Conference
High-Throughput Drug Screening Identifies Pyrimethamine As a Potent and Selective Inhibitor of Acute Myeloid Leukemia
Abstract
Abstract
Introduction: Hematopoietic stem/progenitor cell differentiation is blocked in acute myeloid leukemia (AML) resulting in cytopenias and high risk of death. Most patients with AML become resistant to treatment due to lack of effective cytotoxic and differentiation fostering compounds. High expression of MN1 confers poor prognosis to AML patients and induces resistance to cytarabine and all-trans-retinoic acid (ATRA) …
Authors
Sharma A; Jyotsana N; Lai CK; Chaturvedi A; Görlich K; Murphy C; Blanchard JE; Ganser A; Brown E; Hassell JA
Volume
124
Publisher
American Society of Hematology
Publication Date
December 6, 2014
DOI
10.1182/blood.v124.21.2304.2304
Conference proceedings
Blood
Issue
21
ISSN
0006-4971