Journal article
Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis
Abstract
BACKGROUND & AIMS: Serotonin (5-hydroxytryptamine [5-HT]) is synthesized mainly within enterochromaffin (EC) cells in the gut, and tryptophan hydroxylase 1 (Tph1) is the rate-limiting enzyme for 5-HT synthesis in EC cells. Accumulating evidence suggests the importance of gut microbiota in intestinal inflammation. Considering the close proximity of EC cells and the microbes, we investigated the influence of gut-derived 5-HT on the microbiota and …
Authors
Kwon YH; Wang H; Denou E; Ghia J-E; Rossi L; Fontes ME; Bernier SP; Shajib S; Banskota S; Collins SM
Journal
Cellular and Molecular Gastroenterology and Hepatology, Vol. 7, No. 4, pp. 709–728
Publisher
Elsevier
Publication Date
2019
DOI
10.1016/j.jcmgh.2019.01.004
ISSN
2352-345X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAnti-Bacterial AgentsBacteriaColitisColonDextran SulfateDisease SusceptibilityDown-RegulationEpithelial CellsGastrointestinal MicrobiomeGerm-Free LifeHeterozygoteInflammationIntestinal MucosaIntestinesMaleMice, Inbred C57BLPPAR gammaReceptors, SerotoninSerotoninSignal TransductionTryptophan HydroxylaseUp-Regulationbeta-Defensins