Journal article
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Abstract
BackgroundWe characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9.MethodsPublished and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results …
Authors
Schmidt AF; Holmes MV; Preiss D; Swerdlow DI; Denaxas S; Fatemifar G; Faraway R; Finan C; Valentine D; Fairhurst-Hunter Z
Journal
BMC Cardiovascular Disorders, Vol. 19, No. 1,
Publisher
Springer Nature
Publication Date
December 2019
DOI
10.1186/s12872-019-1187-z
ISSN
1471-2261
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Anticholesteremic AgentsBiomarkersBrain IschemiaCholesterol, LDLDown-RegulationDyslipidemiasGenome-Wide Association StudyHumansMyocardial InfarctionPCSK9 InhibitorsPolymorphism, Single NucleotideProprotein Convertase 9Randomized Controlled Trials as TopicRisk AssessmentRisk FactorsSerine Proteinase InhibitorsStrokeTreatment Outcome