Journal article
Sputum Hyaluronan and Versican in Severe Eosinophilic Asthma
Abstract
BACKGROUND: We examined levels of hyaluronan, a matrix glycosaminoglycan and versican, a matrix proteoglycan, in the sputum of asthmatics treated with mepolizumab (anti-IL-5 monoclonal antibody) versus placebo to evaluate the utility of these measurements as possible biomarkers of asthma control and airway remodeling.
METHODS: Patients with severe, prednisone-dependent asthma received either mepolizumab or placebo as described in a previously …
Authors
Ayars AG; Altman LC; Potter-Perigo S; Radford K; Wight TN; Nair P
Journal
International Archives of Allergy and Immunology, Vol. 161, No. 1, pp. 65–73
Publisher
Karger Publishers
Publication Date
2013
DOI
10.1159/000343031
ISSN
1018-2438