Journal article
Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas
Abstract
The transcription factor interferon regulatory factor 6 (IRF6) regulates craniofacial development and epidermal proliferation. We recently showed that IRF6 is a component of a regulatory feedback loop that controls the proliferative potential of epidermal cells. IRF6 is transcriptionally activated by p63 and induces its proteasome-mediated down-regulation, thereby limiting keratinocyte proliferative potential. We hypothesized that IRF6 may also …
Authors
Botti E; Spallone G; Moretti F; Marinari B; Pinetti V; Galanti S; De Meo PD; De Nicola F; Ganci F; Castrignanò T
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 33, pp. 13710–13715
Publisher
Proceedings of the National Academy of Sciences
Publication Date
August 16, 2011
DOI
10.1073/pnas.1110931108
ISSN
0027-8424