Home
Scholarly Works
Musashi-2 attenuates AHR signalling to expand...
Journal article

Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells

Abstract

The RNA-binding protein Musashi-2 increases the self-renewing abilities of human haematopoietic stem cells, which have the potential to be used for regenerative therapies.

Authors

Rentas S; Holzapfel NT; Belew MS; Pratt GA; Voisin V; Wilhelm BT; Bader GD; Yeo GW; Hope KJ

Journal

Nature, Vol. 532, No. 7600, pp. 508–511

Publisher

Springer Nature

Publication Date

April 27, 2016

DOI

10.1038/nature17665

ISSN

0028-0836

Associated Experts

Kristin Hope

Associate Professor (Part-Time), Faculty of Health Sciences
Visit profile

Labels

Fields of Research (FoR)

3206 Medical Biotechnology32 Biomedical and Clinical Sciences

Medical Subject Headings (MeSH)

AnimalsBase SequenceBasic Helix-Loop-Helix Transcription FactorsCell CountCell Self RenewalDown-RegulationFemaleFetal BloodGene Knockdown TechniquesHematopoietic Stem CellsHumansMaleMiceProtein BindingRNA, MessengerRNA-Binding ProteinsReceptors, Aryl HydrocarbonSignal Transduction
View published work (Non-McMaster Users)
View published work (McMaster Users)

Contact the Experts team

Get technical help
or
Provide website feedback