. 112, No. 7, pp. 1135–1143
Publisher
American Physiological Society
Publication Date
April 1, 2012
DOI
10.1152/japplphysiol.01040.2011
ISSN
8750-7587
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AMP-Activated Protein KinasesAnaerobic ThresholdBiopsyBlood Chemical AnalysisBlotting, WesternCalcium SignalingCross-Over StudiesHSP72 Heat-Shock ProteinsHeart RateHeat-Shock ProteinsHumansLactic AcidMaleMuscle, SkeletalOxygen ConsumptionPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhosphorylationRNA, MessengerReal-Time Polymerase Chain ReactionRunningSuperoxide DismutaseTranscription FactorsTumor Suppressor Protein p53Young Adultp38 Mitogen-Activated Protein Kinases