Journal article
Quantitative Genome-Wide Genetic Interaction Screens Reveal Global Epistatic Relationships of Protein Complexes in Escherichia coli
Abstract
Large-scale proteomic analyses in Escherichia coli have documented the composition and physical relationships of multiprotein complexes, but not their functional organization into biological pathways and processes. Conversely, genetic interaction (GI) screens can provide insights into the biological role(s) of individual gene and higher order associations. Combining the information from both approaches should elucidate how complexes and …
Authors
Babu M; Arnold R; Bundalovic-Torma C; Gagarinova A; Wong KS; Kumar A; Stewart G; Samanfar B; Aoki H; Wagih O
Journal
PLOS Genetics, Vol. 10, No. 2,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pgen.1004120
ISSN
1553-7390