Journal article
Bifunctional Catalysis by CDP-ribitol Synthase: Convergent Recruitment of Reductase and Cytidylyltransferase Activities in Haemophilus influenzae and Staphylococcus aureus †
Abstract
CDP-ribitol synthase catalyzes the formation of CDP-ribitol from ribulose 5-phosphate, NADPH, and CTP. CDP-ribitol is an activated precursor for the synthesis of virulence-associated polysaccharides in the capsule of the Gram-negative pathogen Haemophilus influenzae and in the cell walls of Gram-positive pathogens including Staphylococcus aureus. We showed previously that CDP-ribitol synthase activity in H. influenzae is catalyzed by the …
Authors
Pereira MP; Brown ED
Journal
Biochemistry, Vol. 43, No. 37, pp. 11802–11812
Publisher
American Chemical Society (ACS)
Publication Date
September 1, 2004
DOI
10.1021/bi048866v
ISSN
0006-2960