Journal article
Aromatase Inhibitor Exemestane has Antiproliferative Effects on Human Mesothelioma Cells
Abstract
PURPOSE: The aim of this study was to investigate the expression and biological activity of aromatase (CYP19A1) in malignant mesothelioma (MM).
EXPERIMENTAL DESIGN: We found CYP19A1 in five human MM cell lines using reverse transcription polymerase chain reaction and Western immunoblots and in a group of samples from patients with MM by immunohistochemistry. Aromatization activity was determined in MM cells by enzyme-linked immunosorbent assay …
Authors
Stoppoloni D; Salvatori L; Biroccio A; D'Angelo C; Muti P; Verdina A; Sacchi A; Vincenzi B; Baldi A; Galati R
Journal
Journal of Thoracic Oncology, Vol. 6, No. 3, pp. 583–591
Publisher
Elsevier
Publication Date
March 2011
DOI
10.1097/jto.0b013e31820cdd6f
ISSN
1556-0864
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AndrostadienesAromataseAromatase InhibitorsBlotting, WesternBreast NeoplasmsCell CycleCell ProliferationDown-RegulationEnzyme-Linked Immunosorbent AssayFlow CytometryFollow-Up StudiesHumansImmunoenzyme TechniquesMesotheliomaPrognosisRNA, MessengerReceptors, EstrogenRetrospective StudiesReverse Transcriptase Polymerase Chain ReactionSurvival RateTumor Cells, Cultured