Journal article
The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the β-catenin/TCF target gene matrilysin
Abstract
The POZ-zinc finger transcription factor Kaiso was first identified as a specific binding partner for the Armadillo catenin and cell adhesion cofactor, p120ctn. Kaiso is a unique POZ protein with bi-modal DNA-binding properties; it associates with a sequence-specific DNA consensus Kaiso binding site (KBS) or methylated CpG dinucleotides, and regulates transcription of artificial promoters containing either site. Interestingly, the promoter of …
Authors
Spring CM; Kelly KF; O'Kelly I; Graham M; Crawford HC; Daniel JM
Journal
Experimental Cell Research, Vol. 305, No. 2, pp. 253–265
Publisher
Elsevier
Publication Date
May 2005
DOI
10.1016/j.yexcr.2005.01.007
ISSN
0014-4827
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBase SequenceCateninsCell Adhesion MoleculesChromatin ImmunoprecipitationCytoskeletal ProteinsDown-RegulationGene Expression RegulationHumansMatrix Metalloproteinase 7MiceMolecular Sequence DataPhosphoproteinsPromoter Regions, GeneticRNA InterferenceRepressor ProteinsTrans-ActivatorsTranscription FactorsTranscription, Geneticbeta CateninDelta Catenin