Journal article
Human Bronchial Epithelial Cell–derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil Differentiation
Abstract
Activated bronchial epithelial cells (BEC) release various alarmins, including thymic stromal lymphopoietin (TSLP), that drive type 2 inflammation. We hypothesize that BEC-derived factors promote in situ eosinophil differentiation and maturation, a process that is driven by an IL-5-rich microenvironment in asthmatic airways. To assess the eosinophilopoietic potential of epithelial-derived factors, eosinophil/basophil colony forming units …
Authors
Salter BMA; Smith SG; Mukherjee M; Plante S; Krisna S; Nusca G; Oliveria JP; Irshad A; Gauvreau GM; Chakir J
Journal
American Journal of Respiratory Cell and Molecular Biology, Vol. 58, No. 1, pp. 99–106
Publisher
American Thoracic Society
Publication Date
January 2018
DOI
10.1165/rcmb.2016-0262oc
ISSN
1044-1549