Down-Regulation Concept

subject area of

• 15-Deoxy-Δ12,14-prostaglandin J2 down-regulates CXCR4 on carcinoma cells through PPARγ- and NFκB-mediated pathways  Academic Article
• 4-Phenylbutyrate Inhibits Tunicamycin-Induced Acute Kidney Injury via CHOP/GADD153 Repression  Academic Article
• A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion  Academic Article
• ADAMTS-13 metalloprotease abnormalities in systemic lupus erythematosus: is there a correlation with disease status?  Academic Article
• AMP-Activated Protein Kinase Is Not Down-Regulated in Human Skeletal Muscle of Obese Females  Academic Article
• Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathway  Academic Article
• Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction.  Academic Article
• Adenovirus-Mediated Gene Transfer of TGF-β1 to the Renal Glomeruli Leads to Proteinuria  Academic Article
• Adenylyl Cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice  Academic Article
• Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines  Academic Article
• Anti-sRAGE autoimmunity in obesity: Downturn after bariatric surgery is independent of previous diabetic status  Academic Article
• Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells  Academic Article
• Apatorsen plus docetaxel versus docetaxel alone in platinum-resistant metastatic urothelial carcinoma (Borealis-2)  Academic Article
• Aromatase Inhibitor Exemestane has Antiproliferative Effects on Human Mesothelioma Cells  Academic Article
• Assessment of the cardioprotective effect of liraglutide on methotrexate induced cardiac dysfunction through suppression of inflammation and enhancement of angiogenesis in rats.  Academic Article
• Bifidobacterium infantis NLS Super Strain Reduces the Expression of α-Defensin-5, a Marker of Innate Immunity, in the Mucosa of Active Celiac Disease Patients  Academic Article
• Butein impairs the protumorigenic activity of malignant pleural mesothelioma cells  Academic Article
• CREB expression mediates amyloid β-induced basal BDNF downregulation  Academic Article
• Carnosine, taurine and enzyme activities of human skeletal muscle fibres from elderly subjects with osteoarthritis and young moderately active subjects  Academic Article
• Changes in parvalbumin immunoreactive retinal ganglion cells and amacrine cells after optic nerve injury  Academic Article
• Chronic β₂-adrenoceptor stimulation impairs cardiac relaxation via reduced SR Ca²⁺-ATPase protein and activity  Academic Article
• Cigarette Smoke Exposure Leads to Follicle Loss via an Alternative Ovarian Cell Death Pathway in a Mouse Model  Academic Article
• Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis inSmad3knockout mice  Academic Article
• Cl⁻transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na⁺channels (ENaCs) inXenopusoocytes co-expressing CFTR and ENaC  Academic Article
• Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway  Academic Article
• Conditional Deletion of AP-2β in the Periocular Mesenchyme of Mice Alters Corneal Epithelial Cell Fate and Stratification  Academic Article
• Contactin-1 Reduces E-Cadherin Expression Via Activating AKT in Lung Cancer  Academic Article
• Critical Negative Regulation of Type 1 T Cell Immunity and Immunopathology by Signaling Adaptor DAP12 during Intracellular Infection  Academic Article
• Dabigatran etexilate and reduction in serum apolipoprotein B  Academic Article
• Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease  Academic Article
• Decreased Expression of Cerebral Dopamine Neurotrophic Factor in Platelets of Stroke Patients  Academic Article
• Desensitization of D1 dopamine receptors down-regulates the Gsα subunit of G protein in SK-N-MC neuroblastoma cells  Academic Article
• Development of the embryonic heat shock response and the impact of repeated thermal stress in early stage lake whitefish ( Coregonus clupeaformis ) embryos  Academic Article
• Differential mechanisms of posterior cingulate cortex downregulation and symptom decreases in posttraumatic stress disorder and healthy individuals using real‐time fMRI neurofeedback  Academic Article
• Differential proteomic analysis of renal tissue in mesangial proliferative glomerulonephritis using iTRAQ technology  Academic Article
• Differential regulation of striatal G protein levels following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration in C57 BL/6 mice  Academic Article
• Discovery of Novel Hypermethylated Genes in Prostate Cancer Using Genomic CpG Island Microarrays  Academic Article
• Dopamine sudden depletion as a model for mixed depression  Academic Article
• Dosing regimen differentiates sensitization of locomotion and mouthing to D2 agonist quinpirole  Academic Article
• Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system  Academic Article
• Downregulation of BM88 After Optic Nerve Injury  Academic Article
• Downregulation of Na⁺-K⁺-ATPase pumps in skeletal muscle with training in normobaric hypoxia  Academic Article
• Downregulation of microRNAs 145-3p and 145-5p Is a Long-term Predictor of Postmenopausal Breast Cancer Risk: The ORDET Prospective Study  Academic Article
• Effect of contact lens material on cytotoxicity potential of multipurpose solutions using human corneal epithelial cells.  Academic Article
• Effect of loxapine on peripheral dopamine-like and serotonin receptors in patients with schizophrenia.  Academic Article
• Effects of Electroconvulsive Therapy on Peripheral Adrenoceptors, Plasma, Noradrenaline, MHPG and Cortisol in Depressed Patients  Academic Article
• Endogenous protein C activation in patients with severe sepsis  Academic Article
• Epigenetic silencing of miR-145-5p contributes to brain metastasis  Academic Article
• Epigenetic therapy inhibits metastases by disrupting premetastatic niches  Academic Article
• Ethylenecarbodiimide-fixed splenocytes carrying whole islet antigens decrease the incidence of diabetes in NOD mice <i>via</i> down-regulation of effector memory T cells and autoantibodies  Academic Article
• Evidence that Herpes Simplex Virus VP16 Is Required for Viral Egress Downstream of the Initial Envelopment Event  Academic Article
• Expression of the 1,25-dihydroxyvitamin D3-24-hydroxylase gene in rat intestine: Response to calcium, vitamin D3 and calcitriol administration in vivo  Academic Article
• Extracellular Matrix and Fibrocyte Accumulation in BALB/c Mouse Lung upon Transient Overexpression of Oncostatin M  Academic Article
• FGF-Regulated Etv Genes Are Essential for Repressing Shh Expression in Mouse Limb Buds  Academic Article
• Functional Expression of Neurokinin 1 Receptors on Mast Cells Induced by IL-4 and Stem Cell Factor  Academic Article
• Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic β-cells  Academic Article
• Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression  Academic Article
• Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells  Academic Article
• Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins  Academic Article
• Gene expression endpoints following chronic waterborne copper exposure in a genomic model organism, the zebrafish, Danio rerio  Academic Article
• Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis  Academic Article
• Glucosamine-Induced Endoplasmic Reticulum Stress Promotes ApoB100 Degradation  Academic Article
• HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions  Academic Article
• Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5  Academic Article
• High Salt Intake Increases Blood Pressure via BDNF-Mediated Downregulation of KCC2 and Impaired Baroreflex Inhibition of Vasopressin Neurons  Academic Article
• Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice  Academic Article
• Identification of Myopia-Related Marker Proteins in Tilapia Retinal, RPE, and Choroidal Tissue following Induced Form Deprivation  Academic Article
• Identification of periplakin as a major regulator of lung injury and repair in mice  Academic Article
• Impact of blood pressure lowering, cholesterol lowering and their combination in Asians and non-Asians in those without cardiovascular disease: an analysis of the HOPE 3 study  Academic Article
• Inability of Human Induced Pluripotent Stem Cell-Hematopoietic Derivatives to Downregulate MicroRNAs In Vivo Reveals a Block in Xenograft Hematopoietic Regeneration  Academic Article
• Increased pro–nerve growth factor and decreased brain-derived neurotrophic factor in non–Alzheimer's disease tauopathies  Academic Article
• Infectious salmon anaemia virus (ISAV) isolates induce distinct gene expression responses in the Atlantic salmon (Salmo salar) macrophage/dendritic-like cell line TO, assessed using genomic techniques  Academic Article
• Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis  Academic Article
• Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin  Academic Article
• Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra  Academic Article
• Interleukin-10 and nerve growth factor have reciprocal upregulatory effects on intestinal epithelial cells  Academic Article
• Limb Immobilization Induces a Coordinate Down-Regulation of Mitochondrial and Other Metabolic Pathways in Men and Women  Academic Article
• Live Lactobacillus reuteri Is Essential for the Inhibitory Effect on Tumor Necrosis Factor Alpha-Induced Interleukin-8 Expression  Academic Article
• Long-lasting conditioning of the human soleus H reflex following quadriceps tendon tap  Academic Article
• Low intensity training decreases markers of oxidative stress in skeletal muscle of mdx mice  Academic Article
• MYC Is Activated by USP2a-Mediated Modulation of MicroRNAs in Prostate Cancer  Academic Article
• Markedly decreased expression of TAP1 and LMP2 genes in HLA class I-deficient human tumor cell lines  Academic Article
• Matrix Metalloproteinase-19 Promotes Metastatic Behavior In Vitro and Is Associated with Increased Mortality in Non–Small Cell Lung Cancer  Academic Article
• Menin Is a Regulator of the Stress Response in Drosophila melanogaster  Academic Article
• Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK  Academic Article
• Modular pharmacology-based approach to identify hub genes and kernel pathways of taodan granules treated psoriasis  Academic Article
• Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis  Academic Article
• Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15  Academic Article
• Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells  Academic Article
• Mutant p53 Enhances Nuclear Factor κB Activation by Tumor Necrosis Factor α in Cancer Cells  Academic Article
• Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts  Academic Article
• NT-3 modulates BDNF and proBDNF levels in naïve and kindled rat hippocampus  Academic Article
• Na+,K+-ATPase concentration and fiber type distribution after spinal cord injury  Academic Article
• Neurofibrillary Tangles and Senile Plaques in Alzheimers Brains are Associated with Reduced Capillary Expression of Vascular Endothelial Growth Factor and Endothelial Nitric Oxide Synthase  Academic Article
• Object recognition memory and BDNF expression are reduced in young TgCRND8 mice  Academic Article
• Oestrogen receptor downregulation: an opportunity for extending the window of endocrine therapy in advanced breast cancer  Academic Article
• Oligomeric Amyloid Decreases Basal Levels of Brain-Derived Neurotrophic factor (BDNF) mRNA via Specific Downregulation of BDNF Transcripts IV and V in Differentiated Human Neuroblastoma Cells  Academic Article
• Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation  Academic Article
• Overexpression of MyoD-inducible lysosomal sialidase (neu1) inhibits myogenesis in C2C12 cells  Academic Article
• Overexpression of the Endoplasmic Reticulum 60 Protein ER-60 Downregulates ApoB100 Secretion by Inducing Its Intracellular Degradation via a Nonproteasomal Pathway:  Evidence for an ER-60-Mediated and pCMB-Sensitive Intracellular Degradative Pathway  Academic Article
• Oxidative stress contributes to the induction and persistence of TGF-β1 induced pulmonary fibrosis  Academic Article
• PGC‐1α gene expression is down‐regulated by Akt‐mediated phosphorylation and nuclear exclusion of FoxO1 in insulin‐stimulated skeletal muscle  Academic Article
• Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo  Academic Article
• Perinatal Phenotype and Hypothyroidism Are Associated with Elevated Levels of 21.5- to 22-kDa Basic Fibroblast Growth Factor in Cardiac Ventricles  Academic Article
• Peripheral Blood Gene Expression Changes during Allergen Inhalation Challenge in Atopic Asthmatic Individuals  Academic Article
• Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9  Academic Article
• Phosphorylation of mitochondrial phospholipid scramblase 3 by protein kinase C-δ induces its activation and facilitates mitochondrial targeting of tBid  Academic Article
• Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis  Academic Article
• Polymorphism of the beta2-adrenoceptor and the response to long-term beta2-agonist therapy in asthma.  Academic Article
• Pre-exposure to Waterborne Nickel Downregulates Gastrointestinal Nickel Uptake in Rainbow Trout: Indirect Evidence for Nickel Essentiality  Academic Article
• Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease  Academic Article
• Preneoplastic changes persist after IGF-IR downregulation and tumor regression  Academic Article
• Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer’s disease  Academic Article
• Prognostic Implications of the Immunohistochemical Expression of Human Kallikreins 5, 6, 10 and 11 in Renal Cell Carcinoma  Academic Article
• Progressive Transforming Growth Factor β1–induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor  Academic Article
• Proteomic analysis of common bean seed with storage protein deficiency reveals up-regulation of sulfur-rich proteins and starch and raffinose metabolic enzymes, and down-regulation of the secretory pathway  Conference Paper
• Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma  Academic Article
• Reduced resting skeletal muscle protein synthesis is rescued by resistance exercise and protein ingestion following short-term energy deficit  Academic Article
• Regulation of the adaptor molecule LAT2, an in vivo target gene of AML1/ETO (RUNX1/RUNX1T1), during myeloid differentiation  Academic Article
• Renal tubular angiogenic dysregulation in anti-Thy1.1 glomerulonephritis  Academic Article
• Response of oxidative stress transcripts in the brain of wild yellow perch (Perca flavescens) exposed to an environmental gradient of methylmercury  Academic Article
• Saffron Pre-Treatment Promotes Reduction in Tissue Inflammatory Profiles and Alters Microbiome Composition in Experimental Colitis Mice  Academic Article
• Self-adjoint sensitivity analysis of lossy dielectric structures with electromagnetic time-domain simulators  Academic Article
• Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis  Academic Article
• Serological tests for celiac disease as indicators of long-term compliance with the gluten-free diet  Academic Article
• Serotonin Activates Dendritic Cell Function in the Context of Gut Inflammation  Academic Article
• Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice  Academic Article
• Silent but deadly: IS200 promotes pathogenicity in Salmonella Typhimurium  Academic Article
• Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation  Academic Article
• Specific Reduction of Fas-Associated Protein with Death Domain (FADD) in Clear Cell Renal Cell Carcinoma  Academic Article
• Specific attenuation of protein kinase phosphorylation in muscle with a high mitochondrial content  Academic Article
• State-of-the-Art-Review : Statins Induce Hypothrombotic States?  Academic Article
• Statins and Thrombin  Academic Article
• Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion  Academic Article
• Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4  Academic Article
• Surfactant dysfunction during overexpression of TGF-β1 precedes profibrotic lung remodeling in vivo  Academic Article
• T Cell Epitope Immunotherapy Induces a CD4+ T Cell Population with Regulatory Activity  Academic Article
• T cells and the immune response: down-regulation via mucosal exposure.  Academic Article
• TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state  Academic Article
• TNF-α is a critical negative regulator of type 1 immune activation during intracellular bacterial infection  Academic Article
• TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway  Academic Article
• Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease  Academic Article
• The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses  Academic Article
• The Effect of Paroxetine on 5-HT_2AReceptors in Depression: An [¹⁸F]Setoperone PET Imaging Study  Academic Article
• The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses  Academic Article
• The NK Receptor NKp30 Mediates Direct Fungal Recognition and Killing and Is Diminished in NK Cells from HIV-Infected Patients  Academic Article
• The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice  Academic Article
• The Pseudomonas aeruginosa PilSR Two-Component System Regulates Both Twitching and Swimming Motilities  Academic Article
• The YebC Family Protein PA0964 Negatively Regulates the Pseudomonas aeruginosa Quinolone Signal System and Pyocyanin Production  Academic Article
• The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the β-catenin/TCF target gene matrilysin  Academic Article
• The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis  Academic Article
• The obesity epidemic: the role of addiction  Academic Article
• The pituitary gonadotropin-releasing hormone (GnRH) receptor of the female rabbit: characterization and developmental aspects  Academic Article
• The plant signal salicylic acid shuts down expression of the vir regulon and activates quormone-quenching genes in Agrobacterium  Academic Article
• The role of TWIST as a regulator in giant cell tumor of bone  Academic Article
• Therapeutic levels of human Factor VIII in mice implanted with encapsulated cells: potential for gene therapy of haemophilia A  Academic Article
• Thiazolidinedione drugs down-regulate CXCR4 expression on human colorectal cancer cells in a peroxisome proliferator activated receptor γ-dependent manner  Academic Article
• Time-dependent Effect of Kainate-induced Seizures on Glutamate Receptor GluR5, GluR6, and GluR7 mRNA and Protein Expression in Rat Hippocampus  Academic Article
• Toxicogenomic Analysis of Mainstream Tobacco Smoke-Exposed Mice Reveals Repression of Plasminogen Activator Inhibitor-1 Gene in Heart  Academic Article
• Transcriptional Profiling Implicates Novel Interactions between Abiotic Stress and Hormonal Responses in Thellungiella, a Close Relative of Arabidopsis    Academic Article
• Transcriptional effects of hypoxia on fusiogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons  Academic Article
• Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73  Academic Article
• USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway  Academic Article
• cAMP response element–binding protein is expressed at high levels in human ovarian adenocarcinoma and regulates ovarian tumor cell proliferation  Academic Article
• miR‐10b*, a master inhibitor of the cell cycle, is down‐regulated in human breast tumours  Academic Article