Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis Journal Articles

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abstract

Key PointsTransient inhibition of hedgehog signaling augments hematopoiesis in hPSC-derived EBs. Hedgehog inhibition initiates an advancement in the developmental state of hematopoietic cells derived from hPSCs.

authors

McIntyre, Brendan AS
Ramos-Mejia, Veronica
Rampalli, Shravanti
Mechael, Rami
Lee, Jong-Hee
Alev, Cantas
Sheng, Guojun
Bhatia, Mick

status

published

publication date

February 28, 2013

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Adult (MeSH)
Adult Stem Cells (MeSH)
Blood Cells (MeSH)
Cell Differentiation (MeSH)
Cells, Cultured (MeSH)
Down-Regulation (MeSH)
Gene Expression Regulation, Developmental (MeSH)
Hedgehog Proteins (MeSH)
Hematopoiesis (MeSH)
Hematopoietic Stem Cells (MeSH)
Humans (MeSH)
Immunology (Science Metrix)
Kruppel-Like Transcription Factors (MeSH)
Microarray Analysis (MeSH)
Nerve Tissue Proteins (MeSH)
Pluripotent Stem Cells (MeSH)
Signal Transduction (MeSH)
Transcriptome (MeSH)
Zinc Finger Protein Gli3 (MeSH)

published in

Blood Journal