Physicochemical and Structural Parameters Contributing to the Antibacterial Activity and Efflux Susceptibility of Small-Molecule Inhibitors of Escherichia coli Journal Articles uri icon

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abstract

  • Discovering new Gram-negative antibiotics has been a challenge for decades. This has been largely attributed to a limited understanding of the molecular descriptors governing Gram-negative permeation and efflux evasion.

authors

  • El Zahed, Sara S
  • French, Shawn
  • Farha, Maya A
  • Kumar, Garima
  • Brown, Eric

publication date

  • March 18, 2021