Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis Academic Article uri icon

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abstract

  • Key Points Transient inhibition of hedgehog signaling augments hematopoiesis in hPSC-derived EBs. Hedgehog inhibition initiates an advancement in the developmental state of hematopoietic cells derived from hPSCs.

authors

  • McIntyre, Brendan AS
  • Ramos-Mejia, Veronica
  • Rampalli, Shravanti
  • Mechael, Rami
  • Lee, Jong-Hee
  • Alev, Cantas
  • Sheng, Guojun
  • Bhatia, Mick

publication date

  • February 28, 2013

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