Journal article
The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer.
Abstract
The tumor suppressor gene in lung cancer (TSLC1) encodes a membrane glycoprotein containing extensive homology in the extracellular domain with the immunoglobulin-superfamily cell adhesion molecules. The intracellular cytoplasmic domain (CT) contains a protein 4.1 (FERM) binding motif, and a PDZ-interacting motif. Expression of TSLC1 is silenced in non-small cell lung cancer and in other cancers by promoter hypermethylation. Restoration of …
Authors
Mao X; Seidlitz E; Ghosh K; Murakami Y; Ghosh HP
Journal
Cancer Research, Vol. 63, No. 22, pp. 7979–7985
Publication Date
November 15, 2003
ISSN
0008-5472
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceAnimalsCarcinoma, Non-Small-Cell LungCell AdhesionCell Adhesion Molecule-1Cell Adhesion MoleculesCell DivisionCell MembraneDimerizationFemaleGenes, Tumor SuppressorHumansImmunoglobulinsLung NeoplasmsMembrane ProteinsMiceMice, Inbred BALB CMice, NudeMolecular Sequence DataMutationNeoplasm TransplantationProtein Structure, TertiaryProteinsSubcellular FractionsTransfectionTransplantation, HeterologousTumor Suppressor Proteins