Tumor Suppressor Proteins Concept

subject area of

• A Gene Variant in CERS2 Is Associated with Rate of Increase in Albuminuria in Patients with Diabetes from ONTARGET and TRANSCEND  Academic Article
• A Role of p73 in Mitotic Exit  Academic Article
• A novel nonsense mutation in TUSC3 is responsible for non-syndromic autosomal recessive mental retardation in a consanguineous Iranian family  Academic Article
• A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients.  Academic Article
• ATM activation is accompanied with earlier stages of prostate tumorigenesis  Academic Article
• ATM activity contributes to the tumor-suppressing functions of p14ARF  Academic Article
• ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes  Academic Article
• ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence  Academic Article
• ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance  Academic Article
• Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia  Academic Article
• Activation of the Hedgehog Signaling Pathway in the Developing Lens Stimulates EctopicFoxE3Expression and Disruption in Fiber Cell Differentiation  Academic Article
• Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells  Academic Article
• Amplification of the prolactin receptor gene in mammary lobular neoplasia  Academic Article
• An RNAi Screen Identifies Msi2 and Prox1 as Having Opposite Roles in the Regulation of Hematopoietic Stem Cell Activity  Academic Article
• Analysis of p73 expression pattern in acute myeloid leukemias: lack of ΔN-p73 expression is a frequent feature of acute promyelocytic leukemia  Academic Article
• Atypical Teratoid Rhabdoid Tumors (ATRTs): The British Columbia's Children's Hospital's Experience, 1986-2006  Academic Article
• Blood flow reprograms lymphatic vessels to blood vessels  Academic Article
• Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation  Academic Article
• CYB5D2 displays tumor suppression activities towards cervical cancer  Academic Article
• Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex  Academic Article
• Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73  Academic Article
• Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation  Academic Article
• Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21WAF1/CIP1 and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity  Academic Article
• Compromised genomic integrity impedes muscle growth after Atrx inactivation  Academic Article
• Current status and future innovations of hormonal agents, chemotherapy and investigational agents in endometrial cancer  Academic Article
• DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes  Academic Article
• Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer  Academic Article
• Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas  Academic Article
• Differential Regulation of Components of the Ubiquitin-Proteasome Pathway during Lens Cell Differentiation  Academic Article
• Differential expression pattern of ZAC in developing mouse and human pancreas  Academic Article
• ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53  Academic Article
• Editorial Comment on: Metastin Inhibits Migration and Invasion of Renal Cell Carcinoma with Overexpression of Metastin Receptor  Academic Article
• Enteric neurons synthesize netrins and are essential for the development of the vagal sensory innervation of the fetal gut  Academic Article
• Expression of p27 in Residual Rectal Cancer after Preoperative Chemoradiation Predicts Long-term Outcome  Academic Article
• Expression of the β4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells  Academic Article
• Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia  Academic Article
• From p63 to p53 across p73  Academic Article
• Functional role of BAALC in leukemogenesis  Academic Article
• Gender, mutant p53 and PML: A growing “affaire” in tumor suppression and oncogenesis  Academic Article
• Guidance signalling regulates leading edge behaviour during collective cell migration of cardiac cells in Drosophila  Academic Article
• Host Cell Factor-1 Interacts with and Antagonizes Transactivation by the Cell Cycle Regulatory Factor Miz-1  Academic Article
• IQGAP2, A candidate tumour suppressor of prostate tumorigenesis  Academic Article
• Identification of Direct p73 Target Genes Combining DNA Microarray and Chromatin Immunoprecipitation Analyses  Academic Article
• Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression  Academic Article
• Integration of autologous dendritic cell-based immunotherapy in the standard of care treatment for patients with newly diagnosed glioblastoma: results of the HGG-2006 phase I/II trial  Academic Article
• Integrins Regulate Responsiveness to Slit Repellent Signals  Academic Article
• Interaction of c-Abl and p73α and their collaboration to induce apoptosis  Academic Article
• Interaction of mutant p53 with p73: A Surface Plasmon Resonance and Atomic Force Spectroscopy study  Academic Article
• Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells  Academic Article
• Laminin terminates the Netrin/DCC mediated attraction of vagal sensory axons  Academic Article
• MN1 C-terminal truncation syndrome is a novel neurodevelopmental and craniofacial disorder with partial rhombencephalosynapsis  Academic Article
• MRE11–RAD50–NBS1 and ATM function as co-mediators of TRF1 in telomere length control  Academic Article
• Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death  Academic Article
• Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation  Academic Article
• Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK  Academic Article
• Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13  Academic Article
• Monoclonal antibodies raised against Xenopus p53 interact with human p73  Academic Article
• Multicenter evaluation of an amperometric immunosensor for plasma fatty acid-binding protein:  Academic Article
• Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome  Academic Article
• Netrin/DCC-mediated attraction of vagal sensory axons to the fetal mouse gut  Academic Article
• PML has a predictive role in tumor cell permissiveness to interferon-sensitive oncolytic viruses  Academic Article
• PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop  Academic Article
• Phase II study of targeted therapy with temozolomide in acute myeloid leukaemia and high-risk myelodysplastic syndrome patients pre-screened for low O⁶-methylguanine DNA methyltransferase expression  Academic Article
• Physical Interaction with Human Tumor-derived p53 Mutants Inhibits p63 Activities  Academic Article
• Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity  Academic Article
• Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73  Academic Article
• Pin1 Links the Activities of c-Abl and p300 in Regulating p73 Function  Academic Article
• Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination  Academic Article
• Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53  Academic Article
• Regulation of the cell cycle in response to inhibition of mitochondrial generated energy  Academic Article
• Roles for MSI2 and PROX1 in hematopoietic stem cell activity  Academic Article
• S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation  Academic Article
• S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situof the breast  Academic Article
• Signal transducer and activator of transcription 3 and 5 regulate system Xc- and redox balance in human breast cancer cells  Academic Article
• TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer  Academic Article
• Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread  Academic Article
• Telomere maintenance by telomerase and by recombination can coexist in human cells  Academic Article
• The Hippo Tumor Suppressor Pathway: A Brainstorming WorkshopA report on the research meeting “The Hippo Tumor Suppressor Pathway: A Brainstorming Workshop” sponsored mainly by the Regina Elena Cancer Center and the Nicola Foundation and held in Rome, Italy, on 22 and 23 April 2009.  Academic Article
• The Prognostic Implication of the Basal-Like (Cyclin Ehigh/p27low/p53+/Glomeruloid-Microvascular-Proliferation+) Phenotype of BRCA1 -Related Breast Cancer  Academic Article
• The Transcriptional Coactivator Yes-Associated Protein Drives p73 Gene-Target Specificity in Response to DNA Damage  Academic Article
• The Transcriptional Repressor ZEB Regulates p73 Expression at the Crossroad between Proliferation and Differentiation  Academic Article
• The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer.  Academic Article
• The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs  Academic Article
• The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells  Academic Article
• Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1)  Academic Article
• Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73  Academic Article
• Tumor Suppressor in Lung Cancer (TSLC)1 Suppresses Epithelial Cell Scattering and Tubulogenesis  Academic Article
• YAP/TAZ and EZH2 synergize to impair tumor suppressor activity of TGFBR2 in non-small cell lung cancer  Academic Article
• YAP1 Meets Tumor Suppression  Academic Article
• YAP: At the crossroad between transformation and tumor suppression  Academic Article
• p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor  Academic Article
• p63 regulation by microRNAs  Academic Article
• p73 Is Regulated by Phosphorylation at the G2/M Transition  Academic Article
• p73 and p63: Why Do We Still Need Them?  Academic Article
• p73-Mediated Chemosensitivity: A Preferential Target of Oncogenic Mutant p53  Academic Article
• p73-induced apoptosis: A question of compartments and cooperation  Academic Article
• ΔN-p73 is a transcriptional target of the PML/RARα oncogene in myeloid differentiation  Academic Article
• α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells  Academic Article
• δEF1 repressor controls selectively p53 family members during differentiation  Academic Article