Journal article
Airway Eosinophilopoietic and Autoimmune Mechanisms of Eosinophilia in Severe Asthma
Abstract
Eosinophils are critical in asthma biology, contributing to symptoms, airflow obstruction, airway hyperresponsiveness, and remodeling. In severe asthma, in addition to local maturation in bone marrow, in situ eosinophilopoiesis plays a key role in the persistence of airway eosinophilia. Local milieu of structural, epithelial and inflammatory cells contribute by generating eosinophilopoietic cytokines in response to epithelial-derived alarmins. …
Authors
Bhalla A; Mukherjee M; Nair P
Journal
Immunology and Allergy Clinics of North America, Vol. 38, No. 4, pp. 639–654
Publisher
Elsevier
Publication Date
November 2018
DOI
10.1016/j.iac.2018.06.003
ISSN
0889-8561