Journal article
Assembly and clustering of natural antibiotics guides target identification
Abstract
A retrobiosynthetic algorithm that relates known antibiotics by the similarities of their biosynthetic pathways to cluster them into distinct classes. Focusing on the telomycins helps to define the mechanism of action of this antibiotic class.
Authors
Johnston CW; Skinnider MA; Dejong CA; Rees PN; Chen GM; Walker CG; French S; Brown ED; Bérdy J; Liu DY
Journal
Nature Chemical Biology, Vol. 12, No. 4, pp. 233–239
Publisher
Springer Nature
Publication Date
April 2016
DOI
10.1038/nchembio.2018
ISSN
1552-4450