Journal article
AMPK is mitochondrial medicine for neuromuscular disorders
Abstract
Duchenne muscular dystrophy (DMD), myotonic dystrophy type 1 (DM1), and spinal muscular atrophy (SMA) are the most prevalent neuromuscular disorders (NMDs) in children and adults. Central to a healthy neuromuscular system are the processes that govern mitochondrial turnover and dynamics, which are regulated by AMP-activated protein kinase (AMPK). Here, we survey mitochondrial stresses that are common between, as well as unique to, DMD, DM1, and …
Authors
Mikhail AI; Ng SY; Mattina SR; Ljubicic V
Journal
Trends in Molecular Medicine, Vol. 29, No. 7, pp. 512–529
Publisher
Elsevier
Publication Date
July 2023
DOI
10.1016/j.molmed.2023.03.008
ISSN
1471-4914