Journal article
Regulation of the cell cycle in response to inhibition of mitochondrial generated energy
Abstract
Cell cycle control is regulated through the temporal action of both cyclin-dependent kinases and cyclin binding partners. Previously, we have demonstrated that low doses of oligomycin result in a cell cycle arrest of HL-60 cells in G(1) [S. Sweet, G. Singh, Accumulation of human promyelocytic leukemic (HL-60) cells at two energetic cell cycle checkpoints, Cancer Res. 55 (1995) 5164-5167]. In this study, we provide the molecular mechanisms for …
Authors
Gemin A; Sweet S; Preston TJ; Singh G
Journal
Biochemical and Biophysical Research Communications, Vol. 332, No. 4, pp. 1122–1132
Publisher
Elsevier
Publication Date
July 2005
DOI
10.1016/j.bbrc.2005.05.061
ISSN
0006-291X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenosine TriphosphateBlotting, WesternCDC2-CDC28 KinasesCell CycleCell Cycle ProteinsCentrifugationCyclin DCyclin D1Cyclin ECyclin-Dependent Kinase 2Cyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent KinasesCyclinsDNADNA-Binding ProteinsE2F Transcription FactorsG1 PhaseHL-60 CellsHumansImmunoprecipitationMitochondriaMitochondrial Proton-Translocating ATPasesModels, BiologicalOligomycinsPhosphorylationRetinoblastoma ProteinS PhaseTranscription FactorsTumor Suppressor Proteins