selected scholarly activity
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academic article
- Nutrient stress is a target for new antibiotics. Trends in Microbiology. S0966-842X(23)00016-1. 2023
- A genetic platform to investigate the functions of bacterial drug efflux pumps. Nature Chemical Biology. 18:1399-1409. 2022
- Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria. ACS Infectious Diseases. 8:2187-2197. 2022
- Synthetic Genetic Interactions Reveal a Dense and Cryptic Regulatory Network of Small Noncoding RNAs in Escherichia coli. mBio. 13:e0122522. 2022
- Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant. ACS Infectious Diseases. 8:768-777. 2022
- Transparent and Highly Flexible Hierarchically Structured Polydimethylsiloxane Surfaces Suppress Bacterial Attachment and Thrombosis Under Static and Dynamic Conditions. Small. 18:2108112-2108112. 2022
- Antibacterial Activity of Metergoline Analogues: Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery. ACS Medicinal Chemistry Letters. 13:284-291. 2022
- New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance. Current Opinion in Chemical Biology. 66:102099-102099. 2022
- Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria. Cell Chemical Biology. 28:1703-1715.e11. 2021
- Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria. Journal of Medicinal Chemistry Journal of Medicinal and Pharmaceutical Chemistry. 64:13540-13550. 2021
- Phage–antibiotic combinations: a promising approach to constrain resistance evolution in bacteria. Annals of the New York Academy of Sciences. 1496:23-34. 2021
- Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis. Journal of Structural Biology Journal of Ultrastructure Research Journal of Ultrastructure Research and Molecular Structure Research. 213:107733-107733. 2021
- Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane. ACS Chemical Biology. 16:929-942. 2021
- Systems-Level Chemical Biology to Accelerate Antibiotic Drug Discovery. Accounts of Chemical Research. 54:1909-1920. 2021
- Exploring the relationship between impaired illness awareness and visuospatial inattention in patients with schizophrenia. Journal of Psychiatric Research. 136:468-473. 2021
- Physicochemical and Structural Parameters Contributing to the Antibacterial Activity and Efflux Susceptibility of Small-Molecule Inhibitors of Escherichia coli. Antimicrobial Agents and Chemotherapy. 65:e01925-e01920. 2021
- A Staphylococcus aureus clpX Mutant Used as a Unique Screening Tool to Identify Cell Wall Synthesis Inhibitors that Reverse β-Lactam Resistance in MRSA. Frontiers in Molecular Biosciences. 8:691569. 2021
- Erratum for Tong et al., “Gene Dispensability in Escherichia coli Grown in Thirty Different Carbon Environments”. mBio. 11:e02865-e02820. 2020
- Gene Dispensability in Escherichia coli Grown in Thirty Different Carbon Environments. mBio. 11:e02259-e02220. 2020
- Outer Membrane Disruption Overcomes Intrinsic, Acquired, and Spontaneous Antibiotic Resistance. mBio. 11:e01615-e01620. 2020
- Overcoming Acquired and Native Macrolide Resistance with Bicarbonate. ACS Infectious Diseases. 6:2709-2718. 2020
- Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae. Cell Reports. 32:107927-107927. 2020
- Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence. Cell Chemical Biology. 27:793-805.e7. 2020
- Potentiation of Antibiotics against Gram-Negative Bacteria by Polymyxin B Analogue SPR741 from Unique Perturbation of the Outer Membrane. ACS Infectious Diseases. 6:1405-1412. 2020
- Genetic and Chemical-Genetic Interactions Map Biogenesis and Permeability Determinants of the Outer Membrane of Escherichia coli. mBio. 11:e00161-e00120. 2020
- A Deep Learning Approach to Antibiotic Discovery. Cell. 181:475-483. 2020
- Uncovering the Hidden Antibiotic Potential of Cannabis. ACS Infectious Diseases. 6:338-346. 2020
- A Deep Learning Approach to Antibiotic Discovery. Cell. 180:688-702.e13. 2020
- A comprehensive guide to dynamic analysis of microbial gene expression using the 3D-printed PFIbox and a fluorescent reporter library. Nature Protocols. 15:575-603. 2020
- Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase. Journal of Biological Chemistry. 295:2629-2639. 2020
- Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA. Nature Chemical Biology. 16:143-149. 2020
- Flexible Hierarchical Wraps Repel Drug-Resistant Gram-Negative and Positive Bacteria. ACS Nano. 14:454-465. 2020
- Creative targeting of the Gram‐negative outer membrane in antibiotic discovery. Annals of the New York Academy of Sciences. 1459:69-85. 2020
- Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens. Nature Microbiology. 5:93-101. 2020
- A whole-cell, high-throughput hydrogenase assay to identify factors that modulate [NiFe]-hydrogenase activity. Journal of Biological Chemistry. 294:15373-15385. 2019
- A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria. PLoS Medicine Nature Methods. 16:303-306. 2019
- Drug repurposing for antimicrobial discovery. Nature Microbiology. 4:565-577. 2019
- Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria. PLoS Pathogens. 15:e1007723-e1007723. 2019
- A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium. Nature Communications. 10:197. 2019
- High-Throughput Screening for Inhibitors of Wall Teichoic Acid Biosynthesis in Staphylococcus aureus. Methods in Molecular Biology. 1954:297-308. 2019
- Broadened glycosylation patterning of heterologously produced erythromycin. Biotechnology and Bioengineering. 115:2771-2777. 2018
- Open-Source High-Throughput Phenomics of Bacterial Promoter-Reporter Strains. Cell Systems. 7:339-346.e3. 2018
- Psychiatric benefits of lithium in water supplies may be due to protection from the neurotoxicity of lead exposure. Medical Hypotheses. 115:94-102. 2018
- Meropenem potentiation of aminoglycoside activity against Pseudomonas aeruginosa: involvement of the MexXY-OprM multidrug efflux system. Journal of Antimicrobial Chemotherapy. 73:1247-1255. 2018
- Chemical-Chemical Combinations Map Uncharted Interactions in Escherichia coli under Nutrient Stress. iScience. 2:168-181. 2018
- Bicarbonate Alters Bacterial Susceptibility to Antibiotics by Targeting the Proton Motive Force. ACS Infectious Diseases. 4:382-390. 2018
- Membrane activity profiling of small molecule B. subtilis growth inhibitors utilizing novel duel-dye fluorescence assay. MedChemComm. 9:554-561. 2018
- Silent but deadly: IS200 promotes pathogenicity in Salmonella Typhimurium. RNA Biology. 15:176-181. 2018
- Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics. Nature Communications. 9:458. 2018
- Nutrient Stress Small-Molecule Screening Platform for Escherichia coli. Methods in Molecular Biology. 1787:1-18. 2018
- Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems. FEMS Microbiology Reviews. 42:81-99. 2018
- Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites. ACS Infectious Diseases. 3:955-965. 2017
- B. subtilis LytR-CpsA-Psr Enzymes Transfer Wall Teichoic Acids from Authentic Lipid-Linked Substrates to Mature Peptidoglycan In Vitro. Cell Chemical Biology. 24:1537-1546.e4. 2017
- Chemical genomics reveals mechanistic hypotheses for uncharacterized bioactive molecules in bacteria. Current Opinion in Microbiology. 39:42-47. 2017
- Bacteria Getting into Shape: Genetic Determinants of E. coli Morphology. mBio. 8:e01977-e01916. 2017
- Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance. Nature Microbiology. 2:17028. 2017
- Author Correction for Côté et al., The Genome-Wide Interaction Network of Nutrient Stress Genes in Escherichia coli. mBio. 7:e02138-e02116. 2016
- The Genome-Wide Interaction Network of Nutrient Stress Genes in Escherichia coli. mBio. 7:e01714-e01716. 2016
- A cell-based approach to characterize antimicrobial compounds through kinetic dose response. Bioorganic and Medicinal Chemistry. 24:6315-6319. 2016
- Identification of Two Phosphate Starvation-induced Wall Teichoic Acid Hydrolases Provides First Insights into the Degradative Pathway of a Key Bacterial Cell Wall Component. Journal of Biological Chemistry. 291:26066-26082. 2016
- Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance. PLoS Pathogens. 12:e1006067-e1006067. 2016
- The Genome-Wide Interaction Network of Nutrient Stress Genes in Escherichia coli (vol 7, e01714-16, 2016). mBio. 7. 2016
- Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening. Current Cancer Drug Targets. 16:818-828. 2016
- Systematic Genetic Screens Reveal the Dynamic Global Functional Organization of the Bacterial Translation Machinery. Cell Reports. 17:904-916. 2016
- A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase. ACS Infectious Diseases. 2:489-499. 2016
- A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria. Cell. 165:1493-1506. 2016
- Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component System. Antimicrobial Agents and Chemotherapy. 60:3509-3518. 2016
- Strategies for target identification of antimicrobial natural products. Natural Product Reports. 33:668-680. 2016
- Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chemical Biology. 11:864-868. 2016
- Assembly and clustering of natural antibiotics guides target identification. Nature Chemical Biology. 12:233-239. 2016
- A robust platform for chemical genomics in bacterial systems. Molecular Biology of the Cell Cell Regulation. 27:1015-1025. 2016
- Cold Stress Makes Escherichia coli Susceptible to Glycopeptide Antibiotics by Altering Outer Membrane Integrity. Cell Chemical Biology. 23:267-277. 2016
- Antibacterial drug discovery in the resistance era. Nature Nature: New biology. 529:336-343. 2016
- Chemical modulators of ribosome biogenesis as biological probes. Nature Chemical Biology. 11:924-932. 2015
- Gram-Negative Resistance. ACS Infectious Diseases. 1:507-507. 2015
- Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae. ACS Infectious Diseases. 1:533-543. 2015
- An electron transfer flavoprotein is essential for viability and its depletion causes a rod-to-sphere change in Burkholderia cenocepacia. Microbiology. 161:1909-1920. 2015
- Editorial overview: Microbial systems biology. Current Opinion in Microbiology. 27:viii-ix. 2015
- New chemical tools to probe cell wall biosynthesis in bacteria. Current Opinion in Microbiology. 27:69-77. 2015
- Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase. Proceedings of the National Academy of Sciences of the United States of America. 112:11048-11053. 2015
- Unconventional screening approaches for antibiotic discovery. Annals of the New York Academy of Sciences. 1354:54-66. 2015
- Characterization of Wall Teichoic Acid Degradation by the Bacteriophage ϕ29 Appendage Protein GP12 Using Synthetic Substrate Analogs. Journal of Biological Chemistry. 290:19133-19145. 2015
- Chemical Inhibition of Bacterial Ribosome Biogenesis Shows Efficacy in a Worm Infection Model. Antimicrobial Agents and Chemotherapy. 59:2918-2920. 2015
- Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid α-glycosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 112:E576-E585. 2015
- A Pipeline for Screening Small Molecules with Growth Inhibitory Activity against Burkholderia cenocepacia. PLoS ONE. 10:e0128587-e0128587. 2015
- A Dual Reporter System for Detecting RNA Interactions in Bacterial Cells. ChemBioChem. 15:2703-2709. 2014
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PhoR autokinase activity is controlled by an intermediate in wall teichoic acid metabolism that is sensed by the intracellularPAS domain during thePhoPR ‐mediated phosphate limitation response ofB acillus subtilis. Molecular Microbiology Microbiological Sciences. 94:1242-1259. 2014 - Rank Ordering Plate Data Facilitates Data Visualization and Normalization in High-Throughput Screening. Journal of Biomolecular Screening. 19:1314-1320. 2014
- Discovery of a small molecule that inhibits bacterial ribosome biogenesis. eLife. 3:e03574. 2014
- Discovery of Novel Cell Wall-Active Compounds Using P ywaC , a Sensitive Reporter of Cell Wall Stress, in the Model Gram-Positive Bacterium Bacillus subtilis. Antimicrobial Agents and Chemotherapy. 58:3261-3269. 2014
- Phenotypic investigations of the depletion of EngA inEscherichia coliare consistent with a role in ribosome biogenesis. FEMS Microbiology Letters. 353:26-32. 2014
- Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites. Bioorganic and Medicinal Chemistry Letters. 24:905-910. 2014
- Metal-Induced Isomerization Yields an Intracellular Chelator that Disrupts Bacterial Iron Homeostasis. Chemistry and Biology. 21:136-145. 2014
- Reconstituting poly(glycerol phosphate) wall teichoic acid biosynthesis in vitro using authentic substrates. Chemical Science. 5:3823-3823. 2014
- Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics. Japanese Journal of Antibiotics Journal of Antibiotics. 67:43-51. 2014
- Entrapment of Living Bacterial Cells in Low-Concentration Silica Materials Preserves Cell Division and Promoter Regulation. Chemistry of Materials. 25:4798-4805. 2013
- Antibiotic resistance—the need for global solutions. The Lancet Infectious Diseases. 13:1057-1098. 2013
- Exploring Intermolecular Interactions of a Substrate Binding Protein Using a Riboswitch-Based Sensor. Chemistry and Biology. 20:1502-1512. 2013
- Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation. Nature Chemical Biology. 9:796-804. 2013
- Collapsing the Proton Motive Force to Identify Synergistic Combinations against Staphylococcus aureus. Chemistry and Biology. 20:1168-1178. 2013
- A High-Throughput Screen of the GTPase Activity of Escherichia coli EngA to Find an Inhibitor of Bacterial Ribosome Biogenesis. Journal of Biomolecular Screening. 18:830-836. 2013
- Erratum to “Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA” [Bioorg. Med. Chem. Lett. 23 (2013) 2426–2431]. Bioorganic and Medicinal Chemistry Letters. 23:4469-4470. 2013
- Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA. Bioorganic and Medicinal Chemistry Letters. 23:2426-2431. 2013
- Is the GAIN Act a turning point in new antibiotic discovery?. Canadian Journal of Microbiology. 59:153-156. 2013
- Discovery of antibiotic adjuvants. Nature Biotechnology. 31:120-122. 2013
- Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams. ACS Chemical Biology. 8:226-233. 2013
- Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells. Cell. 149:1284-1297. 2012
- Cryo-electron microscopy structure of the 30S subunit in complex with the YjeQ biogenesis factor. RNA. 17:2026-2038. 2011
- Antibiotics as probes of biological complexity. Nature Chemical Biology. 7:415-423. 2011
- Studies of the Genetics, Function, and Kinetic Mechanism of TagE, the Wall Teichoic Acid Glycosyltransferase in Bacillus subtilis 168. Journal of Biological Chemistry. 286:23708-23716. 2011
- Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nature Chemical Biology. 7:348-350. 2011
- Understanding ribosome assembly: the structure of in vivo assembled immature 30S subunits revealed by cryo-electron microscopy. RNA. 17:697-709. 2011
- Cross‐species discovery of syncretic drug combinations that potentiate the antifungal fluconazole. Molecular Systems Biology. 7:499-499. 2011
- Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase. Bioorganic and Medicinal Chemistry. 18:8485-8492. 2010
- Chemical Probes of Escherichia coli Uncovered through Chemical-Chemical Interaction Profiling with Compounds of Known Biological Activity. Chemistry and Biology. 17:852-862. 2010
- An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase. Nature Biotechnology. 28:733-737. 2010
- Using a Riboswitch Sensor to Examine Coenzyme B12 Metabolism and Transport in E. coli. Chemistry and Biology. 17:756-765. 2010
- A High-throughput Pharmacoviral Approach Identifies Novel Oncolytic Virus Sensitizers. Molecular Therapy. 18:1123-1129. 2010
- A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers.. Molecular Therapy. 18:1123-1129. 2010
- Chemical Genomic Approaches to Study Model Microbes. Chemistry and Biology. 17:624-632. 2010
- Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis. Nature Structural and Molecular Biology Nature Structural Biology. 17:582-589. 2010
- Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. Nature Chemical Biology. 5:849-856. 2009
- Are essential genes really essential?. Trends in Microbiology. 17:433-438. 2009
- New screens and targets in antibacterial drug discovery. Current Opinion in Microbiology. 12:497-504. 2009
- The Wall Teichoic Acid Polymerase TagF Is Non-processive in Vitro and Amenable to Study Using Steady State Kinetic Analysis. Journal of Biological Chemistry. 284:21132-21138. 2009
- The N -Acetylmannosamine Transferase Catalyzes the First Committed Step of Teichoic Acid Assembly in Bacillus subtilis and Staphylococcus aureus. Journal of Bacteriology. 191:4030-4034. 2009
- High-Throughput Screening Identifies Novel Inhibitors of the Acetyltransferase Activity of Escherichia coli GlmU. Antimicrobial Agents and Chemotherapy. 53:2306-2311. 2009
- Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among Diverse Processes in Bacterial Cell Wall Biogenesis. Chemistry and Biology. 16:548-556. 2009
- Not as fab as we thought. Nature Nature: New biology. 458:39-40. 2009
- The ATPase activity of an ‘essential’ Bacillus subtilis enzyme, YdiB, is required for its cellular function and is modulated by oligomerization. Microbiology. 155:944-956. 2009
- Identification of a Toxic Peptide through Bidirectional Expression of Small RNAs. ChemBioChem. 10:238-241. 2009
- High-Throughput Screening of Model Bacteria. Methods in Molecular Biology. 486:13-27. 2009
- Known Bioactive Small Molecules Probe the Function of a Widely Conserved but Enigmatic Bacterial ATPase, YjeE. Chemistry and Biology. 15:1287-1295. 2008
- Ribosome biogenesis; the KsgA protein throws a methyl-mediated switch in ribosome assembly. Molecular Microbiology Microbiological Sciences. 70:1051-1053. 2008
- Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry. ChemBioChem. 9:2650-2662. 2008
- Use of CDP-Glycerol as an Alternate Acceptor for the Teichoic Acid Polymerase Reveals that Membrane Association Regulates Polymer Length. Journal of Bacteriology. 190:6940-6947. 2008
- Duplication of Teichoic Acid Biosynthetic Genes in Staphylococcus aureus Leads to Functionally Redundant Poly(Ribitol Phosphate) Polymerases. Journal of Bacteriology. 190:5642-5649. 2008
- A FACS-Based Approach to Engineering Artificial Riboswitches. ChemBioChem. 9:1906-1911. 2008
- The Wall Teichoic Acid Polymerase TagF Efficiently Synthesizes Poly(glycerol phosphate) on the TagB Product Lipid III. ChemBioChem. 9:1385-1390. 2008
- Comment: Canadian Chemical Biology Network: biochemistry back to the future / Commentaire : Réseau canadien de biologie chimique: la biochimie de retour vers le futur. Biochemistry and Cell Biology. 86:ix-xii. 2008
- Genetic Interaction Screens with Ordered Overexpression and Deletion Clone Sets Implicate the Escherichia coli GTPase YjeQ in Late Ribosome Biogenesis. Journal of Bacteriology. 190:2537-2545. 2008
- Small and lethal: searching for new antibacterial compounds with novel modes of actionThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.. Biochemistry and Cell Biology. 86:111-115. 2008
- Isolation of DNA Aptamers for CDP-Ribitol Synthase, and Characterization of Their Inhibitory and Structural Properties. ChemBioChem. 8:2052-2057. 2007
- The Amino Terminus of Bacillus subtilis TagB Possesses Separable Localization and Functional Properties. Journal of Bacteriology. 189:6816-6823. 2007
- Isolation of the rstA Gene as a Multicopy Suppressor of YjeE, an Essential ATPase of Unknown Function in Escherichia coli. Journal of Bacteriology. 189:3318-3321. 2007
- High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones. Chemistry and Biology. 14:153-164. 2007
- Inhibitors of Bacterial Cystathionine β-Lyase: Leads for New Antimicrobial Agents and Probes of Enzyme Structure and Function. Journal of Medicinal Chemistry Journal of Medicinal and Pharmaceutical Chemistry. 50:755-764. 2007
- Wall Teichoic Acid Polymers Are Dispensable for Cell Viability in Bacillus subtilis. Journal of Bacteriology. 188:8313-8316. 2006
- A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region. Journal of Medicinal Chemistry Journal of Medicinal and Pharmaceutical Chemistry. 49:6977-6986. 2006
- Cooperative and Critical Roles for Both G Domains in the GTPase Activity and Cellular Function of Ribosome-Associated Escherichia coli EngA. Journal of Bacteriology. 188:7992-7996. 2006
- Non-ribosomal factors in ribosome subunit assembly are emerging targets for new antibacterial drugs. Current Opinion in Pharmacology. 6:453-458. 2006
- Artificial sperm and epigenetic reprogramming. Nature Biotechnology. 24:1097-1098. 2006
- The worm turns for antimicrobial discovery. Nature Biotechnology. 24:1098-1100. 2006
- Small-Molecule Screening Made Simple for a Difficult Target with a Signaling Nucleic Acid Aptamer that Reports on Deaminase Activity. Angewandte Chemie Angewandte Chemie - International Edition. 45:5648-5652. 2006
- The yjeQ Gene Is Required for Virulence of Staphylococcus aureus. Infection and Immunity. 74:4918-4921. 2006
- Lesions in Teichoic Acid Biosynthesis in Staphylococcus aureus Lead to a Lethal Gain of Function in the Otherwise Dispensable Pathway. Journal of Bacteriology. 188:4183-4189. 2006
- Cell wall assembly in Bacillus subtilis: how spirals and spaces challenge paradigms. Molecular Microbiology Microbiological Sciences. 60:1077-1090. 2006
- Antibiotic stops ‘ping-pong’ match. Nature Nature: New biology. 441:293-294. 2006
- Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: Examination of structural basis for kinetic mechanism. Biochimica et Biophysica Acta - Proteins and Proteomics Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1764:63-69. 2006
- Conserved P-loop GTPases of unknown function in bacteria: an emerging and vital ensemble in bacterial physiology. Biochemistry and Cell Biology. 83:738-746. 2005
- The TagB Protein in Bacillus subtilis 168 Is an Intracellular Peripheral Membrane Protein That Can Incorporate Glycerol Phosphate onto a Membrane-bound Acceptor in Vitro. Journal of Biological Chemistry. 280:36691-36700. 2005
- Two Conserved Histidine Residues Are Critical to the Function of the TagF-like Family of Enzymes. Journal of Biological Chemistry. 280:36683-36690. 2005
- Experimental Screening of Dihydrofolate Reductase Yields a “Test Set” of 50,000 Small Molecules for a Computational Data-Mining and Docking Competition. Journal of Biomolecular Screening. 10:653-657. 2005
- Characterization of the Bacillus subtilis GTPase YloQ and its role in ribosome function. Biochemical Journal. 389:843-852. 2005
- Problems with Co-Funding in Canada. Science The Scientific monthly. 308:1867-1867. 2005
- New Targets and Screening Approaches in Antimicrobial Drug Discovery. Chemical Reviews. 105:759-774. 2005
- Probing the active site of YjeE: a vital Escherichia coli protein of unknown function. Biochemical Journal. 384:577-584. 2004
- Teichoic Acid Is an Essential Polymer in Bacillus subtilis That Is Functionally Distinct from Teichuronic Acid. Journal of Bacteriology. 186:7865-7873. 2004
- High-Throughput Screening Identifies Inhibitors of the SARS Coronavirus Main Proteinase. Chemistry and Biology. 11:1445-1453. 2004
- High-Throughput Screening at McMaster University: Automation in Academe. JALA - Journal of the Association for Laboratory Automation. 9:307-311. 2004
- Multicopy Suppressors for Novel Antibacterial Compounds Reveal Targets and Drug Efflux Susceptibility. Chemistry and Biology. 11:1423-1430. 2004
- An Expedient and Facile One-Step Synthesis of a Biguanide Library by Microwave Irradiation Coupled with Simple Product Filtration. Inhibitors of Dihydrofolate Reductase. Journal of Combinatorial Chemistry. 6:776-782. 2004
- An expedient and facile one-step synthesis of a biguanide library by microwave irradiation coupled with simple product filtration. Inhibitors of dihydrofolate reductase. Journal of Combinatorial Chemistry. 6:776-782. 2004
- Bifunctional Catalysis by CDP-ribitol Synthase: Convergent Recruitment of Reductase and Cytidylyltransferase Activities in Haemophilus influenzae and Staphylococcus aureus. Biochemistry. 43:11802-11812. 2004
- Drugs against superbugs: private lessons from bacteriophages. Trends in Biotechnology. 22:434-436. 2004
- Drugs against superbugs: private lessons from bacteriophages. Trends in Biotechnology. 22:434-436. 2004
- Studies of the Interaction of Escherichia coli YjeQ with the Ribosome In Vitro. Journal of Bacteriology. 186:1381-1387. 2004
- High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate. Bioorganic and Medicinal Chemistry Letters. 13:2493-2496. 2003
- Invited Perspective: Screening in Academe: A Perspective on Implementation of University-Based Small Molecule Screening. Journal of Biomolecular Screening. 8:377-379. 2003
- Purified, Recombinant TagF Protein from Bacillus subtilis 168 Catalyzes the Polymerization of Glycerol Phosphate onto a Membrane Acceptor in Vitro. Journal of Biological Chemistry. 278:18002-18007. 2003
- CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi–Bi reaction mechanism with micromolar Km values. Biochimica et Biophysica Acta - Proteins and Proteomics Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1646:196-206. 2003
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Characterization of the Depletion of 2-
C
-Methyl-
d -Erythritol-2,4-Cyclodiphosphate Synthase in Escherichia coli and Bacillus subtilis. Journal of Bacteriology. 184:5609-5618. 2002 - YjeQ, an Essential, Conserved, Uncharacterized Protein from Escherichia coli, Is an Unusual GTPase with Circularly Permuted G-Motifs and Marked Burst Kinetics. Biochemistry. 41:11109-11117. 2002
- Precise Deletion of tagD and Controlled Depletion of Its Product, Glycerol 3-Phosphate Cytidylyltransferase, Leads to Irregular Morphology and Lysis of Bacillus subtilis Grown at Physiological Temperature. Journal of Bacteriology. 183:6688-6693. 2001
- Development and characterization of a xylose-dependent system for expression of cloned genes in Bacillus subtilis: Conditional complementation of a teichoic acid mutant (vol 67, pg 403, 2001). Applied and Environmental Microbiology. 67:5349-5349. 2001
- Crystallization and preliminary X-ray diffraction studies of glycerol 3-phosphate cytidylyltransferase fromStaphylococcus aureus. Acta Crystallographica Section D: Biological Crystallography. 57:918-920. 2001
- Reduction Precedes Cytidylyl Transfer without Substrate Channeling in Distinct Active Sites of the Bifunctional CDP-Ribitol Synthase from Haemophilus influenzae. Biochemistry. 40:5041-5048. 2001
- Development and Characterization of a Xylose-Dependent System for Expression of Cloned Genes in Bacillus subtilis : Conditional Complementation of a Teichoic Acid Mutant. Applied and Environmental Microbiology. 67:403-410. 2001
- Helicobacter pylori Physiology Predicted from Genomic Comparison of Two Strains. Microbiology and Molecular Biology Reviews. 63:675-707. 1999
- Erratum: Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature Nature: New biology. 397:719-719. 1999
- Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature Nature: New biology. 397:176-180. 1999
- Acetyltransfer Precedes Uridylyltransfer in the Formation of UDP-N-acetylglucosamine in Separable Active Sites of the Bifunctional GlmU Protein of Escherichia coli. Biochemistry. 35:579-585. 1996
- MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli. Journal of Bacteriology. 177:4194-4197. 1995
- Detection and Characterization of a Phospholactoyl-Enzyme Adduct in the Reaction Catalyzed by UDP-N-acetylglucosamine Enolpyruvoyl Transferase, MurZ. Biochemistry. 33:10638-10645. 1994
- Kinetics, Stoichiometry, and Identification of the Reactive Thiolate in the Inactivation of UDP-GlcNAc Enolpyruvoyl Transferase by the Antibiotic Fosfomycin. Biochemistry. 33:10646-10651. 1994
- Expression of recombinant human casein kinase II and recombinant heat shock protein 90 in Escherichia coli and characterization of their interactions.. Proceedings of the National Academy of Sciences of the United States of America. 91:2767-2771. 1994
- Isolation and structural elucidation of a tetrahedral intermediate in the UDP-N-acetylglucosamine enolpyruvoyl transferase enzymic pathway. Journal of the American Chemical Society. 115:10398-10399. 1993
- Enzymatic interesterification of triolein with tripalmitin in canola lecithin-hexane reverse micelles. JAOCS, Journal of the American Oil Chemists' Society. 70:737-744. 1993
- Conformational change and membrane association of the PutA protein are coincident with reduction of its FAD cofactor by proline.. Journal of Biological Chemistry. 268:8972-8979. 1993
- The dependence of the lipolytic activity of Rhizopus arrhizus lipase on surfactant concentration in Aerosol-OT/isooctane reverse micelles and its relationship to enzyme structure. Biochimica et Biophysica Acta - Proteins and Proteomics Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1161:66-72. 1993
- Redesigned purification yields a fully functional PutA protein dimer from Escherichia coli.. Journal of Biological Chemistry. 267:13086-13092. 1992
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chapter
- Biosynthesis of cell wall teichoic acid polymers. 337-350. 2010
- Biosynthesis of cell wall teichoic acid polymers. 337-350. 2009
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conference paper
- S167. Increased N-Acetylaspartate and Myo-Inositol Levels in Clozapine-Responders and Clozapine-Resistant Patients With Schizophrenia. Biological Psychiatry. S361-S362. 2019
- S185. Treatment Response Trajectories in Treatment-Resistant Schizophrenia: A Chart Review Study. Biological Psychiatry. S368-S369. 2019
- S43. Structural Brain Differences Between Cognitively Impaired Patients With and Without Apathy. Biological Psychiatry. S313-S313. 2019
- S46. A Systematic Review of Case-Control Human Studies of Lead (Pb) in Alzheimer's Dementia. Biological Psychiatry. S314-S314. 2019
- F230. Glutamatergic Neurometabolite Levels in Patients With Treatment-Resistant Schizophrenia: A Cross-Sectional 3T Proton MRS Study. Biological Psychiatry. S328-S328. 2018
- S16. GLUTAMATERGIC NEUROMETABOLITE LEVELS IN PATIENTS WITH TREATMENT-RESISTANT SCHIZOPHRENIA: A CROSS-SECTIONAL 3T PROTON MRS STUDY. Schizophrenia Bulletin. S329-S329. 2018
- Targeting bacterial nutrient biosynthesis with natural products. ACS National Meeting Book of Abstracts. 2017
- Genome-Wide Screen for Escherichia coli [NiFe]-Hydrogenase Maturation Factors. FASEB Journal. 2017
- To kill a bacterium, you need to think like a bacterium. FASEB Journal. 2017
- High-Throughput Drug Screening Identifies Pyrimethamine As a Potent and Selective Inhibitor of Acute Myeloid Leukemia. Blood. 2304-2304. 2014
- PIB-Positive PET in Individuals with Early- but Not Late-Onset Frontotemporal Dementia. American Journal of Geriatric Psychiatry. S81-S82. 2014
- HIGH-THROUGHPUT SCREENING FOR GROWTH INHIBITORS OF BURKHOLDERIA CENOCEPACIA. Pediatric Pulmonology. 331-331. 2013
- Chemical genomics in bacteria: A path of ceased resistance. ACS National Meeting Book of Abstracts. 2013
- Cryoprotection from bacterial teichoic acid. Proceedings of SPIE - The International Society for Optical Engineering. 74410m-74410m-7. 2009
- Magnetic resonance tells microbiology where to go; bacterial teichoic acid protects liquid water at sub-zero temperatures. Proceedings of SPIE - The International Society for Optical Engineering. 2008
- Characterization of the putative cell wall stress signaling protein YwaCs and its applications in small molecule screening. Biochemistry and Cell Biology. 198-198. 2008
- Identification of an antibacterial small molecule with novel mode of action using forward chemical genetics. Biochemistry and Cell Biology. 194-194. 2008
- Interaction of the Escherichia coli GTPase EngA with the ribosome. Biochemistry and Cell Biology. 211-212. 2008
- Investigating the requirement for teichoic acid polymers in gram-positive bacteria. Biochemistry and Cell Biology. 192-192. 2008
- Profiling of the transcriptional response of Escherichia coli yjeE to antibiotics suggests a role for this unknown ATPase in stress response. Biochemistry and Cell Biology. 185-185. 2008
- Small and lethal: searching for new antibacterial compounds with novel modes of action. Biochemistry and Cell Biology. 111-115. 2008
- The Canadian chemical biology network: a national resource for Canadian academics. Biochemistry and Cell Biology. 205-205. 2008
- Using flow cytometry to select for artificial riboswitches. Biochemistry and Cell Biology. 202-202. 2008
- Effects of novel beta-glucocerebrosidase enhancers and pharmacological chaperones on protein stability/dynamics probed by hydrogen-deuterium exchange mass spectrometry. Molecular Genetics and Metabolism. S40-S40. 2008
- Development of a Cell-Based Assay for Identification of Viral Entry Inhibitors Against SARS-CoV by High Throughput Screening (HTS). Antiviral Research. A82-A82. 2007
- Teichoic acid biosynthesis: Expression and substrate synthesis of S. aureus TagA glycosyltransferase. ACS National Meeting Book of Abstracts. U639-U639. 2005
- IDENTIFYING NOVEL PHARMACOLOGICAL CHAPERONES FOR LYSOSOMAL DISEASES USING A HIGH THROUGHPUT APPROACH. Journal of Inherited Metabolic Disease. 153-153. 2005
- Impact of YjeQ, an essential sub-stoichiometric ribosome-associated GTPase from Escherchia coli, on translation in vitro. FASEB Journal. C17-C18. 2004