Journal article
A population of c-kit+ IL-17A+ ILC2s in sputum from individuals with severe asthma supports ILC2 to ILC3 trans-differentiation
Abstract
In prednisone-dependent severe asthma, uncontrolled sputum eosinophilia is associated with increased numbers of group 2 innate lymphoid cells (ILC2s). These cells represent a relatively steroid-insensitive source of interleukin-5 (IL-5) and IL-13 and are considered critical drivers of asthma pathology. The abundance of ILC subgroups in severe asthma with neutrophilic or mixed granulocytic (both eosinophilic and neutrophilic) airway …
Authors
Ju X; Fard NE; Bhalla A; Dvorkin-Gheva A; Xiao M; Radford K; Zhang K; Ditta R; Oliveria JP; Paré G
Journal
Science Translational Medicine, Vol. 17, No. 781,
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
January 15, 2025
DOI
10.1126/scitranslmed.ado6649
ISSN
1946-6234