The Role of AMPK in Neuromuscular Biology and Disease Journal Articles

abstract

• AMP-activated protein kinase (AMPK) is a primary regulator of cellular metabolism. Recent studies have revealed that AMPK also mediates the maintenance and plasticity of α-motoneurons, the neuromuscular junction, and skeletal muscle. Furthermore, AMPK stimulation by either genetic, pharmacological, or physiological approaches elicits beneficial phenotypic remodeling in neuromuscular disorders (NMDs). Here, we review the role of AMPK as a governor of neuromuscular biology, and present evidence for AMPK as an effective molecular target for therapeutic pursuit in the context of the most prevalent NMDs, including Duchenne muscular dystrophy, spinal muscular atrophy, and myotonic dystrophy type 1. This information may be useful for engineering AMPK-targeted pharmacological- or lifestyle-based strategies to treat disorders of the neuromuscular system.

authors

• Dial, Athan G
• Ng, Sean Y
• Manta, Alexander
• Ljubicic, Vladimir

status

• published 

publication date

• May 2018

has subject area

• 1103 Clinical Sciences (FoR)
• 1114 Paediatrics and Reproductive Medicine (FoR)
• AMP-Activated Protein Kinases (MeSH)
• Animals (MeSH)
• Autophagy (MeSH)
• Endocrinology & Metabolism (Science Metrix)
• Humans (MeSH)
• Motor Neurons (MeSH)
• Muscle, Skeletal (MeSH)
• Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha (MeSH)
• Utrophin (MeSH)

published in

• Trends in Endocrinology and Metabolism  Journal

keywords

• AMP-Activated Protein Kinases
• Animals
• Autophagy
• Humans
• Motor Neurons
• Muscle, Skeletal
• Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
• Utrophin
• autophagy
• muscleblind-like 1
• peroxisome proliferator-activated receptor γ coactivator-1α
• survival of motor neuron
• utrophin

Digital Object Identifier (DOI)

• 10.1016/j.tem.2018.02.010

PubMed ID

• 29572064

start page

• 300

end page

• 312

volume

• 29

issue

• 5