Journal article
Burn Plus Lipopolysaccharide Augments Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation and Reduces PGC-1&agr; in Liver
Abstract
Extensively burned patients often suffer from sepsis (especially caused by Pseudomonas aeruginosa), which may prolong metabolic derangement, contribute to multiple organ failure, and increase mortality. The molecular and cellular mechanisms of such infection-related metabolic derangement and organ dysfunction are unclear. We have previously shown that severely burned patients have significant and persisting hepatic endoplasmic reticulum (ER) …
Authors
Diao L; Marshall AH; Dai X; Bogdanovic E; Abdullahi A; Amini-Nik S; Jeschke MG
Journal
Shock, Vol. 41, No. 2, pp. 138–144
Publisher
Wolters Kluwer
Publication Date
February 2014
DOI
10.1097/shk.0000000000000075
ISSN
1073-2322
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AMP-Activated Protein KinasesAnimalsBurnsCarrier ProteinsEndoplasmic Reticulum StressInflammasomesLipopolysaccharidesLiverLiver DiseasesMaleNLR Family, Pyrin Domain-Containing 3 ProteinPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPseudomonas aeruginosaRatsReceptors, Cytoplasmic and NuclearSirtuin 1Transcription Factors