Journal article
p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor
Abstract
The DNp73 proteins act as trans-repressors of p53 and p73-dependent transcription and exert both anti-apoptotic activity and pro-proliferative activity. DNp73s are frequently up-regulated in a variety of human cancers, including human hepatocellular carcinomas (HCCs). Increased levels of DNp73 proteins confer to HCC cells resistance to apoptosis and, irrespective to p53 status, a chemoresistant phenotype. Here, we show that interferon (IFN)α …
Authors
Testoni B; Schinzari V; Guerrieri F; Gerbal-Chaloin S; Blandino G; Levrero M
Journal
Oncogene, Vol. 30, No. 23, pp. 2670–2678
Publisher
Springer Nature
Publication Date
June 2011
DOI
10.1038/onc.2010.635
ISSN
0950-9232
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Binding SitesBlotting, WesternCell Line, TumorCells, CulturedChromatin ImmunoprecipitationColonic NeoplasmsDNA-Binding ProteinsEnhancer of Zeste Homolog 2 ProteinFemaleHep G2 CellsHepatocytesHistonesHumansInterferon-Stimulated Gene Factor 3, gamma SubunitInterferon-alphaMethylationMiddle AgedMutationNuclear ProteinsPolycomb Repressive Complex 2Promoter Regions, GeneticProtein BindingRNA InterferenceReverse Transcriptase Polymerase Chain ReactionSTAT1 Transcription FactorSTAT2 Transcription FactorTranscription FactorsTumor Protein p73Tumor Suppressor Proteins