Tumor Suppressor Proteins Concept

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• A Gene Variant in CERS2 Is Associated with Rate of Increase in Albuminuria in Patients with Diabetes from ONTARGET and TRANSCEND  Journal Articles
• A Role of p73 in Mitotic Exit  Journal Articles
• A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients.  Journal Articles
• ATM activation is accompanied with earlier stages of prostate tumorigenesis  Journal Articles
• ATM activity contributes to the tumor-suppressing functions of p14ARF  Journal Articles
• ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes  Journal Articles
• ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence  Journal Articles
• ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance  Journal Articles
• Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia  Journal Articles
• Activation of the Hedgehog Signaling Pathway in the Developing Lens Stimulates EctopicFoxE3Expression and Disruption in Fiber Cell Differentiation  Journal Articles
• Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells  Journal Articles
• Amplification of the prolactin receptor gene in mammary lobular neoplasia  Journal Articles
• An RNAi Screen Identifies Msi2 and Prox1 as Having Opposite Roles in the Regulation of Hematopoietic Stem Cell Activity  Journal Articles
• Analysis of p73 expression pattern in acute myeloid leukemias: lack of ΔN-p73 expression is a frequent feature of acute promyelocytic leukemia  Journal Articles
• Atypical Teratoid Rhabdoid Tumors (ATRTs): The British Columbia's Children's Hospital's Experience, 1986–2006  Journal Articles
• Blood flow reprograms lymphatic vessels to blood vessels  Journal Articles
• Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation  Journal Articles
• CYB5D2 displays tumor suppression activities towards cervical cancer  Journal Articles
• Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex  Journal Articles
• Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73  Journal Articles
• Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation  Journal Articles
• Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21WAF1/CIP1 and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity  Journal Articles
• Compromised genomic integrity impedes muscle growth after Atrx inactivation  Journal Articles
• Current status and future innovations of hormonal agents, chemotherapy and investigational agents in endometrial cancer  Journal Articles
• DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes  Journal Articles
• Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas  Journal Articles
• Differential Regulation of Components of the Ubiquitin-Proteasome Pathway during Lens Cell Differentiation  Journal Articles
• Differential expression pattern of ZAC in developing mouse and human pancreas  Journal Articles
• ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53  Journal Articles
• Editorial Comment on: Metastin Inhibits Migration and Invasion of Renal Cell Carcinoma with Overexpression of Metastin Receptor  Journal Articles
• Enteric neurons synthesize netrins and are essential for the development of the vagal sensory innervation of the fetal gut  Journal Articles
• Expression of p27 in Residual Rectal Cancer after Preoperative Chemoradiation Predicts Long-term Outcome  Journal Articles
• Expression of the β4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells  Journal Articles
• Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia  Journal Articles
• From p63 to p53 across p73  Journal Articles
• Functional role of BAALC in leukemogenesis  Journal Articles
• Gender, mutant p53 and PML: A growing “affaire” in tumor suppression and oncogenesis  Journal Articles
• Guidance signalling regulates leading edge behaviour during collective cell migration of cardiac cells in Drosophila  Journal Articles
• Host Cell Factor-1 Interacts with and Antagonizes Transactivation by the Cell Cycle Regulatory Factor Miz-1  Journal Articles
• IQGAP2, A candidate tumour suppressor of prostate tumorigenesis  Journal Articles
• Identification of Direct p73 Target Genes Combining DNA Microarray and Chromatin Immunoprecipitation Analyses  Journal Articles
• Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression  Journal Articles
• Integrins Regulate Responsiveness to Slit Repellent Signals  Journal Articles
• Interaction of c-Abl and p73α and their collaboration to induce apoptosis  Journal Articles
• Interaction of mutant p53 with p73: A Surface Plasmon Resonance and Atomic Force Spectroscopy study  Journal Articles
• Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells  Journal Articles
• Laminin terminates the Netrin/DCC mediated attraction of vagal sensory axons  Journal Articles
• MN1 C-terminal truncation syndrome is a novel neurodevelopmental and craniofacial disorder with partial rhombencephalosynapsis  Journal Articles
• MRE11–RAD50–NBS1 and ATM function as co-mediators of TRF1 in telomere length control  Journal Articles
• Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death  Journal Articles
• Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation  Journal Articles
• Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK  Journal Articles
• Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13  Journal Articles
• Monoclonal antibodies raised against Xenopus p53 interact with human p73  Journal Articles
• Multicenter evaluation of an amperometric immunosensor for plasma fatty acid-binding protein:  Journal Articles
• Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome  Journal Articles
• Netrin/DCC‐mediated attraction of vagal sensory axons to the fetal mouse gut  Journal Articles
• PML has a predictive role in tumor cell permissiveness to interferon-sensitive oncolytic viruses  Journal Articles
• PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop  Journal Articles
• Pathogenic Germline Variants in 10,389 Adult Cancers  Journal Articles
• Phase II study of targeted therapy with temozolomide in acute myeloid leukaemia and high‐risk myelodysplastic syndrome patients pre‐screened for low O⁶‐methylguanine DNA methyltransferase expression  Journal Articles
• Physical Interaction with Human Tumor-derived p53 Mutants Inhibits p63 Activities  Journal Articles
• Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity  Journal Articles
• Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73  Journal Articles
• Pin1 Links the Activities of c-Abl and p300 in Regulating p73 Function  Journal Articles
• Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination  Journal Articles
• Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53  Journal Articles
• Regulation of the cell cycle in response to inhibition of mitochondrial generated energy  Journal Articles
• Roles for MSI2 and PROX1 in hematopoietic stem cell activity  Journal Articles
• S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation  Journal Articles
• S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situof the breast  Journal Articles
• Signal transducer and activator of transcription 3 and 5 regulate system Xc- and redox balance in human breast cancer cells  Journal Articles
• Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread  Journal Articles
• Telomere maintenance by telomerase and by recombination can coexist in human cells  Journal Articles
• The Hippo Tumor Suppressor Pathway: A Brainstorming WorkshopA report on the research meeting “The Hippo Tumor Suppressor Pathway: A Brainstorming Workshop” sponsored mainly by the Regina Elena Cancer Center and the Nicola Foundation and held in Rome, Italy, on 22 and 23 April 2009.  Journal Articles
• The Prognostic Implication of the Basal-Like (Cyclin Ehigh/p27low/p53+/Glomeruloid-Microvascular-Proliferation+) Phenotype of BRCA1 -Related Breast Cancer  Journal Articles
• The Transcriptional Coactivator Yes-Associated Protein Drives p73 Gene-Target Specificity in Response to DNA Damage  Journal Articles
• The Transcriptional Repressor ZEB Regulates p73 Expression at the Crossroad between Proliferation and Differentiation  Journal Articles
• The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer.  Journal Articles
• The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs  Journal Articles
• The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells  Journal Articles
• Thrombospondin‐1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor‐related protein‐1 (LRP‐1)  Journal Articles
• Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73  Journal Articles
• YAP/TAZ and EZH2 synergize to impair tumor suppressor activity of TGFBR2 in non-small cell lung cancer  Journal Articles
• YAP1 Meets Tumor Suppression  Journal Articles
• YAP: At the crossroad between transformation and tumor suppression  Journal Articles
• p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor  Journal Articles
• p63 regulation by microRNAs  Journal Articles
• p73 Is Regulated by Phosphorylation at the G2/M Transition  Journal Articles
• p73 and p63: Why Do We Still Need Them?  Journal Articles
• p73-Mediated Chemosensitivity: A Preferential Target of Oncogenic Mutant p53  Journal Articles
• p73-induced apoptosis: A question of compartments and cooperation  Journal Articles
• ΔN-p73 is a transcriptional target of the PML/RARα oncogene in myeloid differentiation  Journal Articles
• α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells  Journal Articles
• δEF1 repressor controls selectively p53 family members during differentiation  Journal Articles