selected scholarly activity
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academic article
- Iron in airway macrophages and infective exacerbations of chronic obstructive pulmonary disease. Respiratory Research. 23:8. 2022
- Benralizumab's anti-eosinophil efficacy may be decreased by impaired NK cell activity. European Respiratory Journal European Respiratory Journal, Supplement. 59:2102210-2102210. 2022
- Impact of former smoking exposure on airway eosinophilic activation and autoimmunity in patients with severe asthma. European Respiratory Journal European Respiratory Journal, Supplement. 2102446-2102446. 2022
- Clinical relevance of sputum bronchial epithelial cells: A retrospective cross-sectional study. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 6:35-40. 2022
- EAACI position paper on the clinical use of the bronchial allergen challenge: Unmet needs and research priorities. Allergy: European Journal of Allergy and Clinical Immunology. 2022
- Standardized Cannabis Smoke Extract Induces Inflammation in Human Lung Fibroblasts. Frontiers in Pharmacology. 13:852029. 2022
- Role of Human Antigen R (HuR) in the Regulation of Pulmonary ACE2 Expression. Cells. 11:22-22. 2021
- Detecting immunoglobulins in processed sputa. Allergy: European Journal of Allergy and Clinical Immunology. 76:3798-3800. 2021
- HuR drives lung fibroblast differentiation but not metabolic reprogramming in response to TGF-β and hypoxia. Respiratory Research. 22:323. 2021
- Notch4, uncovering an immunomodulator in allergic asthma. Allergy: European Journal of Allergy and Clinical Immunology. 76:3852-3854. 2021
- Underestimation of airway luminal eosinophilia by quantitative sputum cytometry. Canadian Journal of Allergy and Clinical Immunology Allergy, Asthma and Clinical Immunology. 17:63. 2021
- Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections. Viruses. 13:2239-2239. 2021
- Pan-Canadian standards for severe asthma in electronic medical records. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 5:391-399. 2021
- Antibody Deficiency, Chronic Lung Disease, and Comorbid Conditions: A Case-Based Approach. Journal of Allergy and Clinical Immunology: In Practice. 9:3899-3908. 2021
- Defining a Severe Asthma Super-Responder: Findings from a Delphi Process. Journal of Allergy and Clinical Immunology: In Practice. 9:3997-4004. 2021
- Medical algorithms: Approach to adult asthma exacerbations. Allergy: European Journal of Allergy and Clinical Immunology. 76:3556-3559. 2021
- Risankizumab in Severe Asthma — A Phase 2a, Placebo-Controlled Trial. New England Journal of Medicine. 385:1669-1679. 2021
- Anti-interleukin-13 and anti-interleukin-4 agents versus placebo, anti-interleukin-5 or anti-immunoglobulin-E agents, for people with asthma. Cohrane Library Clinical Respiratory Journal. 2021:CD012929. 2021
- Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production. Journal of Cellular Physiology. 236:6836-6851. 2021
- Effect of anti‐IL‐5 biologics on weight and body mass index. Allergy: European Journal of Allergy and Clinical Immunology. 76:2913-2916. 2021
- Comprehensive Care Management in Conjunction with Sputum Cytometry-Guided Pharmacotherapy in a Post-Discharge Clinic for Patients with COPD. COPD: Journal of Chronic Obstructive Pulmonary Disease. 18:411-416. 2021
- Bronchial thermoplasty guided by hyperpolarised gas magnetic resonance imaging in adults with severe asthma: a 1-year pilot randomised trial. ERJ Open Research. 7:00268-2021. 2021
- Differential expression of sputum and serum autoantibodies in patients with chronic obstructive pulmonary disease. American Journal of Physiology - Lung Cellular and Molecular Physiology. 320:L1169-L1182. 2021
- Direct and indirect bronchoprovocation tests in dose‐response studies of inhaled corticosteroids: Past, present, and future directions. Allergy: European Journal of Allergy and Clinical Immunology. 76:1679-1692. 2021
- Neutrophilic asthma: misconception or misnomer?. The Lancet Respiratory Medicine. 9:441-443. 2021
- The role of eosinophils in sepsis and acute respiratory distress syndrome: a scoping review. Canadian Journal of Anaesthesia. 68:715-726. 2021
- Benralizumab for Prednisone-Dependent Eosinophilic Asthma Associated With Novel STAT3 Loss of Function Mutation. Chest. 159:e181-e184. 2021
- Monitoring eosinophils to guide therapy with biologics in asthma: does the compartment matter?. Allergy: European Journal of Allergy and Clinical Immunology. 76:1294-1297. 2021
- There is more to severe asthma associated with obesity than inflammation. Respirology. 26:288-289. 2021
- Aryl hydrocarbon receptor deficiency causes the development of chronic obstructive pulmonary disease through the integration of multiple pathogenic mechanisms. FASEB Journal. 35:e21376. 2021
- Dupilumab, severe asthma airway responses, and SARS‐CoV‐2 serology. Allergy: European Journal of Allergy and Clinical Immunology. 76:957-958. 2021
- Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19. American Journal of Physiology - Lung Cellular and Molecular Physiology. 320:L152-L157. 2021
- Asthma exacerbations on benralizumab are largely non‐eosinophilic. Allergy: European Journal of Allergy and Clinical Immunology. 76:375-379. 2021
- EAACI Biologicals Guidelines—Recommendations for severe asthma. Allergy: European Journal of Allergy and Clinical Immunology. 76:14-44. 2021
- Eosinophilia and Response to Bronchial Thermoplasty. American Journal of Respiratory and Critical Care Medicine. 203:148-148. 2021
- Multiple lung nodules, eosinophilia and severe asthma. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 1-4. 2021
- TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma. Clinical Epigenetics. 12:145. 2020
- Lessons of the month: A breathless severe asthmatic in the genomic era: Occam's razor or Hickam's dictum?. Clinical Medicine. 20:e264-e266. 2020
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Predictors of response to
anti‐IL‐5 biologics. Respirology. 25:1123-1125. 2020 - The effect of dupilumab on lung function parameters in patients with oral corticosteroid-dependent severe asthma. Respiratory Medicine: X. 2:100010-100010. 2020
- The Role of the TL1A/DR3 Axis in the Activation of Group 2 Innate Lymphoid Cells in Subjects with Eosinophilic Asthma. American Journal of Respiratory and Critical Care Medicine. 202:1105-1114. 2020
- Exacerbations of Severe Asthma While on Anti–IL-5 Biologics. Journal of Investigational Allergology and Clinical Immunology. 30:307-316. 2020
- Effects of Anti-T2 Biologic Treatment on Lung Ventilation Evaluated by MRI in Adults With Prednisone-Dependent Asthma. Chest. 158:1350-1360. 2020
- Suboptimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena. European Respiratory Journal European Respiratory Journal, Supplement. 56:2000117-2000117. 2020
- Exon 8 KIT mutation and pulmonary eosinophilia. Allergy: European Journal of Allergy and Clinical Immunology. 75:2094-2096. 2020
- Sputum and serum immunoglobulins in adult asthmatics with recurrent respiratory tract infections. Allergy: European Journal of Allergy and Clinical Immunology. 75:2105-2108. 2020
- Sputum quantitative cytometry in patients with interstitial lung disease and chronic cough. Respiratory Medicine. 170:106067-106067. 2020
- Sputum Inflammometry to Manage Chronic Obstructive Pulmonary Disease Exacerbations: Beyond Guidelines. Tuberculosis and Respiratory Diseases. 83:175-184. 2020
- Luminal Eosinophil Cell Death as a Biomarker for Loss of Asthma Control?. Chest. 157:1680-1681. 2020
- Efficacy and safety of treatment with biologicals (benralizumab, dupilumab and omalizumab) for severe allergic asthma: A systematic review for the EAACI Guidelines ‐ recommendations on the use of biologicals in severe asthma. Allergy: European Journal of Allergy and Clinical Immunology. 75:1043-1057. 2020
- Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines ‐ recommendations on the use of biologicals in severe asthma. Allergy: European Journal of Allergy and Clinical Immunology. 75:1023-1042. 2020
- Efficacy and safety of treatment with dupilumab for severe asthma: A systematic review of the EAACI guidelines—Recommendations on the use of biologicals in severe asthma. Allergy: European Journal of Allergy and Clinical Immunology. 75:1058-1068. 2020
- Reproducibility of Hyperpolarized 129Xe MRI Ventilation Defect Percent in Severe Asthma to Evaluate Clinical Trial Feasibility. Academic Radiology. 28:817-826. 2020
- Is Computed Tomography Airway Count Related to Asthma Severity and Airway Structure and Function?. American Journal of Respiratory and Critical Care Medicine. 201:923-933. 2020
- Efficacy of Intravenous Reslizumab in Oral Corticosteroid–Dependent Asthma. Journal of Allergy and Clinical Immunology: In Practice. 8:555-564. 2020
- Eosinophilic Asthma. Journal of Allergy and Clinical Immunology: In Practice. 8:465-473. 2020
- Mechanisms and therapeutic strategies for non‐T2 asthma. Allergy: European Journal of Allergy and Clinical Immunology. 75:311-325. 2020
- Review of monoclonal antibody therapies in asthma and allergic diseases - a new paradigm for precision medicine. Asian Pacific Journal of Allergy and Immunology. 38:78-90. 2020
- Inhaled Corticosteroids and Adult Asthma. American Journal of Respiratory and Critical Care Medicine. 200:1556-1557. 2019
- Omalizumab in patients with severe asthma and persistent sputum eosinophilia. Canadian Journal of Allergy and Clinical Immunology Allergy, Asthma and Clinical Immunology. 15:21. 2019
- Normalisation of MRI ventilation heterogeneity in severe asthma by dupilumab. Thorax. 74:1087-1088. 2019
- Severe asthma: Entering an era of new concepts and emerging therapies: Highlights of the 4th international severe asthma forum, Madrid, 2018. Allergy: European Journal of Allergy and Clinical Immunology. 74:2244-2248. 2019
- Response. Chest. 156:808-809. 2019
- Reply to Yilmaz: Selection of Biologics for Type 2–High Asthma. American Journal of Respiratory and Critical Care Medicine. 200:791-792. 2019
- Optimizing sputum cell counts prior to bronchial thermoplasty: A preliminary report. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 3:143-147. 2019
- Effect of sex on group 2 innate lymphoid cells in the airways of mild and severe asthmatics. Allergy: European Journal of Allergy and Clinical Immunology. 74:1397-1400. 2019
- CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma. Chest. 155:1178-1189. 2019
- Clinical biomarkers and noninvasive assessment of severe asthma. ERS Monograph. 2019:93-112. 2019
- Rapid quantification of sputum eosinophil peroxidase on a lateral flow test strip. Allergy: European Journal of Allergy and Clinical Immunology. 74:1176-1178. 2019
- Eosinophil-derived IL-13 promotes emphysema. European Respiratory Journal European Respiratory Journal, Supplement. 53:1801291-1801291. 2019
- Much ado about Biologicals: Highlights of the Master Class on Biologicals, Prague, 2018. Allergy: European Journal of Allergy and Clinical Immunology. 74:837-840. 2019
- 275. FACTORS ASSOCIATED WITH DISEASE PROGRESSION IN PATIENTS WITH MYELOPEROXIDASE-ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-RELATED PULMONARY FIBROSIS. Rheumatology. 58. 2019
- Serum cytokine and chemokine levels in patients with eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or eosinophilic asthma.. Clinical and Experimental Rheumatology. 37 Suppl 117:40-44. 2019
- Role of Biologics in Asthma. American Journal of Respiratory and Critical Care Medicine. 199:433-445. 2019
- The interleukin-13 paradox in asthma: effective biology, ineffective biologicals. European Respiratory Journal European Respiratory Journal, Supplement. 53:1802250-1802250. 2019
- Sputum Antineutrophil Cytoplasmic Antibodies in Serum Antineutrophil Cytoplasmic Antibody–Negative Eosinophilic Granulomatosis with Polyangiitis. American Journal of Respiratory and Critical Care Medicine. 199:158-170. 2019
- Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial. The Lancet Respiratory Medicine. 7:46-59. 2019
- Serum cytokine and chemokine levels in patients with eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or eosinophilic asthma. Clinical and Experimental Rheumatology. 37:S40-S44. 2019
- Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD. Clinical Epigenetics. 10:32. 2018
- Loss of bronchoprotection to Salbutamol during sputum induction with hypertonic saline: implications for asthma therapy. Canadian Journal of Allergy and Clinical Immunology Allergy, Asthma and Clinical Immunology. 14:26. 2018
- Modulation of human airway smooth muscle biology by human adipocytes. Respiratory Research. 19:33. 2018
- Airway Eosinophilopoietic and Autoimmune Mechanisms of Eosinophilia in Severe Asthma. Immunology and Allergy Clinics of North America Clinics in Immunology and Allergy. 38:639-654. 2018
- Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma. New England Journal of Medicine. 378:2475-2485. 2018
- Free-breathing Pulmonary MR Imaging to Quantify Regional Ventilation. Radiology. 287:693-704. 2018
- Benralizumab attenuates airway eosinophilia in prednisone-dependent asthma. Journal of Allergy and Clinical Immunology. 141:1529-1532.e8. 2018
- Sputum Eosinophilia and Magnetic Resonance Imaging Ventilation Heterogeneity in Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 197:876-884. 2018
- Sputum autoantibodies in patients with severe eosinophilic asthma. Journal of Allergy and Clinical Immunology. 141:1269-1279. 2018
- Endogenous peroxidases in sputum interfere with horse-radish peroxidase-based ELISAs. Journal of Immunological Methods. 454:76-79. 2018
- Airway Inflammation and Inflammatory Biomarkers. Seminars in Respiratory and Critical Care Medicine. 39:056-063. 2018
- Anti-interleukin-13 and anti-interleukin-4 agents versus placebo, anti-interleukin-5 or anti-immunoglobulin-E agents, for children and adults with asthma. Cohrane Library Clinical Respiratory Journal. 2018. 2018
- This is what asthma looks like: Review of new and emerging functional imaging methods and results. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 2:27-40. 2018
- Autoimmune Responses in Severe Asthma. Allergy, Asthma and Immunology Research. 10:428-428. 2018
- Human Bronchial Epithelial Cell–derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil Differentiation. American Journal of Respiratory Cell and Molecular Biology. 58:99-106. 2018
- Sputum plug selection under inverted microscopy improves microbial identification during exacerbations of airway diseases. Respiratory Medicine. 134:92-94. 2018
- Weight-adjusted Intravenous Reslizumab in Severe Asthma with Inadequate Response to Fixed-Dose Subcutaneous Mepolizumab. American Journal of Respiratory and Critical Care Medicine. 197:38-46. 2018
- Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy. Canadian Journal of Allergy and Clinical Immunology Allergy, Asthma and Clinical Immunology. 13:2. 2017
- Hemosiderin in sputum macrophages may predict infective exacerbations of chronic obstructive pulmonary disease: a retrospective observational study. BMC Pulmonary Medicine. 17:60. 2017
- Regulation of human airway smooth muscle cell migration and relevance to asthma. Respiratory Research. 18:156. 2017
- Sputum cell counts to manage prednisone-dependent asthma: effects on FEV1 and eosinophilic exacerbations. Canadian Journal of Allergy and Clinical Immunology Allergy, Asthma and Clinical Immunology. 13:17. 2017
- Free-breathing Functional Pulmonary MRI. Academic Radiology. 24:1268-1276. 2017
- Improved recovery of functionally active eosinophils and neutrophils using novel immunomagnetic technology. Journal of Immunological Methods. 449:44-55. 2017
- Glucocorticoid Sparing of Benralizumab in Asthma. New England Journal of Medicine. 377:1204-1205. 2017
- Oral Glucocorticoid–Sparing Effect of Benralizumab in Severe Asthma. New England Journal of Medicine. 376:2448-2458. 2017
- Recalcitrant steroid-resistant EGPA with multisystem involvement. Case Reports in Internal Medicine Case Reports in Internal Medicine. 4:12-12. 2017
- Airway Hyperresponsiveness in Asthma: Measurement and Clinical Relevance. Journal of Allergy and Clinical Immunology: In Practice. 5:649-659.e2. 2017
- The use of cellular and molecular biomarkers to manage COPD exacerbations. Expert Review of Respiratory Medicine. 11:1-9. 2017
- Challenges of managing asthma in an elderly population. Polskie Archiwum Medycyny Wewnetrznej. 127:291-293. 2017
- A pilot randomised clinical trial of mepolizumab in COPD with eosinophilic bronchitis. European Respiratory Journal European Respiratory Journal, Supplement. 49:1602486-1602486. 2017
- Changing Paradigms in the Treatment of Severe Asthma: The Role of Biologic Therapies. Journal of Allergy and Clinical Immunology: In Practice. 5:S1-S14. 2017
- WS1_1 Sputum Anti-neutrophil Cytoplasmic Antibodies (ANCA) in Eosinophilic Granulamatosis and Polyangiitis (eGPA). Rheumatology. 56:iii17-iii19. 2017
- Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clinical and Experimental Allergy. 47:161-175. 2017
- Asthma Endotypes and an Overview of Targeted Therapy for Asthma. Frontiers in Medicine. 4:158. 2017
- Glucocortiosteroid subsensitivity and asthma severity. Current Opinion in Pulmonary Medicine. 23:78-88. 2017
- Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability. PLoS ONE. 12:e0180881-e0180881. 2017
- Development of a functional point-of-need diagnostic for myeloperoxidase detection to identify neutrophilic bronchitis. The Analyst. 141:6438-6443. 2016
- Benralizumab, an anti-interleukin-5 receptor a monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial. The Lancet. 388:2128-2141. 2016
- Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial. The Lancet. 388:2128-2141. 2016
- Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial. The Lancet Respiratory Medicine. 4:797-806. 2016
- Measuring Eosinophils to Make Treatment Decisions in Asthma. Chest. 150:485-487. 2016
- Eosinophilic Endotype of Asthma. Immunology and Allergy Clinics of North America Clinics in Immunology and Allergy. 36:559-568. 2016
- Is ventilation heterogeneity related to asthma control?. European Respiratory Journal European Respiratory Journal, Supplement. 48:370-379. 2016
- A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease. Mucosal Immunology. 9:859-872. 2016
- Human bronchial and parenchymal fibroblasts display differences in basal inflammatory phenotype and response to IL-17A. Clinical and Experimental Allergy. 46:945-956. 2016
- Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma. Clinical and Experimental Allergy. 46:793-802. 2016
- Histone deacetylase activity and recurrent bacterial bronchitis in severe eosinophilic asthma. Allergy: European Journal of Allergy and Clinical Immunology. 71:571-575. 2016
- Nasal and pharyngeal eosinophil peroxidase levels in adults with poorly controlled asthma correlate with sputum eosinophilia. Allergy: European Journal of Allergy and Clinical Immunology. 71:567-570. 2016
- Dysregulation of Vascular Endothelial Progenitor Cells Lung-Homing in Subjects with COPD. Canadian Respiratory Journal. 2016:1-10. 2016
- Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia. Journal of Allergy and Clinical Immunology. 137:75-86.e8. 2016
- Decreased expression of the NF-κB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression. Respiratory Research. 16:54. 2015
- Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients. Respiratory Research. 16:72. 2015
- Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M. Respiratory Research. 16:14. 2015
- The aryl hydrocarbon receptor suppresses cigarette-smoke-induced oxidative stress in association with dioxin response element (DRE)-independent regulation of sulfiredoxin 1. Free Radical Biology and Medicine. 89:342-357. 2015
- Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma. Canadian Journal of Allergy and Clinical Immunology Allergy, Asthma and Clinical Immunology. 11:14. 2015
- Blood or sputum eosinophils to guide asthma therapy?. The Lancet Respiratory Medicine. 3:824-825. 2015
- Metabolomic profiling of asthma and chronic obstructive pulmonary disease: A pilot study differentiating diseases. Journal of Allergy and Clinical Immunology. 136:571-580.e3. 2015
- MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity. Journal of Allergy and Clinical Immunology. 136:462-473. 2015
- A perspective on point-of-care tests to detect eosinophilic bronchitis. Journal of Asthma The Journal of asthma research. 52:254-261. 2015
- Efficacy and safety of reslizumab in patients with moderate to severe eosinophilic asthma. Expert Review of Respiratory Medicine. 9:135-142. 2015
- The Effect of Omega-3 Fatty Acids on Bronchial Hyperresponsiveness, Sputum Eosinophilia, and Mast Cell Mediators in Asthma. Chest. 147:397-405. 2015
- A Multidimensional Approach to the Management of Severe Asthma: Inflammometry, Molecular Microbiology and Bronchial Thermoplasty. Canadian Respiratory Journal. 22:221-224. 2015
- Changing Pattern of Sputum Cell Counts During Successive Exacerbations of Chronic Obstructive Pulmonary Disease.. COPD: Journal of Chronic Obstructive Pulmonary Disease. 12:628-635. 2015
- Therapeutic implications of ‘neutrophilic asthma’. Current Opinion in Pulmonary Medicine. 21:33-38. 2015
- Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure. Respiratory Research. 15:49. 2014
- Upregulation of IL-17A/F from human lung tissue explants with cigarette smoke exposure: implications for COPD. Respiratory Research. 15:145. 2014
- MicroRNA-155 Is Required for Clearance of Streptococcus pneumoniae from the Nasopharynx. Infection and Immunity. 82:4824-4833. 2014
- Anti–Interleukin-5 Monoclonal Antibody to Treat Severe Eosinophilic Asthma. New England Journal of Medicine. 371:1249-1251. 2014
- Relationship between Sputum Eosinophilia and Sinus Disease in Patients with Eosinophilic Bronchitis. American Journal of Rhinology American Journal of Rhinology and Allergy. 28:378-382. 2014
- The effects of an epithelial barrier protective cationic aerosol on allergen-induced airway inflammation in asthma: a randomized, placebo-controlled clinical trial. Clinical and Experimental Allergy. 44:1200-1203. 2014
- Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial. Clinical and Experimental Allergy. 44:508-516. 2014
- Omalizumab for asthma in adults and children. Cohrane Library Clinical Respiratory Journal. 2014:CD003559. 2014
- A halotyrosine antibody that detects increased protein modifications in asthma patients. Journal of Immunological Methods. 403:17-25. 2014
- Anti-IL5 therapy for asthma and beyond. World Allergy Organization Journal. 7:32-32. 2014
- Monoclonal antibodies for the treatment of refractory asthma. Current Opinion in Pulmonary Medicine. 20:87-94. 2014
- The evolution of sputum cytometry to assess bronchitis. (vol 20, pg 417, 2013). Canadian Respiratory Journal. 21:51-51. 2014
- Targeted therapy of bronchitis in obstructive airway diseases. Pharmacology and Therapeutics Pharmacology and Therapeutics Part B General and Systematic Pharmacology Pharmacology and Therapeutics Part C Clinical Pharmacology and Therapeutics Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and. 140:213-222. 2013
- The effects of rituximab on serum IgE and BAFF. Canadian Journal of Allergy and Clinical Immunology Allergy, Asthma and Clinical Immunology. 9:39. 2013
- Cytokine responses of peripheral blood mononuclear cells to allergen do not identify asthma or asthma phenotypes. Clinical and Experimental Allergy. 43:1226-1235. 2013
- Sample sizes for clinical trials using sputum eosinophils as a primary outcome. European Respiratory Journal European Respiratory Journal, Supplement. 42:1003-1011. 2013
- Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia. Allergy: European Journal of Allergy and Clinical Immunology. 68:n/a-n/a. 2013
- Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. Molecular Nutrition and Food Research Die Nahrung. 57:1378-1389. 2013
- Associations between airway hyperresponsiveness, obesity and lipoproteins in a longitudinal cohort. Cohrane Library Clinical Respiratory Journal. 7:268-275. 2013
- What is an “eosinophilic phenotype” of asthma?. Journal of Allergy and Clinical Immunology. 132:81-83. 2013
- Dose-dependent anti-inflammatory effect of inhaled mometasone furoate/formoterol in subjects with asthma. Respiratory Medicine. 107:656-664. 2013
- When are biomarkers useful in the management of airway diseases?. Polskie Archiwum Medycyny Wewnetrznej. 123:183-188. 2013
- Asthma Associated With Incontinentia Pigmenti and Fanconi Anemia. Chest. 143:856-858. 2013
- PPAR ligands decrease human airway smooth muscle cell migration and extracellular matrix synthesis. European Respiratory Journal European Respiratory Journal, Supplement. 41:425-432. 2013
- TNFα antagonists for acute exacerbations of COPD: a randomised double-blind controlled trial. Thorax. 68:142-148. 2013
- Aryl Hydrocarbon Receptor-Dependent Retention of Nuclear HuR Suppresses Cigarette Smoke-Induced Cyclooxygenase-2 Expression Independent of DNA-Binding. PLoS ONE. 8:e74953-e74953. 2013
- Quantitative Sputum Cell Counts to Monitor Bronchitis: A Qualitative Study of Physician and Patient Perspectives. Canadian Respiratory Journal. 20:47-51. 2013
- Sputum Hyaluronan and Versican in Severe Eosinophilic Asthma. International Archives of Allergy and Immunology. 161:65-73. 2013
- The Evolution of Sputum Cytometry to Assess Bronchitis. Canadian Respiratory Journal. 20:415-416. 2013
- Update on Clinical Inflammometry for the Management of Airway Diseases. Canadian Respiratory Journal. 20:117-120. 2013
- Addition of intravenous aminophylline to inhaled beta2-agonists in adults with acute asthma. Cohrane Library Clinical Respiratory Journal. 12:CD002742. 2012
- Local and systemic immunological parameters associated with remission of asthma symptoms in children. Canadian Journal of Allergy and Clinical Immunology Allergy, Asthma and Clinical Immunology. 8:16. 2012
- A sensitive high throughput ELISA for human eosinophil peroxidase: A specific assay to quantify eosinophil degranulation from patient-derived sources. Journal of Immunological Methods. 384:10-20. 2012
- How to Diagnose and Phenotype Asthma. Clinics in Chest Medicine. 33:445-457. 2012
- Serum periostin as a marker of TH2-dependent eosinophilic airway inflammation. Journal of Allergy and Clinical Immunology. 130:655-656. 2012
- Sputum cell counts and methacholine hyperresponsiveness as asthma outcomes. Journal of Allergy and Clinical Immunology. 130:823-823. 2012
- Methacholine test and the diagnosis of asthma. Journal of Allergy and Clinical Immunology. 130:556-556. 2012
- Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial. Clinical and Experimental Allergy. 42:1097-1103. 2012
- Equivalence Considerations for Orally Inhaled Products for Local Action—ISAM/IPAC-RS European Workshop Report. Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung Journal of Aerosol Medicine and Pulmonary Drug Delivery. 25:117-139. 2012
- Proximity to major roadways is a risk factor for airway hyper-responsiveness in adults (vol 2, pg 89, 2012). Canadian Respiratory Journal. 19:186-186. 2012
- Interleukin-4 and interleukin-13 prime migrational responses of haemopoietic progenitor cells to stromal cell-derived factor-1α. Clinical and Experimental Allergy. 42:255-264. 2012
- Cystic Fibrosis Transmembrane Conductance Regulator Gene Abnormalities in Patients with Asthma and Recurrent Neutrophilic Bronchitis. Canadian Respiratory Journal. 19:46-48. 2012
- Proximity to Major Roadways is a Risk Factor for Airway Hyper-Responsiveness in Adults. Canadian Respiratory Journal. 19:89-95. 2012
- Proximity to major roadways is a risk factor for airway hyper-responsiveness in adults (Canadian Respiratory Journal (2012) 2, (89-96)). Canadian Respiratory Journal. 19:186. 2012
- In memoriam: Frederick E Hargreave (1938-2011). Thorax. 66:1101-1102. 2011
- The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma. Canadian Journal of Allergy and Clinical Immunology Allergy, Asthma and Clinical Immunology. 7:4. 2011
- Reslizumab for Poorly Controlled, Eosinophilic Asthma. American Journal of Respiratory and Critical Care Medicine. 184:1125-1132. 2011
- Lipid and smoker’s inclusions in sputum macrophages in patients with airway diseases. Respiratory Medicine. 105:1691-1695. 2011
- Serum Procalcitonin and Infective Exacerbations of Asthma. Chest. 140:1389-1390. 2011
- Expiratory flows and airway inflammation in elderly asthmatic patients. Respiratory Medicine. 105:1284-1289. 2011
- Point: Is Measuring Sputum Eosinophils Useful in the Management of Severe Asthma? Yes. Chest. 139:1270-1273. 2011
- Rebuttal From Drs Hargreave and Nair. Chest. 139:1275-1277. 2011
- Nontubercular Mycobacterial Pulmonary Infection in Severe Asthma. Chest. 139:721-721. 2011
- Reply. Journal of Allergy and Clinical Immunology. 127:834-834. 2011
- Association between Proximity to Major Roads and Sputum Cell Counts. Canadian Respiratory Journal. 18:13-18. 2011
- Cholinergics, airway eosinophils and asthma exacerbation in the elderly.. The Indian journal of chest diseases & allied sciences. 53:59-61. 2011
- Early interventions with inhaled corticosteroids in asthma: benefits and risks. Current Opinion in Pulmonary Medicine. 17:12-15. 2011
- Effects of a Short Course of Inhaled Corticosteroids in Noneosinophilic Asthmatic Subjects. Canadian Respiratory Journal. 18:278-282. 2011
- Frederick E Hargreave. Canadian Respiratory Journal. 18:193-193. 2011
- Heterogeneity of Bronchitis in Airway Diseases in Tertiary Care Clinical Practice. Canadian Respiratory Journal. 18:144-148. 2011
- Persistent Sputum Cellularity and Neutrophils May Predict Bronchiectasis. Canadian Respiratory Journal. 18:221-224. 2011
- Reproducibility, Validity, and Responsiveness of Cell Counts in Blown Nasal Secretions. Allergy & Rhinology Allergy and Rhinology. 2:ar.2011.2.0006-ar.2011.2.0006. 2011
- Paranasal sinus disease and sputum eosinophilia in prednisone-dependent asthma.. Journal of Otolaryngology - Head and Neck Surgery. 39:703-709. 2010
- Atmospheric remote sensing to detect effects of temperature inversions on sputum cell counts in airway diseases. Environmental Research. 110:624-632. 2010
- Measuring Bronchitis in Airway Diseases: Clinical Implementation and Application. Chest. 138:38S-43S. 2010
- Nitric oxide in exhaled breath is poorly correlated to sputum eosinophils in patients with prednisone-dependent asthma. Journal of Allergy and Clinical Immunology. 126:404-406. 2010
- Variability of sputum inflammatory cells in asthmatic patients receiving corticosteroid therapy: A prospective study using multiple samples. Journal of Allergy and Clinical Immunology. 125:1161-1163.e4. 2010
- Airway Responsiveness to Indirect Challenges in COPD. COPD: Journal of Chronic Obstructive Pulmonary Disease. 7:133-140. 2010
- Monitoring sputum eosinophils in mucosal inflammation and remodelling: a pilot study. European Respiratory Journal European Respiratory Journal, Supplement. 35:48-53. 2010
- Diffuse idiopathic pulmonary neuroendocrine hyperplasia, chronic eosinophilic pneumonia, and asthma. European Respiratory Journal European Respiratory Journal, Supplement. 34:1489-1492. 2009
- Clinical equivalence testing of inhaled bronchodilators. Polskie Archiwum Medycyny Wewnetrznej. 119:731-735. 2009
- The definition and diagnosis of Asthma. Clinical and Experimental Allergy. 39:1652-1658. 2009
- From the authors. American Journal of Respiratory and Critical Care Medicine. 180:581-582. 2009
- Potential Risks of Using LABAs with ICS Therapy. American Journal of Respiratory and Critical Care Medicine. 180:581-582. 2009
- Antiinflammatory Effects of Long-Acting β 2 -Agonists in Patients With Asthma. Chest. 136:145-154. 2009
- Human airway smooth muscle promotes eosinophil differentiation. Clinical and Experimental Allergy. 39:1009-1017. 2009
- Anti-Interleukin-5 Therapy and Severe Asthma REPLY. New England Journal of Medicine. 360:2577-2577. 2009
- Dr. Nair and colleagues reply. New England Journal of Medicine. 360:2577. 2009
- Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia. New England Journal of Medicine. 360:985-993. 2009
- The Safety of Long-Acting β-Agonists among Patients with Asthma Using Inhaled Corticosteroids. American Journal of Respiratory and Critical Care Medicine. 178:1009-1016. 2008
- LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1. American Journal of Physiology - Lung Cellular and Molecular Physiology. 295:L949-L957. 2008
- The safety of formoterol among patients with asthma using inhaled corticosteroids. Systematic review and meta‑analysis. Polskie Archiwum Medycyny Wewnetrznej. 118:627-635. 2008
- The Effects of Leptin on Airway Smooth Muscle Responses. American Journal of Respiratory Cell and Molecular Biology. 39:475-481. 2008
- A cumulative dose study of levalbuterol and racemic albuterol administered by hydrofluoroalkane-134a metered-dose inhaler in asthmatic subjects. Journal of Allergy and Clinical Immunology. 122:544-549. 2008
- Asthma Management by Monitoring Sputum Neutrophil Count. Chest. 134:628-630. 2008
- Does early intervention with inhaled corticosteroids alter the natural history of mild persistent asthma?. Polskie Archiwum Medycyny Wewnetrznej. 118:441-444. 2008
- Cost Analysis of Monitoring Asthma Treatment using Sputum Cell Counts. Canadian Respiratory Journal. 15:370-374. 2008
- Safety and Efficacy of Bronchial Thermoplasty in Symptomatic, Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 176:1185-1191. 2007
- Changing pattern of sputum cell counts during successive exacerbations of airway disease. Respiratory Medicine. 101:2217-2220. 2007
- Modulation of Human Airway Smooth Muscle Migration by Lipid Mediators and Th-2 Cytokines. American Journal of Respiratory Cell and Molecular Biology. 37:240-247. 2007
- Effect of obesity on airway inflammation: a cross-sectional analysis of body mass index and sputum cell counts. Clinical and Experimental Allergy. 37:1049-1054. 2007
- Asthma Control during the Year after Bronchial Thermoplasty. New England Journal of Medicine. 356:1327-1337. 2007
- Combining LABA and ICS in patients with severe COPD. Polskie Archiwum Medycyny Wewnetrznej. 117:6-8. 2007
- Sputum Neutrophilia Can Mask Eosinophilic Bronchitis During Exacerbations. Canadian Respiratory Journal. 14:281-284. 2007
- Ventilation and Perfusion Lung Scintigraphy of Allergen-Induced Airway Responses in Atopic Asthmatic Subjects. Canadian Respiratory Journal. 14:285-291. 2007
- Asthma as a disease concept. The Lancet. 368:1415-1416. 2006
- Reply. Journal of Allergy and Clinical Immunology. 118:970-971. 2006
- Asthma, COPD and bronchitis are just components of airway disease. European Respiratory Journal European Respiratory Journal, Supplement. 28:264-267. 2006
- Pharmacological management of mild or moderate persistent asthma. The Lancet. 368:794-803. 2006
- Effects of intranasal fluticasone and salmeterol on allergen-induced nasal responses. Allergy: European Journal of Allergy and Clinical Immunology. 61:731-736. 2006
- Problems with using exhaled nitric oxide to guide asthma treatment. Journal of Allergy and Clinical Immunology. 117:1511-1511. 2006
- Eosinophilic bronchitis in asthma: A model for establishing dose-response and relative potency of inhaled corticosteroids. Journal of Allergy and Clinical Immunology. 117:989-994. 2006
- Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. European Respiratory Journal European Respiratory Journal, Supplement. 27:483-494. 2006
- Treatment Strategy for Asthma. Chest. 129:221-223. 2006
- Altered Respiratory Physiology in Obesity. Canadian Respiratory Journal. 13:203-210. 2006
- Predictors of Loss of Asthma Control Induced by Corticosteroid Withdrawal. Canadian Respiratory Journal. 13:129-133. 2006
- Efficacy of fluticasone on cough. European Respiratory Journal European Respiratory Journal, Supplement. 26:181-181. 2005
- Extracellular matrix regulates human airway smooth muscle cell migration. European Respiratory Journal European Respiratory Journal, Supplement. 24:545-551. 2004
- Role for cysteinyl leukotrienes in allergen-induced change in circulating dendritic cell number in asthma. Journal of Allergy and Clinical Immunology. 114:73-79. 2004
- The Effect of Pranlukast on Allergen-induced Bone Marrow Eosinophilopoiesis in Subjects with Asthma. American Journal of Respiratory and Critical Care Medicine. 169:915-920. 2004
- Leukotriene receptor antagonists for allergic rhinitis: a systematic review and meta-analysis. American Journal of Medicine. 116:338-344. 2004
- Satellite observations of the regional aerosol distribution and transport over the Arabian Sea, Bay of Bengal and Indian Ocean. Indian Journal of Marine Sciences Indian Journal of Geo-Marine Sciences. 33:11-29. 2004
- Continental influence on the spatial distribution of particulate loading over the Indian Ocean during winter season. Journal of Atmospheric and Solar-Terrestrial Physics Journal of Atmospheric and Terrestrial Physics. 66:27-38. 2004
- Rayleigh lidar observations of quasi-sinusoidal waves in the tropical middle atmosphere. Journal of Geophysical Research. 108:n/a-n/a. 2003
- Financial Disclosure of Reviewers. American Journal of Respiratory and Critical Care Medicine. 168:1010-1010. 2003
- Persistent troublesome cough. American Journal of Respiratory and Critical Care Medicine. 167:1151-1151. 2003
- Clinical Models to Compare the Safety and Efficacy of Inhaled Corticosteroids in Patients with Asthma. Canadian Respiratory Journal. 10:27-34. 2003
- Inhaled Corticosteroids for Asthma: Common Clinical Quandaries. Journal of Asthma The Journal of asthma research. 40:107-118. 2003
- Cysteinyl Leukotrienes Promote Human Airway Smooth Muscle Migration. American Journal of Respiratory and Critical Care Medicine. 166:738-742. 2002
- Clinical applications of assessment of airway inflammation using induced sputum. European Respiratory Journal European Respiratory Journal, Supplement. 20:40S-43s. 2002
- The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. Journal of Allergy and Clinical Immunology. 110:96-101. 2002
- The use of induced sputum in clinical trials. European Respiratory Journal European Respiratory Journal, Supplement. 20:47S-50s. 2002
- Reply. Journal of Allergy and Clinical Immunology. 109:575-576. 2002
- Airway Hyperresponsiveness and Calcium Handling by Smooth Muscle. Chest. 121:621-624. 2002
- Inhaled Leukotriene E4, But Not Leukotriene D4, Increased Airway Inflammatory Cells in Subjects with Atopic Asthma. American Journal of Respiratory and Critical Care Medicine. 164:1495-1500. 2001
- The trials and tribulations of IL-5, eosinophils, and allergic asthma. Journal of Allergy and Clinical Immunology. 108:503-508. 2001
- The use of sputum cell counts to evaluate asthma medications. British Journal of Clinical Pharmacology. 52:121-128. 2001
- Repeatability and validity of cell and fluid-phase measurements in nasal fluid: a comparison of two methods of nasal lavage. Clinical and Experimental Allergy. 31:1111-1115. 2001
- Coronary and laryngeal spasm provoked by methacholine inhalation. Journal of Allergy and Clinical Immunology. 107:392-393. 2001
- Sputum Cell Counts and Exhaled Nitric Oxide in Patients with Gastroesophageal Reflux, and Cough or Asthma. Canadian Respiratory Journal. 8:239-244. 2001
- Lipid-laden macrophages in induced sputum are a marker of oropharyngeal reflux and possible gastric aspiration. European Respiratory Journal European Respiratory Journal, Supplement. 16:1119-1122. 2000
- Reproducibility, validity, and responsiveness of a disease-specific symptom questionnaire for gastroesophageal reflux disease. Diseases of the Esophagus. 13:265-270. 2000
- "Induced sputum cell counts: their usefulness in clinical practice" (vol 16, pg 150, 2000). European Respiratory Journal European Respiratory Journal, Supplement. 16:1029-1029. 2000
- A comparison of exhaled nitric oxide and induced sputum as markers of airway inflammation. Journal of Allergy and Clinical Immunology. 106:638-644. 2000
- Induced sputum cell counts: their usefulness in clinical practice. European Respiratory Journal European Respiratory Journal, Supplement. 16:150-158. 2000
- Clinical judgement of airway inflammation versus sputum cell counts in patients with asthma. European Respiratory Journal European Respiratory Journal, Supplement. 15:486-490. 2000
- Induced Sputum Cell Counts in Healthy Adults. American Journal of Respiratory and Critical Care Medicine. 161:475-478. 2000
- Induced sputum cell counts in healthy adults. American Journal of Respiratory and Critical Care Medicine. 161:475-478. 2000
- Addition of intravenous aminophylline to beta2-agonists in adults with acute asthma. Cochrane Database of Systematic Reviews. CD002742. 2000
- Protective Effects of Fluticasone on Allergen-Induced Airway Responses and Sputum Inflammatory Markers. Canadian Respiratory Journal. 7:313-319. 2000
- Concepts of establishing clinical bioequivalence of chlorofluorocarbon and hydrofluoroalkane β-agonists☆☆☆★. Journal of Allergy and Clinical Immunology. 104:s243-s245. 1999
- Sputum eosinophil count to assess compliance with corticosteroid therapy in asthma. Journal of Allergy and Clinical Immunology. 104:502-503. 1999
- Sputum eosinophil count to assess compliance with corticosteroid therapy in asthma☆☆☆★★★. Journal of Allergy and Clinical Immunology. 104:502-503. 1999
- Asthma exacerbations. The Lancet. 353:1443-1443. 1999
- Acute effects of nebulised epoprostenol in pulmonary hypertension due to systemic sclerosis. Respiratory Medicine. 93:75-78. 1999
- Nonasthmatic Chronic Cough: No Effect of Treatment with an Inhaled Corticosteriod in Patients without Sputum Eosinophilia. Canadian Respiratory Journal. 6:323-330. 1999
- Sputum Eosinophilia Predicts Benefit from Prednisone in Smokers with Chronic Obstructive Bronchitis. American Journal of Respiratory and Critical Care Medicine. 158:1511-1517. 1998
- Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis. American Journal of Respiratory and Critical Care Medicine. 158:1511-1517. 1998
- COMPARISON OF TWO METHODS OF PROCESSING INDUCED SPUTUM: SELECTED VERSUS ENTIRE SPUTUM. American Journal of Respiratory and Critical Care Medicine. 158:680-682. 1998
- Serial sputum cell counts in the management of chronic airflow limitation. European Respiratory Journal European Respiratory Journal, Supplement. 11:1405-1408. 1998
- Concurrent Catamenial Hemothorax and Hemopneumothorax. Chest. 103:646-648. 1993
- CFTR heterozygosity in severe airways disease with recurrent airway infections: a retrospective review
- Underestimation of Luminal Eosinophilia by Quantitative Sputum Cytometry
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chapter
- Practical considerations in the management of eosinophilic asthma 2019
- The human eosinophil. 505-580. 2018
- Eosinophils in Human Disease. 431-536. 2013
- Asthma diagnosis 2011
- Management of Severe Asthma 2011
- Assessment of asthma control: markers of inflammation 2001
- Airway Disease, inflammometry, and individualized treatment
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conference paper
- Effects of Traffic-Related Air Pollution on Exercise Endurance, Dyspnea, and Cardiorespiratory Responses in Health and COPD. Chest. 662-675. 2022
- Association Between CT Mucus Plugging and Airway Wall Thickness in COPD and Asthma. American Journal of Respiratory and Critical Care Medicine. 2021
- Bronchial Thermoplasty Guided by Inhaled Hyperpolarized Gas Magnetic Resonance Imaging in Severe Asthma: A One-Year Pilot Randomized Trial. American Journal of Respiratory and Critical Care Medicine. 2021
- Clinical Indices of Autoimmunity Do Not Predict Sputum Autoantibodies in Patients with Severe Eosinophilic Asthma: A Prospective Study. American Journal of Respiratory and Critical Care Medicine. 2021
- Inspiratory and Expiratory Respiratory System Resistance in Severe Asthma Pre- and Post-Bronchodilator. American Journal of Respiratory and Critical Care Medicine. 2021
- Intact Cell Differential Count on a Single Occasion Underestimates Sputum Eosinophilic Activity. American Journal of Respiratory and Critical Care Medicine. 2021
- The Regulation of Pulmonary ACE2 by Human Antigen R (HuR). American Journal of Respiratory and Critical Care Medicine. 2021
- Effect of Dupilumab Treatment on Blood Eosinophil Levels in Patients With Asthma, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Eosinophilic Esophagitis (EoE), or Atopic Dermatitis (AD). Journal of Allergy and Clinical Immunology. AB140-AB140. 2021
- Airway autoimmunity and response to a 14-day course of oral corticosteroids in patients with severe eosinophilic asthma. European Respiratory Journal European Respiratory Journal, Supplement. 2020
- CD6-ALCAM Pathway is Elevated in Patients with Severe Asthma. European Respiratory Journal European Respiratory Journal, Supplement. 2020
- Characterisation of the neutrophilic asthma phenotype over time. European Respiratory Journal European Respiratory Journal, Supplement. 2020
- Differential treatment response to mepolizumab in severe eosinophilic asthma with nasal polyps. European Respiratory Journal European Respiratory Journal, Supplement. 2020
- Suboptimal response to benralizumab is not associated with inadequate eosinophil suppression. Allergy: European Journal of Allergy and Clinical Immunology. 405-406. 2020
- Differential Methylation of TWIST1 Is a Biomarker of Airway Versus Parenchymal Fibroblasts Within the Lung: Relevance to Asthma Pathogenesis. American Journal of Respiratory and Critical Care Medicine. 2020
- TL1A/DR3 Axis Promotes Group 2 Innate Lymphocyte Activation in Eosinophilic Asthmatics. American Journal of Respiratory and Critical Care Medicine. 2020
- The Role of Excess Airway Macrophage Iron on Infective Exacerbations of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. 2020
- A single-center observational study assessing response to mepolizumab in severe eosinophilic asthma. European Respiratory Journal European Respiratory Journal, Supplement. 2019
- The prevalence of bronchitis and associations with spirometry in patients with interstitial lungdisease in a Canadian tertiary care centre. European Respiratory Journal European Respiratory Journal, Supplement. 2019
- Dupilumab reduces oral corticosteroid (OCS) use and severe exacerbations, and improves FEV1 in OCS-dependent, severe asthma with comorbid chronic rhinosinusitis with and without nasal polyps. Allergy: European Journal of Allergy and Clinical Immunology. 35-35. 2019
- Airway Luminal Contributors to Magnetic Resonance Imaging Ventilation Heterogeneity in Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2019
- Increased B-Cells in the Airways of Patients with Severe Eosinophilic Asthma: A Local Auto-Inflammatory Process. American Journal of Respiratory and Critical Care Medicine. 2019
- FACTORS ASSOCIATED WITH DISEASE PROGRESSION IN PATIENTS WITH MYELOPEROXIDASE-ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-RELATED PULMONARY FIBROSIS. Rheumatology. 2019
- Omalizumab in Patients with Severe Asthma and Persistent Sputum Eosinophilia. Journal of Allergy and Clinical Immunology. AB434-AB434. 2019
- Sex Differences in Type 2 Innate Lymphoid Cells in Adult Asthmatics. Journal of Allergy and Clinical Immunology. AB1-AB1. 2019
- Sputum and serum immunoglobulins in patients with asthma and recurrent neutrophilic bronchitis. Journal of Allergy and Clinical Immunology. AB227-AB227. 2019
- Sputum autoantibody-mediated macrophage dysfunction in severe eosinophilic asthmatics with recurrent infections. Journal of Allergy and Clinical Immunology. AB189-AB189. 2019
- Autoantigen Array Reveals Decreased Expression of Autoantibodies in Sputum of Patients with Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. 2019
- High Failure Rate of Anti-IL-5 Therapies in Prednisone-Dependent Asthma Is Associated with Airway Autoimmune Responses. American Journal of Respiratory and Critical Care Medicine. 2019
- Dupilumab in Patients with Corticosteroid-Dependent Severe Asthma: Efficacy and Safety Results from the Randomized, Double-Blind, Placebo-Controlled Phase 3 LIBERTY ASTHMA VENTURE Study. American Journal of Respiratory and Critical Care Medicine. 2018
- Effect of Anti-Th2 Therapy on MRI Ventilation Heterogeneity in Prednisone-Dependent Asthma. American Journal of Respiratory and Critical Care Medicine. 2018
- The Role of HuR in Myofibroblast Differentiation: Implication for Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2018
- Benralizumab attenuates airway eosinophilopoietic processes in prednisone-dependent asthma. European Respiratory Journal European Respiratory Journal, Supplement. 2017
- Weight-adjusted Intravenous Reslizumab Attenuates Airway Eosinophilia in Severe Asthmatics compared to 100 mg Subcutaneous Mepolizumab. European Respiratory Journal European Respiratory Journal, Supplement. 2017
- INCREASED EXPRESSION OF IL-27 IN NEUTROPHILIC ASTHMA. Respirology. 52-52. 2017
- SPUTUM ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODIES (ANCA) IN EOSINOPHILIC GRANULAMATOSIS AND POLYANGIITIS (EGPA). Rheumatology. 17-17. 2017
- Benralizumab Significantly Reduced Oral Corticosteroid Dosages And Asthma Exacerbation Rates For Patients With Severe, Uncontrolled Asthma: Results Of The Zonda Phase Iii Trial. American Journal of Respiratory and Critical Care Medicine. 2017
- Inflammatory And Non-Inflammatory Contributions To Ventilation Heterogeneity In Severe Poorly-Controlled Asthmatics. American Journal of Respiratory and Critical Care Medicine. 2017
- Lncrna Neat1 Promotes Il-8 Expression In Fibroblasts Derived From COPD Patients And In Response To Cigarette Smoking. American Journal of Respiratory and Critical Care Medicine. 2017
- Sputum Il-27 Gene Expression In Asthma Endotypes. American Journal of Respiratory and Critical Care Medicine. 2017
- The Role Of Human Antigen R (hur) In Chronic Obstructive Pulmonary Disease (COPD). American Journal of Respiratory and Critical Care Medicine. 2017
- Pathogenic sputum autoantibodies in eosinophilic severe asthma: a novel autoimmune endotype. Allergy: European Journal of Allergy and Clinical Immunology. 30-30. 2016
- Mepolizumab in COPD with Eosinophilic Bronchitis: A Randomized Clinical Trial. Journal of Allergy and Clinical Immunology. AB392-AB392. 2016
- Nasal and Pharyngeal Eosinophil Peroxidase Levels Represent Surrogate Biomarkers for the Presence of Lower Airway Eosinophils in Adults with Poorly Controlled Asthma. Journal of Allergy and Clinical Immunology. AB108-AB108. 2016
- Pathogenic Autoantibodies in Patients with Severe Asthma and Sputum Eosinophils. Journal of Allergy and Clinical Immunology. AB409-AB409. 2016
- What Do Mri Ventilation Defects Reveal About Asthma Control?. American Journal of Respiratory and Critical Care Medicine. 2016
- Development of a Clinical Lab Assay for Assessment of Eosinophil Peroxidase in Sputum. Journal of Allergy and Clinical Immunology. AB176-AB176. 2015
- Eosinophil Peroxidase As an Autoimmune Target in Eosinophilic Airway Disorders. Journal of Allergy and Clinical Immunology. AB221-AB221. 2015
- Human Bronchial Epithelial Cell-Derived Factors from Severe Asthmatics Can Stimulate Local Eosinophilopoetic Responses. Journal of Allergy and Clinical Immunology. AB148-AB148. 2015
- Fibroblast-Epithelial Cell Interactions In Normal And Obstructive Airway Disease. American Journal of Respiratory and Critical Care Medicine. 2015
- Ventilation Heterogeneity In Severe Asthma: Effects Of Prednisone And Salbutamol Before Bronchial Thermoplasty. American Journal of Respiratory and Critical Care Medicine. 2015
- Aryl Hydrocarbon Receptor Regulation Of Mir-196a Controls Lung Fibroblast Proliferation Via The Cell Cycle Inhibitor P27kip1. American Journal of Respiratory and Critical Care Medicine. 2014
- Upregulation Of Il-17a/f From Human Lung Tissue Explants Exposed To Cigarette Smoke. American Journal of Respiratory and Critical Care Medicine. 2014
- A Multidisciplinary, Multimodality But Minimalist (3M) Approach to Transfemoral Transcatheter Aortic Valve Replacement Facilitates Safe Next Day Discharge in High Risk Patients. Canadian Journal of Cardiology. S227-S227. 2013
- 106. Cytokine. 268-268. 2013
- Hdac And Marco Expression In Patients With Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2013
- Human Lung Fibroblasts Express The High Affinity Receptor For Ige (fc Epsilon Ri). American Journal of Respiratory and Critical Care Medicine. 2013
- Relb Regulates Cox-2 In Cigarette Smoke-Exposed Human Lung Fibroblasts Via Mir-146a Expression. American Journal of Respiratory and Critical Care Medicine. 2013
- The Aryl Hydrocarbon Receptor Attenuates Cytoplasmic Translocation Of Hur And Subsequent Cox-2 Production In Human Lung Fibroblasts. American Journal of Respiratory and Critical Care Medicine. 2013
- Vector quantization, density estimation and outlier detection on cricket dataset. 2013 International Conference on Computer Communication and Informatics. 2013
- 406 Clinical utility of transthoracic echocardiography in patients with atrial fibrillation undergoing evaluation for suspected stroke. Canadian Journal of Cardiology. S208-S208. 2011
- 518 Safety and feasibility of accelerated dobutamine-atropine stress echocardiography. Canadian Journal of Cardiology. S251-S251. 2011
- A novel ELISA for eosinophil peroxidase provides a sensitive high throughput assay for eosinophil degranulation in either mouse or human biological samples. Journal of Immunology. 2011
- Efficacy of Reslizumab in Patients with Poorly Controlled Eosinophilic Asthma: Subgroup Analysis of Patients with Nasal Polyps. Journal of Allergy and Clinical Immunology. AB84-AB84. 2011
- Sputum Hyaluronan as a Biomarker of Airway Remodeling in Severe Asthma. Journal of Allergy and Clinical Immunology. AB8-AB8. 2011
- A Pilot Study To Investigate The Proteomics Profile Of Asthmatic Patients With Varying Types Of Bronchitis. American Journal of Respiratory and Critical Care Medicine. 2011
- Modulation Of Airway Smooth Muscle Proliferation, Migration And Contractility By Adipocytes. American Journal of Respiratory and Critical Care Medicine. 2011
- The Expression Of Cytokines In The Peripheral Lung Of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. 2011
- PS2-27 Bioactive oncostatin m is present in induced-sputum samples from house dust mite -sensitive asthmatic subjects. Cytokine. 56-56. 2010
- Decline of Pulmonary Function in Asthmatic Subjects with Persistent Airway Neutrophilia. American Journal of Respiratory and Critical Care Medicine. 2010
- SCH527123, a Novel Treatment Option For Severe Neutrophilic Asthma. American Journal of Respiratory and Critical Care Medicine. 2010
- Genomic Wide Expression Study (GWES) of Induced Sputum in Asthma.. American Journal of Respiratory and Critical Care Medicine. 2009
- Increased Function and Lung-Homing of Progenitor Cells in Patients with COPD Compared to Normals.. American Journal of Respiratory and Critical Care Medicine. 2009
- Pulmonary Function and Lower Airway Inflammation in Elderly Asthmatic Subjects.. American Journal of Respiratory and Critical Care Medicine. 2009
- Knowledge, Risk perception, Poultry workers and Avian influenza. International Journal of Infectious Diseases. e128-e128. 2008
- Effect of a community screening and eradication program for Helicobacter pylori infection on consultations for dyspepsia: Seven year follow-up of the Bristol Helicobacter project. Gastroenterology. A142-A142. 2008
- Implantable cardioverter-defibrillators in ventricular assist device-supported heart failure patients bridged to cardiac transplant. Circulation. U460-U460. 2005
- Implantable cardioverter-defibrillators in ventricular assist device-supported heart failure patients bridged to cardiac transplantation. Journal of Cardiac Failure. S135-S135. 2005
- The role of alloantibody in neonatally-induced cardiac allograft acceptance.. American Journal of Transplantation. 430-431. 2005
- Clinicocolonoscopic Differentiation of Tuberculosis From Crohn's Disease. Gastrointestinal Endoscopy. AB263-AB263. 2005
- Risk factors for poor outcomes in ventricular assist devices: The Pittsburgh bridge to transplant experience. Journal of the American College of Cardiology. 132A-133A. 2005
- Activation of adenosine A(1)/A(3) receptors protects cardiomyocytes by enhancing cell volume regulation. Journal of Molecular and Cellular Cardiology. 630-630. 2004
- A MRF based segmentatiom approach to classification using Dempster Shafer fusion for multisensor imagery. Lecture Notes in Computer Science. 421-428. 2004
- Boundary layer aerosols at Trivandrum tropical coast. Advances in Space Research. 838-844. 2004
- Chemical composition of atmospheric aerosols over the Indian Ocean: impact of continental advection. Advances in Space Research. 828-832. 2004
- Impact of Indonesian forest fires during the 1997 El Nino on the aerosol distribution over the Indian Ocean. Advances in Space Research. 1098-1103. 2004
- Lidar observations of high altitude cirrus clouds near the tropical tropopause. Advances in Space Research. 845-850. 2004
- A study of equatorial wave characteristics using rockets, balloons, lidar and radar. Advances in Space Research. 813-818. 2003
- Gravity waves in the tropical middle atmosphere: Characteristics and wave-mean flow interaction. Advances in Space Research. 807-812. 2003
- RAM: a conserved signaling network that regulates Ace2p transcription factor and polarized morphogenesis.. Yeast. S63-S63. 2003
- Diazoxide reduces ischemic swelling by enhancing cell volume regulation in rabbit ventricular myocytes. Journal of Molecular and Cellular Cardiology. A24-A24. 2003
- Accurate semi-empirical model for annealed proton. exchanged waveguides in Z-cut lithium niobate. Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS. 338-339. 2003
- <title>Seasonal and interannual variability of regional aerosol distribution over the Indian Ocean observed using NOAA-14 AVHRR</title>. Proceedings of SPIE - The International Society for Optical Engineering. 238-247. 2002
- Optical properties of cirrus clouds observed below the tropical tropopause. Proceedings of SPIE - The International Society for Optical Engineering. 186-197. 2002
- Rayleigh lidar observations of gravity wave characteristics in the middle atmosphere at Gadanki, India (13.5 degrees N, 79.2 degreesE.). Proceedings of SPIE - The International Society for Optical Engineering. 286-294. 2002
- Increased numbers of eosinophils in bronchial biopsies of atopic asthmatics after LTE4 butnotLTD4 inhalation. Journal of Allergy and Clinical Immunology. S142-S142. 2001
- The design and performance of meta-programming mechanisms for object request broker middleware. 6TH USENIX CONFERENCE OF OBJECT-ORIENTED TECHNOLOGIES AND SYSTEMS (COOTS 01). 103-118. 2001
- Applying reflective middleware techniques to optimize a QoS-enabled CORBA component model implementation. Proceedings - International Computer Software and Applications Conference. 492-499. 2000
- Parametric wavelength conversion and phase conjugation in LiNbO3 waveguides. Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS. 766-767. 2000
- Waveguide frequency mixers for all-optical signal processing. OSA Trends in Optics and Photonics Series. 156-158. 2000
- Lipid-laden macrophages in sputum is a marker of acid microaspiration. Gastroenterology. A110-A110. 1999
- Apoptotic eosinophils in induced sputum after allergen challenge: Effect of fluticasone.. American Journal of Respiratory and Critical Care Medicine. A848-A848. 1999
- Effects of fluticasone on allergen-induced airway responses: Single dose versus two weeks treatment.. American Journal of Respiratory and Critical Care Medicine. A633-A633. 1999
- Effects of fluticasone on allergen-induced inflammation in sputum: Single dose versus two weeks treatment.. American Journal of Respiratory and Critical Care Medicine. A853-A853. 1999
- Lipid-laden macrophages in induced sputum: A marker of acid aspiration in gastro-esophageal reflux. American Journal of Respiratory and Critical Care Medicine. A514-A514. 1999
- Protection against methacholine airway constriction: A valid assessment of bio-equivalence of inhaled beta-2 agonists.. American Journal of Respiratory and Critical Care Medicine. A877-A877. 1999
- Substance P and albumin in non-asthmatic non-eosinophilic chronic cough.. American Journal of Respiratory and Critical Care Medicine. A534-A534. 1999
- Quasi-phase-matched waveguides: From ultrashort pulses to signal processing for optical communications. ECIO'99: 9TH EUROPEAN CONFERENCE ON INTEGRATED OPTICS AND TECHNICAL EXHIBITION. 497-500. 1999
- Studies on the nature of surface quality in precision grinding of carbon steels. PROCEEDINGS OF THE FOURTEENTH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR PRECISION ENGINEERING. 91-94. 1999
- Reliability of radiographic scoring of degenerative changes in the lumbar spine (DCLS).. Arthritis and Rheumatism. S146-S146. 1998
- Clinical judgment of airway inflammation versus sputum cell counts in asthma.. Journal of Allergy and Clinical Immunology. S116-S116. 1998
- Treatment and disposal of domestic sewage sludge and nightsoil sludge for Bangkok. Water Science and Technology Progress in Water Technology. 209-217. 1996
- An enabler architecture for computer-supported cooperative work applications. Proceedings of TENCON'94 - 1994 IEEE Region 10's 9th Annual International Conference on: 'Frontiers of Computer Technology'. 249-253. 1994
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thesis