Journal article
Desensitization of D1 dopamine receptors down-regulates the Gsα subunit of G protein in SK-N-MC neuroblastoma cells
Abstract
The effect of long-term (72 h) treatment with dopamine D1 receptor agonists, SKF 38393 and dopamine on D1 dopamine receptor and G-protein (GSα) was investigated in SK-N-MC neuroblastoma cells. The prolonged treatment of cells with 10 μM SKF 38393 or 10 μM dopamine resulted in a decrease in dopamine D1 receptor by 41 and 81%, respectively, as measured by specific antagonist [3H]SCH 23390 binding. Similary, the prolonged treatment of SK-N-MC …
Authors
Gupta SK; Mishra RK
Journal
Journal of Molecular Neuroscience, Vol. 4, No. 2, pp. 117–123
Publisher
Springer Nature
Publication Date
June 1993
DOI
10.1007/bf02782124
ISSN
0895-8696