Chemical Inhibition of Bacterial Ribosome Biogenesis Shows Efficacy in a Worm Infection Model Academic Article uri icon

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abstract

  • ABSTRACTThe development of antibacterial compounds that perturb novel processes is an imperative in the challenge presented by widespread antibiotic resistance. While many antibiotics target the ribosome, molecules that inhibit ribosome assembly have yet to be used in this manner. Here we show that a novel inhibitor of ribosome biogenesis, lamotrigine, is capable of rescuingCaenorhabditis elegansfrom an establishedSalmonellainfection, revealing that ribosome biogenesis is a promising target for the development of new antibiotics.

authors

  • Stokes, Jonathan M
  • Selin, Carrie
  • Cardona, Silvia T
  • Brown, Eric

publication date

  • May 2015