Journal article
Glucosamine-Induced Endoplasmic Reticulum Stress Promotes ApoB100 Degradation
Abstract
OBJECTIVE: To investigate the role of glucosamine-mediated endoplasmic reticulum (ER) stress and Grp78 (BiP) in the intracellular degradation of apolipoprotein B100 (apoB100) in cultured hepatocytes.
METHODS AND RESULTS: Glucosamine treatment (2.5 to 10 mmol/L) of HepG2 cells increased levels of the ER chaperones, 78-kDa glucose-regulated protein (Grp78) and Grp94, in a dose-dependent manner and led to significant decreases in both cellular and …
Authors
Qiu W; Kohen-Avramoglu R; Mhapsekar S; Tsai J; Austin RC; Adeli K
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 25, No. 3, pp. 571–577
Publisher
Wolters Kluwer
Publication Date
March 2005
DOI
10.1161/01.atv.0000154142.61859.94
ISSN
1079-5642
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAnimalsApolipoprotein B-100Apolipoproteins BCarcinoma, HepatocellularCell Line, TumorCricetinaeCysteine Proteinase InhibitorsDown-RegulationEndoplasmic ReticulumEndoplasmic Reticulum Chaperone BiPGene ExpressionGlucosamineHeat-Shock ProteinsHepatocytesHumansLactonesLiver NeoplasmsMembrane GlycoproteinsMolecular ChaperonesProteasome Endopeptidase ComplexProteasome InhibitorsRatsTrypsinUbiquitin