Journal article
A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers.
Abstract
Oncolytic viruses (OVs) are promising anticancer agents but like other cancer monotherapies, the genetic heterogeneity of human malignancies can lead to treatment resistance. We used a virus/cell-based assay to screen diverse chemical libraries to identify small molecules that could act in synergy with OVs to destroy tumor cells that resist viral infection. Several molecules were identified that aid in viral oncolysis, enhancing virus …
Authors
Diallo J-S; Le Boeuf F; Lai F; Cox J; Vaha-Koskela M; Abdelbary H; MacTavish H; Waite K; Falls T; Wang J
Journal
Mol Ther, Vol. 18, No. 6, pp. 1123–1129
Publication Date
6 2010
DOI
10.1038/mt.2010.67