Down-Regulation Concept

subject area of

• 15-Deoxy-Δ12,14-prostaglandin J2 down-regulates CXCR4 on carcinoma cells through PPARγ- and NFκB-mediated pathways  Journal Articles
• 4-Phenylbutyrate Inhibits Tunicamycin-Induced Acute Kidney Injury via CHOP/GADD153 Repression  Journal Articles
• A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion  Journal Articles
• ADAMTS-13 metalloprotease abnormalities in systemic lupus erythematosus: is there a correlation with disease status?  Journal Articles
• AMP-Activated Protein Kinase Is Not Down-Regulated in Human Skeletal Muscle of Obese Females  Journal Articles
• Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathway  Journal Articles
• Adenoviral Vector-Mediated Overexpression of IL-4 in the Knee Joint of Mice with Collagen-Induced Arthritis Prevents Cartilage Destruction  Journal Articles
• Adenovirus-Mediated Gene Transfer of TGF-β1 to the Renal Glomeruli Leads to Proteinuria  Journal Articles
• Adenylyl Cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice  Journal Articles
• Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines  Journal Articles
• Anti-sRAGE autoimmunity in obesity: Downturn after bariatric surgery is independent of previous diabetic status  Journal Articles
• Apatorsen plus docetaxel versus docetaxel alone in platinum-resistant metastatic urothelial carcinoma (Borealis-2)  Journal Articles
• Aromatase Inhibitor Exemestane has Antiproliferative Effects on Human Mesothelioma Cells  Journal Articles
• Assessment of the cardioprotective effect of liraglutide on methotrexate induced cardiac dysfunction through suppression of inflammation and enhancement of angiogenesis in rats.  Journal Articles
• Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1.  Journal Articles
• Bifidobacterium infantis NLS Super Strain Reduces the Expression of α-Defensin-5, a Marker of Innate Immunity, in the Mucosa of Active Celiac Disease Patients  Journal Articles
• Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression.  Journal Articles
• Butein impairs the protumorigenic activity of malignant pleural mesothelioma cells  Journal Articles
• CREB expression mediates amyloid β-induced basal BDNF downregulation  Journal Articles
• Carnosine, taurine and enzyme activities of human skeletal muscle fibres from elderly subjects with osteoarthritis and young moderately active subjects  Journal Articles
• Changes in parvalbumin immunoreactive retinal ganglion cells and amacrine cells after optic nerve injury  Journal Articles
• Chronic β₂-adrenoceptor stimulation impairs cardiac relaxation via reduced SR Ca²⁺-ATPase protein and activity  Journal Articles
• Cigarette Smoke Exposure Leads to Follicle Loss via an Alternative Ovarian Cell Death Pathway in a Mouse Model  Journal Articles
• Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis inSmad3knockout mice  Journal Articles
• Cl⁻ transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na⁺ channels (ENaCs) in Xenopus oocytes co‐expressing CFTR and ENaC  Journal Articles
• Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway  Journal Articles
• Conditional Deletion of AP-2β in the Periocular Mesenchyme of Mice Alters Corneal Epithelial Cell Fate and Stratification  Journal Articles
• Contactin-1 Reduces E-Cadherin Expression Via Activating AKT in Lung Cancer  Journal Articles
• Critical Negative Regulation of Type 1 T Cell Immunity and Immunopathology by Signaling Adaptor DAP12 during Intracellular Infection  Journal Articles
• Dabigatran etexilate and reduction in serum apolipoprotein B  Journal Articles
• Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease  Journal Articles
• Decreased Expression of Cerebral Dopamine Neurotrophic Factor in Platelets of Stroke Patients  Journal Articles
• Desensitization of D1 dopamine receptors down-regulates the Gsα subunit of G protein in SK-N-MC neuroblastoma cells  Journal Articles
• Development of the embryonic heat shock response and the impact of repeated thermal stress in early stage lake whitefish ( Coregonus clupeaformis ) embryos  Journal Articles
• Differential mechanisms of posterior cingulate cortex downregulation and symptom decreases in posttraumatic stress disorder and healthy individuals using real‐time fMRI neurofeedback  Journal Articles
• Differential proteomic analysis of renal tissue in mesangial proliferative glomerulonephritis using iTRAQ technology  Journal Articles
• Differential regulation of striatal G protein levels following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration in C57 BL/6 mice  Journal Articles
• Discovery of Novel Hypermethylated Genes in Prostate Cancer Using Genomic CpG Island Microarrays  Journal Articles
• Dopamine sudden depletion as a model for mixed depression  Journal Articles
• Dosing regimen differentiates sensitization of locomotion and mouthing to D2 agonist quinpirole  Journal Articles
• Downregulation of BM88 After Optic Nerve Injury  Journal Articles
• Downregulation of Na⁺-K⁺-ATPase pumps in skeletal muscle with training in normobaric hypoxia  Journal Articles
• Downregulation of microRNAs 145-3p and 145-5p Is a Long-term Predictor of Postmenopausal Breast Cancer Risk: The ORDET Prospective Study  Journal Articles
• Down‐regulated miRs specifically correlate with non‐cardial gastric cancers and Lauren's classification system  Journal Articles
• Down‐regulation of myeloid cell leukemia 1 by epigallocatechin‐3‐gallate sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor α–induced apoptosis  Journal Articles
• Effect of contact lens material on cytotoxicity potential of multipurpose solutions using human corneal epithelial cells.  Journal Articles
• Effect of loxapine on peripheral dopamine-like and serotonin receptors in patients with schizophrenia.  Journal Articles
• Effects of Electroconvulsive Therapy on Peripheral Adrenoceptors, Plasma, Noradrenaline, MHPG and Cortisol in Depressed Patients  Journal Articles
• Endogenous protein C activation in patients with severe sepsis  Journal Articles
• Epigenetic silencing of miR-145-5p contributes to brain metastasis  Journal Articles
• Epigenetic therapy inhibits metastases by disrupting premetastatic niches  Journal Articles
• Essential role of Ahnak in adipocyte differentiation leading to the transcriptional regulation of Bmpr1α expression  Journal Articles
• Ethylenecarbodiimide-fixed splenocytes carrying whole islet antigens decrease the incidence of diabetes in NOD mice <i>via</i> down-regulation of effector memory T cells and autoantibodies  Journal Articles
• Evidence that Herpes Simplex Virus VP16 Is Required for Viral Egress Downstream of the Initial Envelopment Event  Journal Articles
• Expression of the 1,25-dihydroxyvitamin D3-24-hydroxylase gene in rat intestine: Response to calcium, vitamin D3 and calcitriol administration in vivo  Journal Articles
• Extracellular Matrix and Fibrocyte Accumulation in BALB/c Mouse Lung upon Transient Overexpression of Oncostatin M  Journal Articles
• FGF-Regulated Etv Genes Are Essential for Repressing Shh Expression in Mouse Limb Buds  Journal Articles
• Functional Expression of Neurokinin 1 Receptors on Mast Cells Induced by IL-4 and Stem Cell Factor  Journal Articles
• Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression  Journal Articles
• Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells  Journal Articles
• Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins  Journal Articles
• Gene expression endpoints following chronic waterborne copper exposure in a genomic model organism, the zebrafish, Danio rerio  Journal Articles
• Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis  Journal Articles
• Glucosamine-Induced Endoplasmic Reticulum Stress Promotes ApoB100 Degradation  Journal Articles
• HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions  Journal Articles
• Hepatitis C Virus-Induced Degradation of Cell Death-Inducing DFFA-Like Effector B Leads to Hepatic Lipid Dysregulation.  Journal Articles
• Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5  Journal Articles
• High Salt Intake Increases Blood Pressure via BDNF-Mediated Downregulation of KCC2 and Impaired Baroreflex Inhibition of Vasopressin Neurons  Journal Articles
• Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice  Journal Articles
• Identification of Myopia-Related Marker Proteins in Tilapia Retinal, RPE, and Choroidal Tissue following Induced Form Deprivation  Journal Articles
• Identification of periplakin as a major regulator of lung injury and repair in mice  Journal Articles
• Impact of blood pressure lowering, cholesterol lowering and their combination in Asians and non-Asians in those without cardiovascular disease: an analysis of the HOPE 3 study  Journal Articles
• Inability of Human Induced Pluripotent Stem Cell-Hematopoietic Derivatives to Downregulate MicroRNAs In Vivo Reveals a Block in Xenograft Hematopoietic Regeneration  Journal Articles
• Increased proliferation of hepatic periportal ductal progenitor cells contributes to persistent hypermetabolism after trauma  Journal Articles
• Increased pro–nerve growth factor and decreased brain-derived neurotrophic factor in non–Alzheimer's disease tauopathies  Journal Articles
• Infectious salmon anaemia virus (ISAV) isolates induce distinct gene expression responses in the Atlantic salmon (Salmo salar) macrophage/dendritic-like cell line TO, assessed using genomic techniques  Journal Articles
• Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis  Journal Articles
• Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin  Journal Articles
• Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra  Journal Articles
• Interleukin-10 and nerve growth factor have reciprocal upregulatory effects on intestinal epithelial cells  Journal Articles
• Limb Immobilization Induces a Coordinate Down-Regulation of Mitochondrial and Other Metabolic Pathways in Men and Women  Journal Articles
• Live Lactobacillus reuteri Is Essential for the Inhibitory Effect on Tumor Necrosis Factor Alpha-Induced Interleukin-8 Expression  Journal Articles
• Long-lasting conditioning of the human soleus H reflex following quadriceps tendon tap  Journal Articles
• Low intensity training decreases markers of oxidative stress in skeletal muscle of mdx mice  Journal Articles
• MYC Is Activated by USP2a-Mediated Modulation of MicroRNAs in Prostate Cancer  Journal Articles
• Markedly decreased expression of TAP1 and LMP2 genes in HLA class I-deficient human tumor cell lines  Journal Articles
• Matrix Metalloproteinase-19 Promotes Metastatic BehaviorIn Vitroand Is Associated with Increased Mortality in Non–Small Cell Lung Cancer  Journal Articles
• Menin Is a Regulator of the Stress Response in Drosophila melanogaster  Journal Articles
• Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK  Journal Articles
• MicroRNA-mediated PTEN downregulation as a novel non-genetic mechanism of acquired resistance to PI3Kα inhibitors of head & neck squamous cell carcinoma.  Journal Articles
• Modular pharmacology-based approach to identify hub genes and kernel pathways of taodan granules treated psoriasis  Journal Articles
• Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis  Journal Articles
• Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells  Journal Articles
• Mutant p53 Enhances Nuclear Factor κB Activation by Tumor Necrosis Factor α in Cancer Cells  Journal Articles
• Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts  Journal Articles
• NT-3 modulates BDNF and proBDNF levels in naïve and kindled rat hippocampus  Journal Articles
• Na⁺,K⁺‐ATPase concentration and fiber type distribution after spinal cord injury  Journal Articles
• Neurofibrillary Tangles and Senile Plaques in Alzheimers Brains are Associated with Reduced Capillary Expression of Vascular Endothelial Growth Factor and Endothelial Nitric Oxide Synthase  Journal Articles
• Object recognition memory and BDNF expression are reduced in young TgCRND8 mice  Journal Articles
• Oligomeric Amyloid Decreases Basal Levels of Brain-Derived Neurotrophic factor (BDNF) mRNA via Specific Downregulation of BDNF Transcripts IV and V in Differentiated Human Neuroblastoma Cells  Journal Articles
• Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation  Journal Articles
• Overexpression of MyoD-inducible lysosomal sialidase (neu1) inhibits myogenesis in C2C12 cells  Journal Articles
• Overexpression of the Endoplasmic Reticulum 60 Protein ER-60 Downregulates ApoB100 Secretion by Inducing Its Intracellular Degradation via a Nonproteasomal Pathway:  Evidence for an ER-60-Mediated and pCMB-Sensitive Intracellular Degradative Pathway  Journal Articles
• Oxidative stress contributes to the induction and persistence of TGF-β1 induced pulmonary fibrosis  Journal Articles
• PGC‐1α gene expression is down‐regulated by Akt‐mediated phosphorylation and nuclear exclusion of FoxO1 in insulin‐stimulated skeletal muscle  Journal Articles
• Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo  Journal Articles
• Peripheral Blood Gene Expression Changes during Allergen Inhalation Challenge in Atopic Asthmatic Individuals  Journal Articles
• Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9  Journal Articles
• Polymorphism of the beta2-adrenoceptor and the response to long-term beta2-agonist therapy in asthma  Journal Articles
• Pre-exposure to Waterborne Nickel Downregulates Gastrointestinal Nickel Uptake in Rainbow Trout: Indirect Evidence for Nickel Essentiality  Journal Articles
• Precursor form of brain‐derived neurotrophic factor and mature brain‐derived neurotrophic factor are decreased in the pre‐clinical stages of Alzheimer's disease  Journal Articles
• Preneoplastic changes persist after IGF-IR downregulation and tumor regression  Journal Articles
• Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer’s disease  Journal Articles
• Prognostic Implications of the Immunohistochemical Expression of Human Kallikreins 5, 6, 10 and 11 in Renal Cell Carcinoma  Journal Articles
• Progressive Transforming Growth Factor β1–induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor  Journal Articles
• Proteomic analysis of common bean seed with storage protein deficiency reveals up-regulation of sulfur-rich proteins and starch and raffinose metabolic enzymes, and down-regulation of the secretory pathway  Conferences
• Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma  Journal Articles
• Reduced resting skeletal muscle protein synthesis is rescued by resistance exercise and protein ingestion following short-term energy deficit  Journal Articles
• Regulation of the adaptor molecule LAT2, an in vivo target gene of AML1/ETO (RUNX1/RUNX1T1), during myeloid differentiation  Journal Articles
• Renal tubular angiogenic dysregulation in anti-Thy1.1 glomerulonephritis  Journal Articles
• Response of oxidative stress transcripts in the brain of wild yellow perch (Perca flavescens) exposed to an environmental gradient of methylmercury  Journal Articles
• Saffron Pre-Treatment Promotes Reduction in Tissue Inflammatory Profiles and Alters Microbiome Composition in Experimental Colitis Mice  Journal Articles
• Self‐adjoint sensitivity analysis of lossy dielectric structures with electromagnetic time‐domain simulators  Journal Articles
• Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis  Journal Articles
• Serological tests for celiac disease as indicators of long-term compliance with the gluten-free diet  Journal Articles
• Serotonin Activates Dendritic Cell Function in the Context of Gut Inflammation  Journal Articles
• Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice  Journal Articles
• Silent but deadly: IS200 promotes pathogenicity in Salmonella Typhimurium  Journal Articles
• Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation  Journal Articles
• Specific Reduction of Fas-Associated Protein with Death Domain (FADD) in Clear Cell Renal Cell Carcinoma  Journal Articles
• Specific attenuation of protein kinase phosphorylation in muscle with a high mitochondrial content  Journal Articles
• State-of-the-Art-Review : Statins Induce Hypothrombotic States?  Journal Articles
• Statins and Thrombin  Journal Articles
• Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion  Journal Articles
• Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4  Journal Articles
• Surfactant dysfunction during overexpression of TGF-β1 precedes profibrotic lung remodeling in vivo  Journal Articles
• T Cell Epitope Immunotherapy Induces a CD4+ T Cell Population with Regulatory Activity  Journal Articles
• TNF-α is a critical negative regulator of type 1 immune activation during intracellular bacterial infection  Journal Articles
• TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway  Journal Articles
• Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease  Journal Articles
• The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses  Journal Articles
• The Effect of Paroxetine on 5-HT_2A Receptors in Depression: An [¹⁸F]Setoperone PET Imaging Study  Journal Articles
• The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses  Journal Articles
• The NK Receptor NKp30 Mediates Direct Fungal Recognition and Killing and Is Diminished in NK Cells from HIV-Infected Patients  Journal Articles
• The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice  Journal Articles
• The Pseudomonas aeruginosa PilSR Two-Component System Regulates Both Twitching and Swimming Motilities  Journal Articles
• The YebC Family Protein PA0964 Negatively Regulates thePseudomonas aeruginosaQuinolone Signal System and Pyocyanin Production  Journal Articles
• The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the β-catenin/TCF target gene matrilysin  Journal Articles
• The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis  Journal Articles
• The obesity epidemic: the role of addiction  Journal Articles
• The pituitary gonadotropin-releasing hormone (GnRH) receptor of the female rabbit: characterization and developmental aspects  Journal Articles
• The plant signal salicylic acid shuts down expression of the vir regulon and activates quormone-quenching genes in Agrobacterium  Journal Articles
• The role of TWIST as a regulator in giant cell tumor of bone  Journal Articles
• Therapeutic levels of human Factor VIII in mice implanted with encapsulated cells: potential for gene therapy of haemophilia A  Journal Articles
• Thermal Injury Activates the eEF2K‐Dependent eEF2 Pathway in Pediatric Patients  Journal Articles
• Thiazolidinedione drugs down-regulate CXCR4 expression on human colorectal cancer cells in a peroxisome proliferator activated receptor γ-dependent manner  Journal Articles
• Time‐dependent Effect of Kainate‐induced Seizures on Glutamate Receptor GluR5, GluR6, and GluR7 mRNA and Protein Expression in Rat Hippocampus  Journal Articles
• Toxicogenomic Analysis of Mainstream Tobacco Smoke-Exposed Mice Reveals Repression of Plasminogen Activator Inhibitor-1 Gene in Heart  Journal Articles
• Transcriptional Profiling Implicates Novel Interactions between Abiotic Stress and Hormonal Responses in Thellungiella, a Close Relative of Arabidopsis    Journal Articles
• Transcriptional effects of hypoxia on fusiogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons  Journal Articles
• Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73  Journal Articles
• USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway  Journal Articles
• VX-765 ameliorates inflammation and extracellular matrix accumulation by inhibiting the NOX1/ROS/NF-κB pathway in diabetic nephropathy  Journal Articles
• cAMP response element–binding protein is expressed at high levels in human ovarian adenocarcinoma and regulates ovarian tumor cell proliferation  Journal Articles
• miR-1297 is frequently downmodulated in flat epithelial atypia of the breast and promotes mammary neoplastic transformation via EphrinA2 regulation.  Journal Articles
• miR‐10b*, a master inhibitor of the cell cycle, is down‐regulated in human breast tumours  Journal Articles