Journal article
YAP/TAZ and EZH2 synergize to impair tumor suppressor activity of TGFBR2 in non-small cell lung cancer
Abstract
Lung cancer is the leading cause of cancer-related deaths, worldwide. Non-small cell lung cancer (NSCLC) is the most prevalent lung cancer subtype. YAP and TAZ have been implicated in lung cancer by acting as transcriptional co-activators of oncogenes or as transcriptional co-repressors of tumor suppressor genes. Previously we reported that YAP and TAZ regulate microRNAs expression in NSCLC. Among the set of regulated miRNAs, the oncogenic …
Authors
Lo Sardo F; Pulito C; Sacconi A; Korita E; Sudol M; Strano S; Blandino G
Journal
Cancer Letters, Vol. 500, , pp. 51–63
Publisher
Elsevier
Publication Date
March 2021
DOI
10.1016/j.canlet.2020.11.037
ISSN
0304-3835
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
A549 CellsAdaptor Proteins, Signal TransducingCarcinogenesisCarcinoma, Non-Small-Cell LungDNA-Binding ProteinsEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsMicroRNAsMinichromosome Maintenance Complex Component 7Nuclear ProteinsReceptor, Transforming Growth Factor-beta Type IReceptor, Transforming Growth Factor-beta Type IITEA Domain Transcription FactorsTranscription FactorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTransforming Growth Factor beta1Tumor Suppressor ProteinsYAP-Signaling Proteins