Journal article
The Effects of Leptin on Airway Smooth Muscle Responses
Abstract
Obesity is associated with asthma and airway hyperresponsiveness. Leptin modulates some of the proinflammatory effects observed in obesity. The objective of this study was to determine the effects of leptin on airway smooth muscle responses. The effect of leptin (0.1-100 ng/ml) on migration (toward platelet-derived growth factor [PDGF], 10 ng/ml, across collagen-coated membrane in Transwell culture plates), proliferation (by BrDU …
Authors
Nair P; Radford K; Fanat A; Janssen LJ; Peters-Golden M; Cox PG
Journal
American Journal of Respiratory Cell and Molecular Biology, Vol. 39, No. 4, pp. 475–481
Publisher
American Thoracic Society
Publication Date
10 2008
DOI
10.1165/rcmb.2007-0091oc
ISSN
1044-1549