Journal article
The effects of rituximab on serum IgE and BAFF
Abstract
BackgroundThere are few treatment options for patients with severe atopic asthma. Antagonism of IgE is an effective strategy. We investigated, by utilizing serum samples from a clinical trial of Rituximab in patients with Idiopathic Thrombocytopenic Purpura, if B cell depletion would decrease serum IgE and therefore be a potential therapeutic option.FindingsIn a placebo-controlled randomized clinical trial of Rituximab, an anti-CD20 molecule, …
Authors
Dasgupta A; Radford K; Arnold DM; Thabane L; Nair P
Journal
Allergy, Asthma & Clinical Immunology, Vol. 9, No. 1,
Publisher
Springer Nature
Publication Date
December 2013
DOI
10.1186/1710-1492-9-39
ISSN
1710-1484