Creative targeting of the Gram‐negative outer membrane in antibiotic discovery Journal Articles

abstract

• AbstractThe rising threat of multidrug‐resistant Gram‐negative bacteria is exacerbated by the scarcity of new antibiotics in the development pipeline. Permeability through the outer membrane remains one of the leading hurdles in discovery efforts. However, the essentiality of a robust outer membrane makes itself an intriguing antimicrobial target. Herein, we review drug discovery efforts targeting the outer membrane and the prospective antimicrobial leads identified.

authors

• MacNair, Craig R
• Tsai, Caressa N
• Brown, Eric

status

• published 

publication date

• January 2020

has subject area

• Animals (MeSH)
• Anti-Bacterial Agents (MeSH)
• Drug Delivery Systems (MeSH)
• Drug Discovery (MeSH)
• Drug Resistance, Multiple, Bacterial (MeSH)
• General Science & Technology (Science Metrix)
• Gram-Negative Bacteria (MeSH)
• Humans (MeSH)

published in

• Annals of the New York Academy of Sciences  Journal

keywords

• Animals
• Anti-Bacterial Agents
• Drug Delivery Systems
• Drug Discovery
• Drug Resistance, Multiple, Bacterial
• Gram-Negative Bacteria
• Gram-negative bacteria
• Humans
• antibiotic discovery
• outer membrane

Digital Object Identifier (DOI)

• 10.1111/nyas.14280

PubMed ID

• 31762048

start page

• 69

end page

• 85

volume

• 1459

issue

• 1