Journal article
Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia
Abstract
BACKGROUND: In patients with severe eosinophilic asthma, local maturation rather than systemic recruitment of mature cells might contribute to persistent airway eosinophilia. Group 2 innate lymphoid cells (ILC2s) are a major source of type 2 cytokines (IL-5 and IL-13) and can facilitate eosinophilic inflammatory responses in mouse models of asthma in the absence of CD4+ lymphocytes. This study investigated the potential role of ILC2s in driving …
Authors
Smith SG; Chen R; Kjarsgaard M; Huang C; Oliveria J-P; O'Byrne PM; Gauvreau GM; Boulet L-P; Lemiere C; Martin J
Journal
The Journal of Allergy and Clinical Immunology, Vol. 137, No. 1, pp. 75–86.e8
Publisher
Elsevier
Publication Date
January 2016
DOI
10.1016/j.jaci.2015.05.037
ISSN
0091-6749