Down-Regulation
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15-Deoxy-Δ12,14-prostaglandin J2 down-regulates CXCR4 on carcinoma cells through PPARγ- and NFκB-mediated pathways Academic Article
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4-Phenylbutyrate Inhibits Tunicamycin-Induced Acute Kidney Injury via CHOP/GADD153 Repression Academic Article
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A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion Academic Article
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ADAMTS-13 metalloprotease abnormalities in systemic lupus erythematosus: is there a correlation with disease status? Academic Article
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AMP-Activated Protein Kinase Is Not Down-Regulated in Human Skeletal Muscle of Obese Females Academic Article
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Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathway Academic Article
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Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction. Academic Article
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Adenovirus-Mediated Gene Transfer of TGF-β1 to the Renal Glomeruli Leads to Proteinuria Academic Article
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Adenylyl Cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice Academic Article
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Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines Academic Article
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Anti-sRAGE autoimmunity in obesity: Downturn after bariatric surgery is independent of previous diabetic status Academic Article
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Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells Academic Article
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Apatorsen plus docetaxel versus docetaxel alone in platinum-resistant metastatic urothelial carcinoma (Borealis-2) Academic Article
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Aromatase Inhibitor Exemestane has Antiproliferative Effects on Human Mesothelioma Cells Academic Article
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Assessment of the cardioprotective effect of liraglutide on methotrexate induced cardiac dysfunction through suppression of inflammation and enhancement of angiogenesis in rats. Academic Article
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Bifidobacterium infantis NLS Super Strain Reduces the Expression of α-Defensin-5, a Marker of Innate Immunity, in the Mucosa of Active Celiac Disease Patients Academic Article
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Butein impairs the protumorigenic activity of malignant pleural mesothelioma cells Academic Article
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CREB expression mediates amyloid β-induced basal BDNF downregulation Academic Article
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Carnosine, taurine and enzyme activities of human skeletal muscle fibres from elderly subjects with osteoarthritis and young moderately active subjects Academic Article
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Changes in parvalbumin immunoreactive retinal ganglion cells and amacrine cells after optic nerve injury Academic Article
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Chronic β2-adrenoceptor stimulation impairs cardiac relaxation via reduced SR Ca2+-ATPase protein and activity Academic Article
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Cigarette Smoke Exposure Leads to Follicle Loss via an Alternative Ovarian Cell Death Pathway in a Mouse Model Academic Article
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Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis inSmad3knockout mice Academic Article
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Cl−transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+channels (ENaCs) inXenopusoocytes co-expressing CFTR and ENaC Academic Article
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Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway Academic Article
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Conditional Deletion of AP-2β in the Periocular Mesenchyme of Mice Alters Corneal Epithelial Cell Fate and Stratification Academic Article
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Contactin-1 Reduces E-Cadherin Expression Via Activating AKT in Lung Cancer Academic Article
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Critical Negative Regulation of Type 1 T Cell Immunity and Immunopathology by Signaling Adaptor DAP12 during Intracellular Infection Academic Article
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Dabigatran etexilate and reduction in serum apolipoprotein B Academic Article
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Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease Academic Article
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Decreased Expression of Cerebral Dopamine Neurotrophic Factor in Platelets of Stroke Patients Academic Article
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Desensitization of D1 dopamine receptors down-regulates the Gsα subunit of G protein in SK-N-MC neuroblastoma cells Academic Article
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Development of the embryonic heat shock response and the impact of repeated thermal stress in early stage lake whitefish ( Coregonus clupeaformis ) embryos Academic Article
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Differential mechanisms of posterior cingulate cortex downregulation and symptom decreases in posttraumatic stress disorder and healthy individuals using real‐time fMRI neurofeedback Academic Article
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Differential proteomic analysis of renal tissue in mesangial proliferative glomerulonephritis using iTRAQ technology Academic Article
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Differential regulation of striatal G protein levels following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration in C57 BL/6 mice Academic Article
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Discovery of Novel Hypermethylated Genes in Prostate Cancer Using Genomic CpG Island Microarrays Academic Article
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Dopamine sudden depletion as a model for mixed depression Academic Article
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Dosing regimen differentiates sensitization of locomotion and mouthing to D2 agonist quinpirole Academic Article
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Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system Academic Article
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Downregulation of BM88 After Optic Nerve Injury Academic Article
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Downregulation of Na+-K+-ATPase pumps in skeletal muscle with training in normobaric hypoxia Academic Article
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Downregulation of microRNAs 145-3p and 145-5p Is a Long-term Predictor of Postmenopausal Breast Cancer Risk: The ORDET Prospective Study Academic Article
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Effect of contact lens material on cytotoxicity potential of multipurpose solutions using human corneal epithelial cells. Academic Article
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Effect of loxapine on peripheral dopamine-like and serotonin receptors in patients with schizophrenia. Academic Article
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Effects of Electroconvulsive Therapy on Peripheral Adrenoceptors, Plasma, Noradrenaline, MHPG and Cortisol in Depressed Patients Academic Article
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Endogenous protein C activation in patients with severe sepsis Academic Article
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Epigenetic silencing of miR-145-5p contributes to brain metastasis Academic Article
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Epigenetic therapy inhibits metastases by disrupting premetastatic niches Academic Article
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Ethylenecarbodiimide-fixed splenocytes carrying whole islet antigens decrease the incidence of diabetes in NOD mice <i>via</i> down-regulation of effector memory T cells and autoantibodies Academic Article
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Evidence that Herpes Simplex Virus VP16 Is Required for Viral Egress Downstream of the Initial Envelopment Event Academic Article
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Expression of the 1,25-dihydroxyvitamin D3-24-hydroxylase gene in rat intestine: Response to calcium, vitamin D3 and calcitriol administration in vivo Academic Article
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Extracellular Matrix and Fibrocyte Accumulation in BALB/c Mouse Lung upon Transient Overexpression of Oncostatin M Academic Article
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FGF-Regulated Etv Genes Are Essential for Repressing Shh Expression in Mouse Limb Buds Academic Article
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Functional Expression of Neurokinin 1 Receptors on Mast Cells Induced by IL-4 and Stem Cell Factor Academic Article
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Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic β-cells Academic Article
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Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression Academic Article
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Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells Academic Article
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Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins Academic Article
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Gene expression endpoints following chronic waterborne copper exposure in a genomic model organism, the zebrafish, Danio rerio Academic Article
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Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis Academic Article
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Glucosamine-Induced Endoplasmic Reticulum Stress Promotes ApoB100 Degradation Academic Article
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HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions Academic Article
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Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5 Academic Article
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High Salt Intake Increases Blood Pressure via BDNF-Mediated Downregulation of KCC2 and Impaired Baroreflex Inhibition of Vasopressin Neurons Academic Article
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Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice Academic Article
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Identification of Myopia-Related Marker Proteins in Tilapia Retinal, RPE, and Choroidal Tissue following Induced Form Deprivation Academic Article
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Identification of periplakin as a major regulator of lung injury and repair in mice Academic Article
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Impact of blood pressure lowering, cholesterol lowering and their combination in Asians and non-Asians in those without cardiovascular disease: an analysis of the HOPE 3 study Academic Article
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Inability of Human Induced Pluripotent Stem Cell-Hematopoietic Derivatives to Downregulate MicroRNAs In Vivo Reveals a Block in Xenograft Hematopoietic Regeneration Academic Article
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Increased pro–nerve growth factor and decreased brain-derived neurotrophic factor in non–Alzheimer's disease tauopathies Academic Article
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Infectious salmon anaemia virus (ISAV) isolates induce distinct gene expression responses in the Atlantic salmon (Salmo salar) macrophage/dendritic-like cell line TO, assessed using genomic techniques Academic Article
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Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis Academic Article
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Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin Academic Article
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Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra Academic Article
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Interleukin-10 and nerve growth factor have reciprocal upregulatory effects on intestinal epithelial cells Academic Article
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Limb Immobilization Induces a Coordinate Down-Regulation of Mitochondrial and Other Metabolic Pathways in Men and Women Academic Article
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Live
Lactobacillus reuteri
Is Essential for the Inhibitory Effect on Tumor Necrosis Factor Alpha-Induced Interleukin-8 Expression Academic Article
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Long-lasting conditioning of the human soleus H reflex following quadriceps tendon tap Academic Article
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Low intensity training decreases markers of oxidative stress in skeletal muscle of mdx mice Academic Article
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MYC Is Activated by USP2a-Mediated Modulation of MicroRNAs in Prostate Cancer Academic Article
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Markedly decreased expression of TAP1 and LMP2 genes in HLA class I-deficient human tumor cell lines Academic Article
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Matrix Metalloproteinase-19 Promotes Metastatic Behavior In Vitro and Is Associated with Increased Mortality in Non–Small Cell Lung Cancer Academic Article
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Menin Is a Regulator of the Stress Response in
Drosophila melanogaster Academic Article
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Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK Academic Article
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Modular pharmacology-based approach to identify hub genes and kernel pathways of taodan granules treated psoriasis Academic Article
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Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis Academic Article
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Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15 Academic Article
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Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells Academic Article
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Mutant p53 Enhances Nuclear Factor κB Activation by Tumor Necrosis Factor α in Cancer Cells Academic Article
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Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts Academic Article
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NT-3 modulates BDNF and proBDNF levels in naïve and kindled rat hippocampus Academic Article
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Na+,K+-ATPase concentration and fiber type distribution after spinal cord injury Academic Article
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Neurofibrillary Tangles and Senile Plaques in Alzheimers Brains are Associated with Reduced Capillary Expression of Vascular Endothelial Growth Factor and Endothelial Nitric Oxide Synthase Academic Article
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Object recognition memory and BDNF expression are reduced in young TgCRND8 mice Academic Article
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Oestrogen receptor downregulation: an opportunity for extending the window of endocrine therapy in advanced breast cancer Academic Article
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Oligomeric Amyloid Decreases Basal Levels of Brain-Derived Neurotrophic factor (BDNF) mRNA via Specific Downregulation of BDNF Transcripts IV and V in Differentiated Human Neuroblastoma Cells Academic Article
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Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation Academic Article
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Overexpression of MyoD-inducible lysosomal sialidase (neu1) inhibits myogenesis in C2C12 cells Academic Article
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Overexpression of the Endoplasmic Reticulum 60 Protein ER-60 Downregulates ApoB100 Secretion by Inducing Its Intracellular Degradation via a Nonproteasomal Pathway: Evidence for an ER-60-Mediated and pCMB-Sensitive Intracellular Degradative Pathway Academic Article
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Oxidative stress contributes to the induction and persistence of TGF-β1 induced pulmonary fibrosis Academic Article
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PGC‐1α gene expression is down‐regulated by Akt‐mediated phosphorylation and nuclear exclusion of FoxO1 in insulin‐stimulated skeletal muscle Academic Article
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Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo Academic Article
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Perinatal Phenotype and Hypothyroidism Are Associated with Elevated Levels of 21.5- to 22-kDa Basic Fibroblast Growth Factor in Cardiac Ventricles Academic Article
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Peripheral Blood Gene Expression Changes during Allergen Inhalation Challenge in Atopic Asthmatic Individuals Academic Article
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Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9 Academic Article
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Phosphorylation of mitochondrial phospholipid scramblase 3 by protein kinase C-δ induces its activation and facilitates mitochondrial targeting of tBid Academic Article
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Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis Academic Article
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Polymorphism of the beta2-adrenoceptor and the response to long-term beta2-agonist therapy in asthma. Academic Article
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Pre-exposure to Waterborne Nickel Downregulates Gastrointestinal Nickel Uptake in Rainbow Trout: Indirect Evidence for Nickel Essentiality Academic Article
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Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease Academic Article
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Preneoplastic changes persist after IGF-IR downregulation and tumor regression Academic Article
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Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer’s disease Academic Article
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Prognostic Implications of the Immunohistochemical Expression of Human Kallikreins 5, 6, 10 and 11 in Renal Cell Carcinoma Academic Article
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Progressive Transforming Growth Factor β1–induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor Academic Article
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Proteomic analysis of common bean seed with storage protein deficiency reveals up-regulation of sulfur-rich proteins and starch and raffinose metabolic enzymes, and down-regulation of the secretory pathway Conference Paper
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Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma Academic Article
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Reduced resting skeletal muscle protein synthesis is rescued by resistance exercise and protein ingestion following short-term energy deficit Academic Article
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Regulation of the adaptor molecule LAT2, an in vivo target gene of AML1/ETO (RUNX1/RUNX1T1), during myeloid differentiation Academic Article
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Renal tubular angiogenic dysregulation in anti-Thy1.1 glomerulonephritis Academic Article
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Response of oxidative stress transcripts in the brain of wild yellow perch (Perca flavescens) exposed to an environmental gradient of methylmercury Academic Article
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Saffron Pre-Treatment Promotes Reduction in Tissue Inflammatory Profiles and Alters Microbiome Composition in Experimental Colitis Mice Academic Article
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Self-adjoint sensitivity analysis of lossy dielectric structures with electromagnetic time-domain simulators Academic Article
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Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis Academic Article
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Serological tests for celiac disease as indicators of long-term compliance with the gluten-free diet Academic Article
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Serotonin Activates Dendritic Cell Function in the Context of Gut Inflammation Academic Article
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Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice Academic Article
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Silent but deadly: IS200 promotes pathogenicity in Salmonella Typhimurium Academic Article
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Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation Academic Article
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Specific Reduction of Fas-Associated Protein with Death Domain (FADD) in Clear Cell Renal Cell Carcinoma Academic Article
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Specific attenuation of protein kinase phosphorylation in muscle with a high mitochondrial content Academic Article
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State-of-the-Art-Review : Statins Induce Hypothrombotic States? Academic Article
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Statins and Thrombin Academic Article
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Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion Academic Article
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Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4 Academic Article
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Surfactant dysfunction during overexpression of TGF-β1 precedes profibrotic lung remodeling in vivo Academic Article
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T Cell Epitope Immunotherapy Induces a CD4+ T Cell Population with Regulatory Activity Academic Article
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T cells and the immune response: down-regulation via mucosal exposure. Academic Article
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TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state Academic Article
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TNF-α is a critical negative regulator of type 1 immune activation during intracellular bacterial infection Academic Article
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TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway Academic Article
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Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease Academic Article
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The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses Academic Article
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The Effect of Paroxetine on 5-HT2AReceptors in Depression: An [18F]Setoperone PET Imaging Study Academic Article
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The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses Academic Article
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The NK Receptor NKp30 Mediates Direct Fungal Recognition and Killing and Is Diminished in NK Cells from HIV-Infected Patients Academic Article
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The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice Academic Article
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The Pseudomonas aeruginosa PilSR Two-Component System Regulates Both Twitching and Swimming Motilities Academic Article
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The YebC Family Protein PA0964 Negatively Regulates the
Pseudomonas aeruginosa
Quinolone Signal System and Pyocyanin Production Academic Article
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The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the β-catenin/TCF target gene matrilysin Academic Article
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The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis Academic Article
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The obesity epidemic: the role of addiction Academic Article
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The pituitary gonadotropin-releasing hormone (GnRH) receptor of the female rabbit: characterization and developmental aspects Academic Article
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The plant signal salicylic acid shuts down expression of the
vir
regulon and activates quormone-quenching genes in
Agrobacterium Academic Article
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The role of TWIST as a regulator in giant cell tumor of bone Academic Article
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Therapeutic levels of human Factor VIII in mice implanted with encapsulated cells: potential for gene therapy of haemophilia A Academic Article
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Thiazolidinedione drugs down-regulate CXCR4 expression on human colorectal cancer cells in a peroxisome proliferator activated receptor γ-dependent manner Academic Article
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Time-dependent Effect of Kainate-induced Seizures on Glutamate Receptor GluR5, GluR6, and GluR7 mRNA and Protein Expression in Rat Hippocampus Academic Article
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Toxicogenomic Analysis of Mainstream Tobacco Smoke-Exposed Mice Reveals Repression of Plasminogen Activator Inhibitor-1 Gene in Heart Academic Article
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Transcriptional Profiling Implicates Novel Interactions between Abiotic Stress and Hormonal Responses in Thellungiella, a Close Relative of Arabidopsis
Academic Article
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Transcriptional effects of hypoxia on fusiogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons Academic Article
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Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73 Academic Article
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USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway Academic Article
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cAMP response element–binding protein is expressed at high levels in human ovarian adenocarcinoma and regulates ovarian tumor cell proliferation Academic Article
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miR‐10b*, a master inhibitor of the cell cycle, is down‐regulated in human breast tumours Academic Article